Murcko scaffold
Ring system with 3 rings and 20 atoms
79 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 20
- Chemicals
- 79
- With full pages
- 14
Scaffold SMILES
O=C(Cc1cccc2ccccc12)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 79 chemicals
![N-[3-(Dimethylamino)phenyl]-2-naphthalen-1-ylacetamide chemical structure, C20H20N2O, CAS 6049-90-7](/s/XHRZJKOZALFQKM-UHFFFAOYSA-N.svg)
N-[3-(Dimethylamino)phenyl]-2-naphthalen-1-ylacetamide
CAS 6049-90-7C20H20N2O
N-(2,5-Dimethoxyphenyl)-2-naphthalen-1-ylacetamide
CAS 352347-33-2C20H19NO3
N-(3-Methoxyphenyl)-2-naphthalen-1-ylacetamide
CAS 299418-26-1C19H17NO2
![5-{[N-(4-Fluorophenyl)carbamoyl]methyl}naphthalenesulfinic acid chemical structure, C18H14FNO3S, CAS 308292-56-0](/s/HSBHXBUFUADIFN-UHFFFAOYSA-N.svg)
5-{[N-(4-Fluorophenyl)carbamoyl]methyl}naphthalenesulfinic acid
CAS 308292-56-0C18H14FNO3S
N-(4-Acetamidophenyl)-2-(naphthalen-1-yl)acetamide
CAS 531493-53-5C20H18N2O2
Ethyl 4-(2-naphthylacetylamino)benzoate
CAS 111200-09-0C21H19NO3
1-Naphthaleneacetamide, N-(4-methylphenyl)-
CAS 154192-54-8C19H17NO
2-Naphthyl-N-(4-sulfamoylphenyl)acetamide
CAS 5939-84-4C18H16N2O3S
N-(2-Methoxyphenyl)-2-naphthalen-1-ylacetamide
CAS 339047-17-5C19H17NO2
N-(2,4-Dimethoxyphenyl)-1-naphthaleneacetamide
CAS 499997-39-6C20H19NO3
![2-[(1-Naphthylacetyl)amino]benzoic acid chemical structure, C19H15NO3, CAS 101895-37-8](/s/DTDMYFUZEMKFOK-UHFFFAOYSA-N.svg)
2-[(1-Naphthylacetyl)amino]benzoic acid
CAS 101895-37-8C19H15NO3
N-(2,5-Dichlorophenyl)-2-naphthalen-1-ylacetamide
CAS 331436-31-8C18H13Cl2NO
N-(2-Methoxy-5-methylphenyl)-2-naphthalen-1-ylacetamide
CAS 415695-98-6C20H19NO2
4-(2-Naphthylacetylamino)benzoic acid
CAS 101895-38-9C19H15NO3
N-{5-Nitro-2-methylphenyl}-2-(1-naphthyl)acetamide
CAS 448231-83-2C19H16N2O3
![N-{4-[Acetyl(methyl)amino]phenyl}-2-(1-naphthyl)acetamide chemical structure, C21H20N2O2, CAS 581781-99-9](/s/JQRWKYQNXHWDBW-UHFFFAOYSA-N.svg)
N-{4-[Acetyl(methyl)amino]phenyl}-2-(1-naphthyl)acetamide
CAS 581781-99-9C21H20N2O2
N-(2,4-Dichlorophenyl)-2-naphthalen-1-ylacetamide
CAS 658069-54-6C18H13Cl2NO
N-(5-Chloro-2-methylphenyl)-2-naphthalen-1-ylacetamide
CAS 415692-80-7C19H16ClNO
N-(4-Fluorophenyl)-2-(1-naphthyl)acetamide
CAS 642939-86-4C18H14FNO
N-(4-Methoxyphenyl)-2-(1-naphthyl)acetamide
CAS 423738-74-3C19H17NO2
![Ethyl 3-[(naphthalen-1-ylacetyl)amino]benzoate chemical structure, C21H19NO3, CAS 723757-02-6](/s/DZZGWWCJXWJFAY-UHFFFAOYSA-N.svg)
Ethyl 3-[(naphthalen-1-ylacetyl)amino]benzoate
CAS 723757-02-6C21H19NO3
N-(3-Methylsulfanylphenyl)-2-naphthalen-1-ylacetamide
CAS 694507-26-1C19H17NOS
N-(3-Chloro-4-methylphenyl)-2-(1-naphthyl)acetamide
CAS 561003-20-1C19H16ClNO
N-(2-Ethoxyphenyl)-2-naphthalen-1-ylacetamide
CAS 723758-00-7C20H19NO2
- N-(5-Chloro-2-hydroxyphenyl)-2-(1-naphthyl)acetamide723262-46-2C18H14ClNO2
- Methyl 4-[(naphthalen-1-ylacetyl)amino]benzoate423736-07-6C20H17NO3
- N-(4-Ethoxyphenyl)-2-(1-naphthyl)acetamide353775-83-4C20H19NO2
- 2-[(1-Naphthylacetyl)amino]benzamide447427-82-9C19H16N2O2
- N-(4-Acetylphenyl)-2-naphthalen-1-ylacetamide339047-18-6C20H17NO2
- N-(2,6-Dichlorophenyl)-2-naphthalen-1-ylacetamide445264-80-2C18H13Cl2NO
- N-(2-Methoxy-5-nitrophenyl)-2-(naphthalen-1-yl)acetamide391228-79-8C19H16N2O4
- N-(2-Hydroxy-4-methylphenyl)-2-(1-naphthyl)acetamide694485-29-5C19H17NO2
- 5-(2-(4-Ethoxyanilino)-2-oxoethyl)-1-naphthalenesulfinic acid308292-57-1C20H19NO4S
- 5-{[N-(4-Iodophenyl)carbamoyl]methyl}naphthalenesulfinic acid308292-53-7C18H14INO3S
- N-(4-Bromo-3-chlorophenyl)-2-(1-naphthyl)acetamide581782-00-5C18H13BrClNO
- N-{4-[(Diethylamino)sulfonyl]phenyl}-2-(1-naphthyl)acetamide642940-41-8C22H24N2O3S
- 2-(6-Bromo-2-methoxy-1-naphthyl)-N-(2,5-dimethoxyphenyl)acetamide622816-56-2C21H20BrNO4
- 2-(6-Bromo-2-methoxynaphthalen-1-yl)-N-(2,4-dimethoxyphenyl)acetamide622816-62-0C21H20BrNO4
- 2-(6-Bromo-2-methoxynaphthalen-1-yl)-N-methyl-N-phenylacetamide622817-28-1C20H18BrNO2
- 2-(6-Bromo-2-methoxynaphthalen-1-yl)-N-(2-fluorophenyl)acetamide622817-46-3C19H15BrFNO2
- 2-(6-Bromo-2-methoxy-1-naphthyl)-N-(2-methylphenyl)acetamide622818-50-2C20H18BrNO2
- 2-(6-Bromo-2-methoxynaphthalen-1-yl)-N-(2-methoxyphenyl)acetamide622818-65-9C20H18BrNO3
- 2-Naphthalen-1-yl-N-(2,4,5-trichlorophenyl)acetamide531493-55-7C18H12Cl3NO
- N-[4-(Acetylsulfamoyl)phenyl]-2-naphthalen-1-ylacetamide496011-16-6C20H18N2O4S
- N-{4-[(Diallylamino)sulfonyl]phenyl}-2-(1-naphthyl)acetamide713112-54-0C24H24N2O3S
- N-(2,3-Dimethylphenyl)-2-naphthalen-1-ylacetamide415694-45-0C20H19NO
- N-(2-Ethylphenyl)-2-naphthalen-1-ylacetamide694497-64-8C20H19NO
- N-(3,4-Dimethoxyphenyl)-2-naphthalen-1-ylacetamide585523-36-0C20H19NO3
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Nc1ccccc1)Oc1cccc2cccnc1242 chemicals
O=C(Nc1ccccc1)Nc1cccc2ccccc1221 chemicals
O=C(COc1ccccc1)N1CCOc2ccccc2117 chemicals![Scaffold O=C(Cc1n[nH]c(=O)c2ccccc12)Nc1ccccc1](/scaffold/RCKILYGUNWZTBY-UHFFFAOYSA-N/structure.svg)
O=C(Cc1n[nH]c(=O)c2ccccc12)Nc1ccccc112 chemicals
O=C(COc1ccccc1)N1CCCc2ccccc2111 chemicals
c1ccc(CNCc2cccc3ccccc23)cc110 chemicals
O=C(NCc1cccc2ccccc12)c1ccccc110 chemicals
O=C(NCc1ccccc1)c1ccnc2ccccc129 chemicals
O=C(CN1C(=O)COc2ccccc21)Nc1ccccc19 chemicals
O=C1CN(C(=O)COc2ccccc2)c2ccccc2N19 chemicals
O=C(NNc1ncnc2ccccc12)c1ccccc18 chemicals
O=c1cc(CNCc2ccccc2)c2ccccc2o18 chemicals