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Murcko scaffold

4-(Oxolane-2-carbonyl)-N-phenylpiperazine-1-carbothioamide scaffold

29 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
29
With full pages
23
Scaffold SMILES

O=C(C1CCCO1)N1CCN(C(=S)Nc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-(Oxolane-2-carbonyl)-N-phenylpiperazine-1-carbothioamide page
Murcko scaffold O=C(C1CCCO1)N1CCN(C(=S)Nc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 29 of 29 chemicals

N-(4-Nitrophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide chemical structure, C16H20N4O4S, CAS 430469-49-1
N-(4-Nitrophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide
CAS 430469-49-1C16H20N4O4S
N-(4-Methoxyphenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide chemical structure, C17H23N3O3S, CAS 431054-31-8
N-(4-Methoxyphenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide
CAS 431054-31-8C17H23N3O3S
N-(4-Methylphenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide chemical structure, C17H23N3O2S, CAS 431073-52-8
N-(4-Methylphenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide
CAS 431073-52-8C17H23N3O2S
N-(3-Chlorophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide chemical structure, C16H20ClN3O2S, CAS 431883-26-0
N-(3-Chlorophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide
CAS 431883-26-0C16H20ClN3O2S
N-(4-Chlorophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide chemical structure, C16H20ClN3O2S, CAS 431884-18-3
N-(4-Chlorophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide
CAS 431884-18-3C16H20ClN3O2S
N-(2-Methylphenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide chemical structure, C17H23N3O2S, CAS 431886-58-7
N-(2-Methylphenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide
CAS 431886-58-7C17H23N3O2S
N-(4-Fluorophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide chemical structure, C16H20FN3O2S, CAS 431892-30-7
N-(4-Fluorophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide
CAS 431892-30-7C16H20FN3O2S
N-(2,4-Dichlorophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide chemical structure, C16H19Cl2N3O2S, CAS 431892-34-1
N-(2,4-Dichlorophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide
CAS 431892-34-1C16H19Cl2N3O2S
N-(2-Fluorophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide chemical structure, C16H20FN3O2S, CAS 431919-16-3
N-(2-Fluorophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide
CAS 431919-16-3C16H20FN3O2S
N-(3-Methylphenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide chemical structure, C17H23N3O2S, CAS 431920-33-1
N-(3-Methylphenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide
CAS 431920-33-1C17H23N3O2S
N-(3,4-Dichlorophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide chemical structure, C16H19Cl2N3O2S, CAS 431921-06-1
N-(3,4-Dichlorophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide
CAS 431921-06-1C16H19Cl2N3O2S
4-(Oxolane-2-carbonyl)-N-phenylpiperazine-1-carbothioamide chemical structure, C16H21N3O2S, CAS 431923-66-9
4-(Oxolane-2-carbonyl)-N-phenylpiperazine-1-carbothioamide
CAS 431923-66-9C16H21N3O2S
N-(2-Methoxyphenyl)-4-(tetrahydro-2-furanylcarbonyl)-1-piperazinecarbothioamide chemical structure, C17H23N3O3S, CAS 516458-56-3
N-(2-Methoxyphenyl)-4-(tetrahydro-2-furanylcarbonyl)-1-piperazinecarbothioamide
CAS 516458-56-3C17H23N3O3S
N-(4-Bromophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide chemical structure, C16H20BrN3O2S, CAS 690690-28-9
N-(4-Bromophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide
CAS 690690-28-9C16H20BrN3O2S
N-(3-Fluorophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide chemical structure, C16H20FN3O2S, CAS 690693-72-2
N-(3-Fluorophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide
CAS 690693-72-2C16H20FN3O2S
4-(Oxolane-2-carbonyl)-N-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide chemical structure, C17H20F3N3O2S, CAS 690693-83-5
4-(Oxolane-2-carbonyl)-N-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide
CAS 690693-83-5C17H20F3N3O2S
N-(4-Chloro-2-methylphenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide chemical structure, C17H22ClN3O2S, CAS 664969-11-3
N-(4-Chloro-2-methylphenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide
CAS 664969-11-3C17H22ClN3O2S
N-(4-Chloro-2,5-dimethoxyphenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide chemical structure, C18H24ClN3O4S, CAS 664968-58-5
N-(4-Chloro-2,5-dimethoxyphenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide
CAS 664968-58-5C18H24ClN3O4S
N-(3,5-Dimethoxyphenyl)-4-(tetrahydrofuran-2-ylcarbonyl)piperazine-1-carbothioamide chemical structure, C18H25N3O4S, CAS 664969-16-8
N-(3,5-Dimethoxyphenyl)-4-(tetrahydrofuran-2-ylcarbonyl)piperazine-1-carbothioamide
CAS 664969-16-8C18H25N3O4S
Ethyl 4-[[4-(oxolane-2-carbonyl)piperazine-1-carbothioyl]amino]benzoate chemical structure, C19H25N3O4S, CAS 664969-12-4
Ethyl 4-[[4-(oxolane-2-carbonyl)piperazine-1-carbothioyl]amino]benzoate
CAS 664969-12-4C19H25N3O4S
N-(4-Butylphenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide chemical structure, C20H29N3O2S, CAS 627063-60-9
N-(4-Butylphenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide
CAS 627063-60-9C20H29N3O2S
N-(3-Chloro-2-methylphenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide chemical structure, C17H22ClN3O2S, CAS 664969-10-2
N-(3-Chloro-2-methylphenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide
CAS 664969-10-2C17H22ClN3O2S
Methyl [4-({[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]carbonothioyl}amino)phenyl]acetate chemical structure, C19H25N3O4S, CAS 516458-55-2
Methyl [4-({[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]carbonothioyl}amino)phenyl]acetate
CAS 516458-55-2C19H25N3O4S
N-(2-Methoxy-4-nitrophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide chemical structure, C17H22N4O5S, CAS 701281-51-8
N-(2-Methoxy-4-nitrophenyl)-4-(oxolane-2-carbonyl)piperazine-1-carbothioamide
CAS 701281-51-8C17H22N4O5S