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Murcko scaffold

Ring system with 3 rings and 21 atoms

48 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
48
With full pages
9
Scaffold SMILES

O=C(CN1C(=O)COc2ccccc21)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CN1C(=O)COc2ccccc21)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 48 chemicals

2-(2-Ethyl-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl)-N-(2-methoxy-phenyl)-acetamide chemical structure, C19H20N2O4, CAS 606119-24-8
2-(2-Ethyl-3-oxo-2,3-dihydro-benzo[1,4]oxazin-4-yl)-N-(2-methoxy-phenyl)-acetamide
CAS 606119-24-8C19H20N2O4
2-(6-Chloro-3-oxo-1,4-benzoxazin-4-yl)-N-(4-methoxyphenyl)acetamide chemical structure, C17H15ClN2O4, CAS 727680-47-9
2-(6-Chloro-3-oxo-1,4-benzoxazin-4-yl)-N-(4-methoxyphenyl)acetamide
CAS 727680-47-9C17H15ClN2O4
2-(6-Chloro-3-oxo-1,4-benzoxazin-4-yl)-N-(3-methylphenyl)acetamide chemical structure, C17H15ClN2O3, CAS 824974-01-8
2-(6-Chloro-3-oxo-1,4-benzoxazin-4-yl)-N-(3-methylphenyl)acetamide
CAS 824974-01-8C17H15ClN2O3
2-(6-Chloro-3-oxo-1,4-benzoxazin-4-yl)-N-(2,3-dimethylphenyl)acetamide chemical structure, C18H17ClN2O3, CAS 5185-49-9
2-(6-Chloro-3-oxo-1,4-benzoxazin-4-yl)-N-(2,3-dimethylphenyl)acetamide
CAS 5185-49-9C18H17ClN2O3
N-(3,4-Dimethoxyphenyl)-2-(3-oxo-1,4-benzoxazin-4-yl)acetamide chemical structure, C18H18N2O5, CAS 606118-40-5
N-(3,4-Dimethoxyphenyl)-2-(3-oxo-1,4-benzoxazin-4-yl)acetamide
CAS 606118-40-5C18H18N2O5
4H-1,4-Benzoxazine-4-acetamide,2,3-dihydro-N-(4-methoxyphenyl)-6-methyl-3-oxo-(9CI) chemical structure, C18H18N2O4, CAS 606119-53-3
4H-1,4-Benzoxazine-4-acetamide,2,3-dihydro-N-(4-methoxyphenyl)-6-methyl-3-oxo-(9CI)
CAS 606119-53-3C18H18N2O4
4H-1,4-Benzoxazine-4-acetamide,2,3-dihydro-N-(3-methoxyphenyl)-6-methyl-3-oxo-(9CI) chemical structure, C18H18N2O4, CAS 606119-54-4
4H-1,4-Benzoxazine-4-acetamide,2,3-dihydro-N-(3-methoxyphenyl)-6-methyl-3-oxo-(9CI)
CAS 606119-54-4C18H18N2O4
4H-1,4-Benzoxazine-4-acetamide,2,3-dihydro-N-(2-methoxy-5-methylphenyl)-6-methyl-3-oxo-(9CI) chemical structure, C19H20N2O4, CAS 606119-56-6
4H-1,4-Benzoxazine-4-acetamide,2,3-dihydro-N-(2-methoxy-5-methylphenyl)-6-methyl-3-oxo-(9CI)
CAS 606119-56-6C19H20N2O4
4H-1,4-Benzoxazine-4-acetamide,2,3-dihydro-6-methyl-3-oxo-N-[2-(trifluoromethyl)phenyl]-(9CI) chemical structure, C18H15F3N2O3, CAS 606119-66-8
4H-1,4-Benzoxazine-4-acetamide,2,3-dihydro-6-methyl-3-oxo-N-[2-(trifluoromethyl)phenyl]-(9CI)
CAS 606119-66-8C18H15F3N2O3
2-(6-Chloro-3-oxo-1,4-benzoxazin-4-yl)-N-(2-fluorophenyl)acetamide chemical structure, C16H12ClFN2O3, CAS 838592-00-0
2-(6-Chloro-3-oxo-1,4-benzoxazin-4-yl)-N-(2-fluorophenyl)acetamide
CAS 838592-00-0C16H12ClFN2O3
2-(6-Chloro-3-oxo-1,4-benzoxazin-4-yl)-N-(2-nitrophenyl)acetamide chemical structure, C16H12ClN3O5, CAS 831211-65-5
2-(6-Chloro-3-oxo-1,4-benzoxazin-4-yl)-N-(2-nitrophenyl)acetamide
CAS 831211-65-5C16H12ClN3O5
Methyl 2-[[2-(3-oxo-1,4-benzoxazin-4-yl)acetyl]amino]benzoate chemical structure, C18H16N2O5, CAS 839686-89-4
Methyl 2-[[2-(3-oxo-1,4-benzoxazin-4-yl)acetyl]amino]benzoate
CAS 839686-89-4C18H16N2O5
2-(6-Chloro-3-oxo-1,4-benzoxazin-4-yl)-N-[2-(difluoromethoxy)phenyl]acetamide chemical structure, C17H13ClF2N2O4, CAS 839688-36-7
2-(6-Chloro-3-oxo-1,4-benzoxazin-4-yl)-N-[2-(difluoromethoxy)phenyl]acetamide
CAS 839688-36-7C17H13ClF2N2O4
N-(2-Chlorophenyl)-2-(3-oxo-1,4-benzoxazin-4-yl)acetamide chemical structure, C16H13ClN2O3, CAS 42968-27-4
N-(2-Chlorophenyl)-2-(3-oxo-1,4-benzoxazin-4-yl)acetamide
CAS 42968-27-4C16H13ClN2O3
N-(2,4-Dichlorophenyl)-2-(3-oxo-1,4-benzoxazin-4-yl)acetamide chemical structure, C16H12Cl2N2O3, CAS 839689-83-7
N-(2,4-Dichlorophenyl)-2-(3-oxo-1,4-benzoxazin-4-yl)acetamide
CAS 839689-83-7C16H12Cl2N2O3
N-(3-Methoxyphenyl)-2-(3-oxo-1,4-benzoxazin-4-yl)acetamide chemical structure, C17H16N2O4, CAS 42968-23-0
N-(3-Methoxyphenyl)-2-(3-oxo-1,4-benzoxazin-4-yl)acetamide
CAS 42968-23-0C17H16N2O4
Methyl 2-chloro-5-[[2-(3-oxo-1,4-benzoxazin-4-yl)acetyl]amino]benzoate chemical structure, C18H15ClN2O5, CAS 839693-50-4
Methyl 2-chloro-5-[[2-(3-oxo-1,4-benzoxazin-4-yl)acetyl]amino]benzoate
CAS 839693-50-4C18H15ClN2O5
3-[[2-(3-Oxo-1,4-benzoxazin-4-yl)acetyl]amino]benzoic acid chemical structure, C17H14N2O5, CAS 839694-63-2
3-[[2-(3-Oxo-1,4-benzoxazin-4-yl)acetyl]amino]benzoic acid
CAS 839694-63-2C17H14N2O5
3-[[2-(6-Chloro-3-oxo-1,4-benzoxazin-4-yl)acetyl]amino]benzoic acid chemical structure, C17H13ClN2O5, CAS 839695-64-6
3-[[2-(6-Chloro-3-oxo-1,4-benzoxazin-4-yl)acetyl]amino]benzoic acid
CAS 839695-64-6C17H13ClN2O5
N-(4-Acetylphenyl)-2-(3-oxo-1,4-benzoxazin-4-yl)acetamide chemical structure, C18H16N2O4, CAS 839695-81-7
N-(4-Acetylphenyl)-2-(3-oxo-1,4-benzoxazin-4-yl)acetamide
CAS 839695-81-7C18H16N2O4
Ethyl 4-[[2-(3-oxo-1,4-benzoxazin-4-yl)acetyl]amino]benzoate chemical structure, C19H18N2O5, CAS 839696-49-0
Ethyl 4-[[2-(3-oxo-1,4-benzoxazin-4-yl)acetyl]amino]benzoate
CAS 839696-49-0C19H18N2O5
N-(2,4-Difluorophenyl)-2-(3-oxo-1,4-benzoxazin-4-yl)acetamide chemical structure, C16H12F2N2O3, CAS 880410-39-9
N-(2,4-Difluorophenyl)-2-(3-oxo-1,4-benzoxazin-4-yl)acetamide
CAS 880410-39-9C16H12F2N2O3
N-(2,3-Dimethylphenyl)-2-(3-oxo-1,4-benzoxazin-4-yl)acetamide chemical structure, C18H18N2O3, CAS 842116-35-2
N-(2,3-Dimethylphenyl)-2-(3-oxo-1,4-benzoxazin-4-yl)acetamide
CAS 842116-35-2C18H18N2O3
N-(3-Chloro-4-fluorophenyl)-2-(3-oxo-1,4-benzoxazin-4-yl)acetamide chemical structure, C16H12ClFN2O3, CAS 606118-32-5
N-(3-Chloro-4-fluorophenyl)-2-(3-oxo-1,4-benzoxazin-4-yl)acetamide
CAS 606118-32-5C16H12ClFN2O3