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Murcko scaffold

5-(4-Benzyloxybenzylidene)-2-thioxothiazolidin-4-one scaffold

97 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
97
With full pages
3
Scaffold SMILES

O=C1NC(=S)SC1=Cc1ccc(OCc2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 5-(4-Benzyloxybenzylidene)-2-thioxothiazolidin-4-one page
Murcko scaffold O=C1NC(=S)SC1=Cc1ccc(OCc2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 97 chemicals

3-{(5Z)-5-[4-(Benzyloxy)-3-methoxybenzylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}propanoic acid chemical structure, C21H19NO5S2, CAS 302949-54-8
3-{(5Z)-5-[4-(Benzyloxy)-3-methoxybenzylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}propanoic acid
CAS 302949-54-8C21H19NO5S2
2-[(5E)-5-[(4-Benzyloxy-3-methoxy-phenyl)methylene]-4-oxo-2-thioxo-thiazolidin-3-yl]acetic acid chemical structure, C20H17NO5S2, CAS 161192-44-5
2-[(5E)-5-[(4-Benzyloxy-3-methoxy-phenyl)methylene]-4-oxo-2-thioxo-thiazolidin-3-yl]acetic acid
CAS 161192-44-5C20H17NO5S2
((5E)-5-{4-[(4-Chlorobenzyl)oxy]-3-methoxybenzylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)acetic acid chemical structure, C20H16ClNO5S2, CAS 313964-71-5
((5E)-5-{4-[(4-Chlorobenzyl)oxy]-3-methoxybenzylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)acetic acid
CAS 313964-71-5C20H16ClNO5S2
[(5E)-5-{4-[(2-Chlorobenzyl)oxy]-3-methoxybenzylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid chemical structure, C20H16ClNO5S2, CAS 314036-16-3
[(5E)-5-{4-[(2-Chlorobenzyl)oxy]-3-methoxybenzylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
CAS 314036-16-3C20H16ClNO5S2
5-(4-Benzyloxy-benzylidene)-2-thioxo-thiazolidin-4-one chemical structure, C17H13NO2S2, CAS 168550-07-0
5-(4-Benzyloxy-benzylidene)-2-thioxo-thiazolidin-4-one
CAS 168550-07-0C17H13NO2S2
3-Allyl-5-{4-[(4-chlorobenzyl)oxy]-3-methoxybenzylidene}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C21H18ClNO3S2, CAS 331736-64-2
3-Allyl-5-{4-[(4-chlorobenzyl)oxy]-3-methoxybenzylidene}-2-thioxo-1,3-thiazolidin-4-one
CAS 331736-64-2C21H18ClNO3S2
[(5E)-5-{4-[(4-Bromobenzyl)oxy]-3-methoxybenzylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid chemical structure, C20H16BrNO5S2, CAS 346633-78-1
[(5E)-5-{4-[(4-Bromobenzyl)oxy]-3-methoxybenzylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
CAS 346633-78-1C20H16BrNO5S2
(5E)-5-[[4-[(2-Fluorophenyl)methoxy]-3-methoxyphenyl]methylidene]-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C21H18FNO3S2, CAS 309936-32-1
(5E)-5-[[4-[(2-Fluorophenyl)methoxy]-3-methoxyphenyl]methylidene]-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 309936-32-1C21H18FNO3S2
(5E)-5-({3-Chloro-4-[(4-fluorophenyl)methoxy]phenyl}methylidene)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C17H11ClFNO2S2, CAS 297150-44-8
(5E)-5-({3-Chloro-4-[(4-fluorophenyl)methoxy]phenyl}methylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 297150-44-8C17H11ClFNO2S2
(5E)-5-[[3-Chloro-5-methoxy-4-[(3-methylphenyl)methoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C19H16ClNO3S2, CAS 429641-26-9
(5E)-5-[[3-Chloro-5-methoxy-4-[(3-methylphenyl)methoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 429641-26-9C19H16ClNO3S2
(5E)-5-[[3-Methoxy-4-[(2-methylphenyl)methoxy]phenyl]methylidene]-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C22H21NO3S2, CAS 429642-97-7
(5E)-5-[[3-Methoxy-4-[(2-methylphenyl)methoxy]phenyl]methylidene]-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 429642-97-7C22H21NO3S2
(5E)-5-[[3-Chloro-5-methoxy-4-[(2-methylphenyl)methoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H18ClNO3S2, CAS 429643-14-1
(5E)-5-[[3-Chloro-5-methoxy-4-[(2-methylphenyl)methoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 429643-14-1C20H18ClNO3S2
(5E)-5-[[3-Ethoxy-4-[(2-methylphenyl)methoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C21H21NO3S2, CAS 429646-58-2
(5E)-5-[[3-Ethoxy-4-[(2-methylphenyl)methoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 429646-58-2C21H21NO3S2
(5E)-5-[[3-Ethoxy-4-[(3-methylphenyl)methoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C21H21NO3S2, CAS 429649-24-1
(5E)-5-[[3-Ethoxy-4-[(3-methylphenyl)methoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 429649-24-1C21H21NO3S2
(5E)-5-[[3-Methoxy-4-[(4-methylphenyl)methoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H19NO3S2, CAS 429649-25-2
(5E)-5-[[3-Methoxy-4-[(4-methylphenyl)methoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 429649-25-2C20H19NO3S2
(5E)-5-[[3-Methoxy-4-[(4-methylphenyl)methoxy]phenyl]methylidene]-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C22H21NO3S2, CAS 429651-31-0
(5E)-5-[[3-Methoxy-4-[(4-methylphenyl)methoxy]phenyl]methylidene]-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 429651-31-0C22H21NO3S2
(5E)-5-[[3-Ethoxy-4-[(4-methylphenyl)methoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C21H21NO3S2, CAS 430441-81-9
(5E)-5-[[3-Ethoxy-4-[(4-methylphenyl)methoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 430441-81-9C21H21NO3S2
(5E)-5-[[3-Bromo-5-methoxy-4-[(2-methylphenyl)methoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H18BrNO3S2, CAS 430442-27-6
(5E)-5-[[3-Bromo-5-methoxy-4-[(2-methylphenyl)methoxy]phenyl]methylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 430442-27-6C20H18BrNO3S2
(5Z)-5-[[3-Methoxy-4-[(4-methylphenyl)methoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C19H17NO3S2, CAS 362002-22-0
(5Z)-5-[[3-Methoxy-4-[(4-methylphenyl)methoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 362002-22-0C19H17NO3S2
(5E)-5-[[4-[(4-Chlorophenyl)methoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C17H12ClNO2S2, CAS 172931-49-6
(5E)-5-[[4-[(4-Chlorophenyl)methoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 172931-49-6C17H12ClNO2S2
[(5E)-5-{4-[(4-Chlorobenzyl)oxy]-3-ethoxybenzylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid chemical structure, C21H18ClNO5S2, CAS 303134-37-4
[(5E)-5-{4-[(4-Chlorobenzyl)oxy]-3-ethoxybenzylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
CAS 303134-37-4C21H18ClNO5S2
Methyl 3-{(5Z)-5-[4-(benzyloxy)-3-methoxybenzylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}propanoate chemical structure, C22H21NO5S2, CAS 303117-40-0
Methyl 3-{(5Z)-5-[4-(benzyloxy)-3-methoxybenzylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}propanoate
CAS 303117-40-0C22H21NO5S2
Methyl 3-[(5Z)-5-{4-[(2-chlorobenzyl)oxy]-3-methoxybenzylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoate chemical structure, C22H20ClNO5S2, CAS 303117-41-1
Methyl 3-[(5Z)-5-{4-[(2-chlorobenzyl)oxy]-3-methoxybenzylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoate
CAS 303117-41-1C22H20ClNO5S2
(5E)-5-[[3-Chloro-5-ethoxy-4-[(4-fluorophenyl)methoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C19H15ClFNO3S2, CAS 299909-24-3
(5E)-5-[[3-Chloro-5-ethoxy-4-[(4-fluorophenyl)methoxy]phenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 299909-24-3C19H15ClFNO3S2