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Murcko scaffold

Ring system with 3 rings and 21 atoms

50 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
50
With full pages
12
Scaffold SMILES

O=C(Cc1n[nH]c(=O)c2ccccc12)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cc1n[nH]c(=O)c2ccccc12)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 50 chemicals

2-(3-Methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-methylphenyl)acetamide chemical structure, C18H17N3O2, CAS 351066-18-7
2-(3-Methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-(4-methylphenyl)acetamide
CAS 351066-18-7C18H17N3O2
N-(2-Ethyl-6-methylphenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide chemical structure, C20H21N3O2, CAS 442571-97-3
N-(2-Ethyl-6-methylphenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide
CAS 442571-97-3C20H21N3O2
2-[[2-(3-Methyl-4-oxophthalazin-1-yl)acetyl]amino]benzoic acid chemical structure, C18H15N3O4, CAS 433259-13-3
2-[[2-(3-Methyl-4-oxophthalazin-1-yl)acetyl]amino]benzoic acid
CAS 433259-13-3C18H15N3O4
N-(3,4-Dimethylphenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide chemical structure, C19H19N3O2, CAS 591242-11-4
N-(3,4-Dimethylphenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide
CAS 591242-11-4C19H19N3O2
N-(3-Chlorophenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide chemical structure, C17H14ClN3O2, CAS 592466-95-0
N-(3-Chlorophenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide
CAS 592466-95-0C17H14ClN3O2
N-(3-Hydroxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide chemical structure, C17H15N3O3, CAS 412922-94-2
N-(3-Hydroxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
CAS 412922-94-2C17H15N3O3
N-(4-Chlorophenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide chemical structure, C17H14ClN3O2, CAS 421570-14-1
N-(4-Chlorophenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide
CAS 421570-14-1C17H14ClN3O2
N-(2-Methoxyphenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide chemical structure, C18H17N3O3, CAS 429653-39-4
N-(2-Methoxyphenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide
CAS 429653-39-4C18H17N3O3
N-(4-Methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide chemical structure, C18H17N3O3, CAS 431930-94-8
N-(4-Methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
CAS 431930-94-8C18H17N3O3
N-(4-Hydroxyphenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide chemical structure, C17H15N3O3, CAS 510737-43-6
N-(4-Hydroxyphenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide
CAS 510737-43-6C17H15N3O3
N-(4-Bromophenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide chemical structure, C17H14BrN3O2, CAS 510760-36-8
N-(4-Bromophenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide
CAS 510760-36-8C17H14BrN3O2
2-(3-Methyl-4-oxophthalazin-1-yl)-N-[2-(trifluoromethyl)phenyl]acetamide chemical structure, C18H14F3N3O2, CAS 510760-41-5
2-(3-Methyl-4-oxophthalazin-1-yl)-N-[2-(trifluoromethyl)phenyl]acetamide
CAS 510760-41-5C18H14F3N3O2
N-(2,4-Dichlorophenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide chemical structure, C17H13Cl2N3O2, CAS 694455-90-8
N-(2,4-Dichlorophenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide
CAS 694455-90-8C17H13Cl2N3O2
N-(2-Bromophenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide chemical structure, C17H14BrN3O2, CAS 434292-67-8
N-(2-Bromophenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide
CAS 434292-67-8C17H14BrN3O2
2-(3-Methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C18H14F3N3O2, CAS 694446-97-4
2-(3-Methyl-4-oxo-3,4-dihydrophthalazin-1-yl)-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 694446-97-4C18H14F3N3O2
N-(4-Butylphenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide chemical structure, C21H23N3O2, CAS 592466-97-2
N-(4-Butylphenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide
CAS 592466-97-2C21H23N3O2
N-(2,5-Dimethoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide chemical structure, C19H19N3O4, CAS 335390-36-8
N-(2,5-Dimethoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
CAS 335390-36-8C19H19N3O4
N-(5-Chloro-2-methoxyphenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide chemical structure, C18H16ClN3O3, CAS 874587-78-7
N-(5-Chloro-2-methoxyphenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide
CAS 874587-78-7C18H16ClN3O3
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-(3-methyl-4-oxophthalazin-1-yl)acetamide chemical structure, C18H13ClF3N3O2, CAS 874584-82-4
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-(3-methyl-4-oxophthalazin-1-yl)acetamide
CAS 874584-82-4C18H13ClF3N3O2
N-(3-Bromophenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide chemical structure, C17H14BrN3O2, CAS 874584-95-9
N-(3-Bromophenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide
CAS 874584-95-9C17H14BrN3O2
N-(2,3-Dimethylphenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide chemical structure, C19H19N3O2, CAS 874584-97-1
N-(2,3-Dimethylphenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide
CAS 874584-97-1C19H19N3O2
2-(3-Methyl-4-oxophthalazin-1-yl)-N-(4-propan-2-ylphenyl)acetamide chemical structure, C20H21N3O2, CAS 874584-98-2
2-(3-Methyl-4-oxophthalazin-1-yl)-N-(4-propan-2-ylphenyl)acetamide
CAS 874584-98-2C20H21N3O2
N-(5-Chloro-2-methylphenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide chemical structure, C18H16ClN3O2, CAS 874585-00-9
N-(5-Chloro-2-methylphenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide
CAS 874585-00-9C18H16ClN3O2
N-(3,4-Dichlorophenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide chemical structure, C17H13Cl2N3O2, CAS 874585-02-1
N-(3,4-Dichlorophenyl)-2-(3-methyl-4-oxophthalazin-1-yl)acetamide
CAS 874585-02-1C17H13Cl2N3O2