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Murcko scaffold

Ring system with 3 rings and 20 atoms

26 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 20
Chemicals: 26
With full pages: 6

Scaffold SMILES

O=C(CSc1nc2sccc2c(=O)[nH]1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(CSc1nc2sccc2c(=O)[nH]1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

2-[(4-Hydroxy-5,6-dimethylthieno[2,3-d]pyrimidin-2-yl)sulfanyl]-1-(4-methylphenyl)ethanone chemical structure, C17H16N2O2S2, CAS 294893-12-2

2-[(4-Hydroxy-5,6-dimethylthieno[2,3-d]pyrimidin-2-yl)sulfanyl]-1-(4-methylphenyl)ethanone

CAS 294893-12-2C₁₇H₁₆N₂O₂S₂

3-Allyl-6-ethyl-2-((2-oxo-2-(p-tolyl)ethyl)thio)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C20H20N2O2S2, CAS 421577-88-0

3-Allyl-6-ethyl-2-((2-oxo-2-(p-tolyl)ethyl)thio)thieno[2,3-d]pyrimidin-4(3H)-one

CAS 421577-88-0C₂₀H₂₀N₂O₂S₂

2-{[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl}-3-ethyl-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C18H17ClN2O2S2, CAS 586996-60-3

2-{[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl}-3-ethyl-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one

CAS 586996-60-3C₁₈H₁₇ClN₂O₂S₂

3-Ethyl-2-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C19H20N2O3S2, CAS 667884-65-3

3-Ethyl-2-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one

CAS 667884-65-3C₁₉H₂₀N₂O₃S₂

5,6-Dimethyl-2-[(2-oxo-2-phenylethyl)sulfanyl]-3-(prop-2-en-1-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one chemical structure, C19H18N2O2S2, CAS 314245-32-4

5,6-Dimethyl-2-[(2-oxo-2-phenylethyl)sulfanyl]-3-(prop-2-en-1-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one

CAS 314245-32-4C₁₉H₁₈N₂O₂S₂

2-{[2-(4-Methoxyphenyl)-2-oxoethyl]sulfanyl}-5,6-dimethyl-3-(prop-2-en-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C20H20N2O3S2, CAS 625822-40-4

2-{[2-(4-Methoxyphenyl)-2-oxoethyl]sulfanyl}-5,6-dimethyl-3-(prop-2-en-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one

CAS 625822-40-4C₂₀H₂₀N₂O₃S₂

2-{[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl}-5,6-dimethyl-3-(prop-2-en-1-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one chemical structure, C19H17ClN2O2S2, CAS 496026-44-9

2-{[2-(4-Chlorophenyl)-2-oxoethyl]sulfanyl}-5,6-dimethyl-3-(prop-2-en-1-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one

CAS 496026-44-9C₁₉H₁₇ClN₂O₂S₂

6-Ethyl-2-[(2-oxo-2-phenylethyl)sulfanyl]-3-(prop-2-en-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C19H18N2O2S2, CAS 406200-97-3

6-Ethyl-2-[(2-oxo-2-phenylethyl)sulfanyl]-3-(prop-2-en-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one

CAS 406200-97-3C₁₉H₁₈N₂O₂S₂

3-Allyl-2-((2-(4-chlorophenyl)-2-oxoethyl)thio)-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C19H17ClN2O2S2, CAS 380335-46-6

3-Allyl-2-((2-(4-chlorophenyl)-2-oxoethyl)thio)-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one

CAS 380335-46-6C₁₉H₁₇ClN₂O₂S₂

3-Allyl-6-ethyl-2-((2-(4-fluorophenyl)-2-oxoethyl)thio)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C19H17FN2O2S2, CAS 421577-90-4

3-Allyl-6-ethyl-2-((2-(4-fluorophenyl)-2-oxoethyl)thio)thieno[2,3-d]pyrimidin-4(3H)-one

CAS 421577-90-4C₁₉H₁₇FN₂O₂S₂

3-Allyl-6-ethyl-2-((2-(4-methoxyphenyl)-2-oxoethyl)thio)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C20H20N2O3S2, CAS 421577-91-5

3-Allyl-6-ethyl-2-((2-(4-methoxyphenyl)-2-oxoethyl)thio)thieno[2,3-d]pyrimidin-4(3H)-one

CAS 421577-91-5C₂₀H₂₀N₂O₃S₂

3-Allyl-2-((2-(4-bromophenyl)-2-oxoethyl)thio)-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C19H17BrN2O2S2, CAS 421577-89-1

3-Allyl-2-((2-(4-bromophenyl)-2-oxoethyl)thio)-6-ethylthieno[2,3-d]pyrimidin-4(3H)-one

CAS 421577-89-1C₁₉H₁₇BrN₂O₂S₂

3-ET-2-((2-Mesityl-2-oxoethyl)thio)-5,6-dimethylthieno(2,3-D)pyrimidin-4(3H)-one chemical structure, C21H24N2O2S2, CAS 578751-54-9

3-ET-2-((2-Mesityl-2-oxoethyl)thio)-5,6-dimethylthieno(2,3-D)pyrimidin-4(3H)-one

CAS 578751-54-9C₂₁H₂₄N₂O₂S₂

2-{[2-(4-Fluorophenyl)-2-oxoethyl]sulfanyl}-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C17H15FN2O2S2, CAS 578755-49-4

2-{[2-(4-Fluorophenyl)-2-oxoethyl]sulfanyl}-3,5,6-trimethylthieno[2,3-d]pyrimidin-4(3H)-one

CAS 578755-49-4C₁₇H₁₅FN₂O₂S₂

2-{[2-(3,4-Dichlorophenyl)-2-oxoethyl]sulfanyl}-3-ethyl-5,6-dimethylthieno[2,3-D]pyrimidin-4(3H)-one chemical structure, C18H16Cl2N2O2S2, CAS 585563-60-6

2-{[2-(3,4-Dichlorophenyl)-2-oxoethyl]sulfanyl}-3-ethyl-5,6-dimethylthieno[2,3-D]pyrimidin-4(3H)-one

CAS 585563-60-6C₁₈H₁₆Cl₂N₂O₂S₂

3-Ethyl-2-{[2-(4-fluorophenyl)-2-oxoethyl]sulfanyl}-5,6-dimethylthieno[2,3-D]pyrimidin-4(3H)-one chemical structure, C18H17FN2O2S2, CAS 618427-52-4

3-Ethyl-2-{[2-(4-fluorophenyl)-2-oxoethyl]sulfanyl}-5,6-dimethylthieno[2,3-D]pyrimidin-4(3H)-one

CAS 618427-52-4C₁₈H₁₇FN₂O₂S₂

2-{[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]sulfanyl}-3-ethyl-5,6-dimethylthieno[2,3-D]pyrimidin-4(3H)-one chemical structure, C20H22N2O4S2, CAS 618427-54-6

2-{[2-(3,4-Dimethoxyphenyl)-2-oxoethyl]sulfanyl}-3-ethyl-5,6-dimethylthieno[2,3-D]pyrimidin-4(3H)-one

CAS 618427-54-6C₂₀H₂₂N₂O₄S₂

3-ET-5,6-Dimethyl-2-((2-oxo-2-phenylethyl)thio)thieno(2,3-D)pyrimidin-4(3H)-one chemical structure, C18H18N2O2S2, CAS 335399-66-1

3-ET-5,6-Dimethyl-2-((2-oxo-2-phenylethyl)thio)thieno(2,3-D)pyrimidin-4(3H)-one

CAS 335399-66-1C₁₈H₁₈N₂O₂S₂

2-{[2-(4-Fluorophenyl)-2-oxoethyl]sulfanyl}-5,6-dimethyl-3-(prop-2-en-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C19H17FN2O2S2, CAS 510724-70-6

2-{[2-(4-Fluorophenyl)-2-oxoethyl]sulfanyl}-5,6-dimethyl-3-(prop-2-en-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one

CAS 510724-70-6C₁₉H₁₇FN₂O₂S₂

2-[2-(3,4-Dimethylphenyl)-2-oxoethyl]sulfanyl-5,6-dimethyl-3-prop-2-enylthieno[2,3-d]pyrimidin-4-one chemical structure, C21H22N2O2S2, CAS 708285-28-3

2-[2-(3,4-Dimethylphenyl)-2-oxoethyl]sulfanyl-5,6-dimethyl-3-prop-2-enylthieno[2,3-d]pyrimidin-4-one

CAS 708285-28-3C₂₁H₂₂N₂O₂S₂

2-{[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl}-5,6-dimethyl-3-(prop-2-en-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one chemical structure, C19H17BrN2O2S2, CAS 677759-80-7

2-{[2-(4-Bromophenyl)-2-oxoethyl]sulfanyl}-5,6-dimethyl-3-(prop-2-en-1-yl)thieno[2,3-d]pyrimidin-4(3H)-one

CAS 677759-80-7C₁₉H₁₇BrN₂O₂S₂

5,6-Dimethyl-2-phenacylsulfanyl-3H-thieno[2,3-d]pyrimidin-4-one chemical structure, C16H14N2O2S2, CAS 52881-19-3

5,6-Dimethyl-2-phenacylsulfanyl-3H-thieno[2,3-d]pyrimidin-4-one

CAS 52881-19-3C₁₆H₁₄N₂O₂S₂

Ethyl 3-amino-2-[2-(4-bromophenyl)-2-oxoethyl]sulfanyl-5-methyl-4-oxothieno[2,3-d]pyrimidine-6-carboxylate chemical structure, C18H16BrN3O4S2, CAS 865655-28-3

Ethyl 3-amino-2-[2-(4-bromophenyl)-2-oxoethyl]sulfanyl-5-methyl-4-oxothieno[2,3-d]pyrimidine-6-carboxylate

CAS 865655-28-3C₁₈H₁₆BrN₃O₄S₂

2-{[2-(2-Chlorophenyl)-2-oxoethyl]sulfanyl}-5,6-dimethyl-3-(prop-2-en-1-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one chemical structure, C19H17ClN2O2S2, CAS 880801-31-0

2-{[2-(2-Chlorophenyl)-2-oxoethyl]sulfanyl}-5,6-dimethyl-3-(prop-2-en-1-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one

CAS 880801-31-0C₁₉H₁₇ClN₂O₂S₂