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Murcko scaffold

Ring system with 2 rings and 21 atoms

26 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
21
Chemicals
26
With full pages
3
Scaffold SMILES

O=C(CNc1ccccc1)NCCSCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CNc1ccccc1)NCCSCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

2-(4-Ethoxy-N-methylsulfonylanilino)-N-[2-[(4-methylphenyl)methylsulfanyl]ethyl]acetamide chemical structure, C21H28N2O4S2, CAS 357322-97-5
2-(4-Ethoxy-N-methylsulfonylanilino)-N-[2-[(4-methylphenyl)methylsulfanyl]ethyl]acetamide
CAS 357322-97-5C21H28N2O4S2
N-[2-[(2,4-Dichlorophenyl)methylsulfanyl]ethyl]-2-(2-ethoxy-N-methylsulfonylanilino)acetamide chemical structure, C20H24Cl2N2O4S2, CAS 433235-70-2
N-[2-[(2,4-Dichlorophenyl)methylsulfanyl]ethyl]-2-(2-ethoxy-N-methylsulfonylanilino)acetamide
CAS 433235-70-2C20H24Cl2N2O4S2
N-[2-[(2,4-Dichlorophenyl)methylsulfanyl]ethyl]-2-(N-methylsulfonyl-4-propan-2-ylanilino)acetamide chemical structure, C21H26Cl2N2O3S2, CAS 432496-17-8
N-[2-[(2,4-Dichlorophenyl)methylsulfanyl]ethyl]-2-(N-methylsulfonyl-4-propan-2-ylanilino)acetamide
CAS 432496-17-8C21H26Cl2N2O3S2
N-[2-[(2-Chlorophenyl)methylsulfanyl]ethyl]-2-(4-methyl-N-methylsulfonylanilino)acetamide chemical structure, C19H23ClN2O3S2, CAS 431883-32-8
N-[2-[(2-Chlorophenyl)methylsulfanyl]ethyl]-2-(4-methyl-N-methylsulfonylanilino)acetamide
CAS 431883-32-8C19H23ClN2O3S2
N-(2-Benzylsulfanylethyl)-2-(3,4-dimethoxy-N-methylsulfonylanilino)acetamide chemical structure, C20H26N2O5S2, CAS 428472-92-8
N-(2-Benzylsulfanylethyl)-2-(3,4-dimethoxy-N-methylsulfonylanilino)acetamide
CAS 428472-92-8C20H26N2O5S2
N-{2-[(3-Chlorobenzyl)sulfanyl]ethyl}-2-[4-fluoro(methylsulfonyl)anilino]acetamide chemical structure, C18H20ClFN2O3S2, CAS 428462-56-0
N-{2-[(3-Chlorobenzyl)sulfanyl]ethyl}-2-[4-fluoro(methylsulfonyl)anilino]acetamide
CAS 428462-56-0C18H20ClFN2O3S2
2-(4-Ethyl-N-methylsulfonylanilino)-N-[2-[(4-methylphenyl)methylsulfanyl]ethyl]acetamide chemical structure, C21H28N2O3S2, CAS 528535-22-0
2-(4-Ethyl-N-methylsulfonylanilino)-N-[2-[(4-methylphenyl)methylsulfanyl]ethyl]acetamide
CAS 528535-22-0C21H28N2O3S2
N-[2-[(2,6-Dichlorophenyl)methylsulfanyl]ethyl]-2-(3-methoxy-N-methylsulfonylanilino)acetamide chemical structure, C19H22Cl2N2O4S2, CAS 535947-17-2
N-[2-[(2,6-Dichlorophenyl)methylsulfanyl]ethyl]-2-(3-methoxy-N-methylsulfonylanilino)acetamide
CAS 535947-17-2C19H22Cl2N2O4S2
N-[2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]ethyl]-2-(3-chloro-2-methyl-N-methylsulfonylanilino)acetamide chemical structure, C19H21Cl2FN2O3S2, CAS 528562-96-1
N-[2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]ethyl]-2-(3-chloro-2-methyl-N-methylsulfonylanilino)acetamide
CAS 528562-96-1C19H21Cl2FN2O3S2
N-[2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]ethyl]-2-(2,5-dimethoxy-N-methylsulfonylanilino)acetamide chemical structure, C20H24ClFN2O5S2, CAS 591744-60-4
N-[2-[(2-Chloro-6-fluorophenyl)methylsulfanyl]ethyl]-2-(2,5-dimethoxy-N-methylsulfonylanilino)acetamide
CAS 591744-60-4C20H24ClFN2O5S2
N-(2-Benzylsulfanylethyl)-2-[N-(dimethylsulfamoyl)anilino]acetamide chemical structure, C19H25N3O3S2, CAS 824980-59-8
N-(2-Benzylsulfanylethyl)-2-[N-(dimethylsulfamoyl)anilino]acetamide
CAS 824980-59-8C19H25N3O3S2
2-(5-Chloro-2-methoxy-N-methylsulfonylanilino)-N-[2-[(4-chlorophenyl)methylsulfanyl]ethyl]acetamide chemical structure, C19H22Cl2N2O4S2, CAS 425683-19-8
2-(5-Chloro-2-methoxy-N-methylsulfonylanilino)-N-[2-[(4-chlorophenyl)methylsulfanyl]ethyl]acetamide
CAS 425683-19-8C19H22Cl2N2O4S2
2-(3-Chloro-N-methylsulfonylanilino)-N-[2-[(3-chlorophenyl)methylsulfanyl]ethyl]acetamide chemical structure, C18H20Cl2N2O3S2, CAS 426217-43-8
2-(3-Chloro-N-methylsulfonylanilino)-N-[2-[(3-chlorophenyl)methylsulfanyl]ethyl]acetamide
CAS 426217-43-8C18H20Cl2N2O3S2
2-(3,4-Dimethyl-N-methylsulfonylanilino)-N-[2-[(4-methylphenyl)methylsulfanyl]ethyl]acetamide chemical structure, C21H28N2O3S2, CAS 426229-24-5
2-(3,4-Dimethyl-N-methylsulfonylanilino)-N-[2-[(4-methylphenyl)methylsulfanyl]ethyl]acetamide
CAS 426229-24-5C21H28N2O3S2
2-(3,5-Dimethyl-N-methylsulfonylanilino)-N-[2-[(3-methylphenyl)methylsulfanyl]ethyl]acetamide chemical structure, C21H28N2O3S2, CAS 432499-12-2
2-(3,5-Dimethyl-N-methylsulfonylanilino)-N-[2-[(3-methylphenyl)methylsulfanyl]ethyl]acetamide
CAS 432499-12-2C21H28N2O3S2
N-[2-[(3,4-Dichlorophenyl)methylsulfanyl]ethyl]-2-(N-methylsulfonyl-4-propan-2-ylanilino)acetamide chemical structure, C21H26Cl2N2O3S2, CAS 432499-60-0
N-[2-[(3,4-Dichlorophenyl)methylsulfanyl]ethyl]-2-(N-methylsulfonyl-4-propan-2-ylanilino)acetamide
CAS 432499-60-0C21H26Cl2N2O3S2
2-(4-Fluoro-N-methylsulfonylanilino)-N-[2-[(3-methylphenyl)methylsulfanyl]ethyl]acetamide chemical structure, C19H23FN2O3S2, CAS 432499-79-1
2-(4-Fluoro-N-methylsulfonylanilino)-N-[2-[(3-methylphenyl)methylsulfanyl]ethyl]acetamide
CAS 432499-79-1C19H23FN2O3S2
2-(2,5-Dimethoxy-N-methylsulfonylanilino)-N-[2-[(3-methylphenyl)methylsulfanyl]ethyl]acetamide chemical structure, C21H28N2O5S2, CAS 432514-39-1
2-(2,5-Dimethoxy-N-methylsulfonylanilino)-N-[2-[(3-methylphenyl)methylsulfanyl]ethyl]acetamide
CAS 432514-39-1C21H28N2O5S2
2-(2,5-Dimethyl-N-methylsulfonylanilino)-N-[2-[(3-methylphenyl)methylsulfanyl]ethyl]acetamide chemical structure, C21H28N2O3S2, CAS 432522-56-0
2-(2,5-Dimethyl-N-methylsulfonylanilino)-N-[2-[(3-methylphenyl)methylsulfanyl]ethyl]acetamide
CAS 432522-56-0C21H28N2O3S2
2-(3-Methyl-N-methylsulfonylanilino)-N-[2-[(4-methylphenyl)methylsulfanyl]ethyl]acetamide chemical structure, C20H26N2O3S2, CAS 6485-23-0
2-(3-Methyl-N-methylsulfonylanilino)-N-[2-[(4-methylphenyl)methylsulfanyl]ethyl]acetamide
CAS 6485-23-0C20H26N2O3S2
2-(2-Ethoxy-N-methylsulfonylanilino)-N-[2-[(3-methylphenyl)methylsulfanyl]ethyl]acetamide chemical structure, C21H28N2O4S2, CAS 432540-48-2
2-(2-Ethoxy-N-methylsulfonylanilino)-N-[2-[(3-methylphenyl)methylsulfanyl]ethyl]acetamide
CAS 432540-48-2C21H28N2O4S2
N-[2-[(2,4-Dichlorophenyl)methylsulfanyl]ethyl]-2-(N-methylsulfonylanilino)propanamide chemical structure, C19H22Cl2N2O3S2, CAS 474085-22-8
N-[2-[(2,4-Dichlorophenyl)methylsulfanyl]ethyl]-2-(N-methylsulfonylanilino)propanamide
CAS 474085-22-8C19H22Cl2N2O3S2
N-[2-[(2-Chlorophenyl)methylsulfanyl]ethyl]-2-(4-fluoro-N-methylsulfonylanilino)acetamide chemical structure, C18H20ClFN2O3S2, CAS 444059-18-1
N-[2-[(2-Chlorophenyl)methylsulfanyl]ethyl]-2-(4-fluoro-N-methylsulfonylanilino)acetamide
CAS 444059-18-1C18H20ClFN2O3S2
2-(4-Chloro-N-methylsulfonylanilino)-N-[2-[(3-methylphenyl)methylsulfanyl]ethyl]propanamide chemical structure, C20H25ClN2O3S2, CAS 5475-18-3
2-(4-Chloro-N-methylsulfonylanilino)-N-[2-[(3-methylphenyl)methylsulfanyl]ethyl]propanamide
CAS 5475-18-3C20H25ClN2O3S2