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Murcko scaffold

Ring system with 3 rings and 22 atoms

10 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
10
With full pages
3
Scaffold SMILES

O=C1CCCN1c1ccc(S(=O)(=O)Nc2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CCCN1c1ccc(S(=O)(=O)Nc2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

N-(3-Chloro-4-fluorophenyl)-4-(2-oxopyrrolidin-1-yl)benzenesulfonamide chemical structure, C16H14ClFN2O3S, CAS 385381-50-0
N-(3-Chloro-4-fluorophenyl)-4-(2-oxopyrrolidin-1-yl)benzenesulfonamide
CAS 385381-50-0C16H14ClFN2O3S
N-(3,4-Dichloro-phenyl)-4-(2-oxo-pyrrolidin-1-yl)-benzenesulfonamide chemical structure, C16H14Cl2N2O3S, CAS 447409-19-0
N-(3,4-Dichloro-phenyl)-4-(2-oxo-pyrrolidin-1-yl)-benzenesulfonamide
CAS 447409-19-0C16H14Cl2N2O3S
N-(2-Methylphenyl)-4-(2-oxopyrrolidin-1-yl)benzenesulfonamide chemical structure, C17H18N2O3S, CAS 447409-22-5
N-(2-Methylphenyl)-4-(2-oxopyrrolidin-1-yl)benzenesulfonamide
CAS 447409-22-5C17H18N2O3S
2,6-Dimethyl-N-(2-methylphenyl)-4-(2-oxopyrrolidin-1-yl)benzenesulfonamide chemical structure, C19H22N2O3S, CAS 540514-67-8
2,6-Dimethyl-N-(2-methylphenyl)-4-(2-oxopyrrolidin-1-yl)benzenesulfonamide
CAS 540514-67-8C19H22N2O3S
N-(2-Cyano-3,5-dimethylphenyl)-4-(2-oxopyrrolidin-1-yl)benzenesulfonamide chemical structure, C19H19N3O3S, CAS 695213-19-5
N-(2-Cyano-3,5-dimethylphenyl)-4-(2-oxopyrrolidin-1-yl)benzenesulfonamide
CAS 695213-19-5C19H19N3O3S
N-(2,6-Dimethylphenyl)-2-methyl-4-(2-oxopyrrolidin-1-yl)benzenesulfonamide chemical structure, C19H22N2O3S, CAS 695207-36-4
N-(2,6-Dimethylphenyl)-2-methyl-4-(2-oxopyrrolidin-1-yl)benzenesulfonamide
CAS 695207-36-4C19H22N2O3S
N-(3-Fluoro-2-methylphenyl)-4-(2-oxopyrrolidin-1-yl)benzenesulfonamide chemical structure, C17H17FN2O3S, CAS 696605-47-7
N-(3-Fluoro-2-methylphenyl)-4-(2-oxopyrrolidin-1-yl)benzenesulfonamide
CAS 696605-47-7C17H17FN2O3S
3-Nitro-4-(2-oxopyrrolidin-1-yl)-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide chemical structure, C17H14F3N3O5S, CAS 371946-34-8
3-Nitro-4-(2-oxopyrrolidin-1-yl)-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide
CAS 371946-34-8C17H14F3N3O5S
1-[4-({[2-(Trifluoromethyl)phenyl]amino}sulfonyl)phenyl]pyrrolidin-2-one chemical structure, C17H15F3N2O3S, CAS 919657-19-5
1-[4-({[2-(Trifluoromethyl)phenyl]amino}sulfonyl)phenyl]pyrrolidin-2-one
CAS 919657-19-5C17H15F3N2O3S
1-{4-[(2-Chloro-4-methylphenyl)sulfamoyl]phenyl}-5-oxopyrrolidine-3-carboxylic acid chemical structure, C18H17ClN2O5S, CAS 1210255-24-5
1-{4-[(2-Chloro-4-methylphenyl)sulfamoyl]phenyl}-5-oxopyrrolidine-3-carboxylic acid
CAS 1210255-24-5C18H17ClN2O5S