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Murcko scaffold

Ring system with 3 rings and 26 atoms

13 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
26
Chemicals
13
With full pages
12
Scaffold SMILES

O=C(Cc1ccccc1)Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cc1ccccc1)Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

N-(4-{[(4,6-Dimethyl-2-pyrimidinyl)amino]sulfonyl}phenyl)-2-(4-methoxyphenyl)acetamide chemical structure, C21H22N4O4S, CAS 315671-60-4
N-(4-{[(4,6-Dimethyl-2-pyrimidinyl)amino]sulfonyl}phenyl)-2-(4-methoxyphenyl)acetamide
CAS 315671-60-4C21H22N4O4S
N-{4-[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-2-phenylacetamide chemical structure, C20H20N4O3S, CAS 102157-98-2
N-{4-[(4,6-Dimethylpyrimidin-2-yl)sulfamoyl]phenyl}-2-phenylacetamide
CAS 102157-98-2C20H20N4O3S
2-(4-Methylphenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]acetamide chemical structure, C19H18N4O3S, CAS 587843-94-5
2-(4-Methylphenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]acetamide
CAS 587843-94-5C19H18N4O3S
2-(2-Chloro-6-fluorophenyl)-N-[4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl]acetamide chemical structure, C19H16ClFN4O3S, CAS 710988-72-0
2-(2-Chloro-6-fluorophenyl)-N-[4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl]acetamide
CAS 710988-72-0C19H16ClFN4O3S
2-(3,4-Dimethoxy-phenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide chemical structure, C20H20N4O5S, CAS 546107-30-6
2-(3,4-Dimethoxy-phenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide
CAS 546107-30-6C20H20N4O5S
2-(4-Chloro-phenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide chemical structure, C18H15ClN4O3S, CAS 432523-40-5
2-(4-Chloro-phenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)-phenyl]-acetamide
CAS 432523-40-5C18H15ClN4O3S
2-(4-Fluorophenyl)-N-{4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl}acetamide chemical structure, C19H17FN4O3S, CAS 432520-62-2
2-(4-Fluorophenyl)-N-{4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl}acetamide
CAS 432520-62-2C19H17FN4O3S
N-{4-[(4-Methylpyrimidin-2-yl)sulfamoyl]phenyl}-2-phenylacetamide chemical structure, C19H18N4O3S, CAS 102017-63-0
N-{4-[(4-Methylpyrimidin-2-yl)sulfamoyl]phenyl}-2-phenylacetamide
CAS 102017-63-0C19H18N4O3S
2-(4-Bromophenyl)-N-{4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl}acetamide chemical structure, C19H17BrN4O3S, CAS 349430-93-9
2-(4-Bromophenyl)-N-{4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl}acetamide
CAS 349430-93-9C19H17BrN4O3S
2-(4-Bromophenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]acetamide chemical structure, C18H15BrN4O3S, CAS 432512-78-2
2-(4-Bromophenyl)-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]acetamide
CAS 432512-78-2C18H15BrN4O3S
2-(4-Chlorophenyl)-N-[4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl]acetamide chemical structure, C19H17ClN4O3S, CAS 349430-21-3
2-(4-Chlorophenyl)-N-[4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl]acetamide
CAS 349430-21-3C19H17ClN4O3S
2-Phenyl-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]butanamide chemical structure, C20H20N4O3S, CAS 432527-94-1
2-Phenyl-N-[4-(pyrimidin-2-ylsulfamoyl)phenyl]butanamide
CAS 432527-94-1C20H20N4O3S
2-(2-Methoxyphenyl)-2-methyl-N-{4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl}propanamide chemical structure, C22H24N4O4S, CAS 1368766-63-5
2-(2-Methoxyphenyl)-2-methyl-N-{4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl}propanamide
CAS 1368766-63-5C22H24N4O4S