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Murcko scaffold

Ring system with 3 rings and 22 atoms

27 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
27
With full pages
12
Scaffold SMILES

O=C(c1ccco1)N1CCN(C(=S)Nc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(c1ccco1)N1CCN(C(=S)Nc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

N-(2,4-Dimethylphenyl)-4-(furan-2-carbonyl)piperazine-1-carbothioamide chemical structure, C18H21N3O2S, CAS 433307-60-9
N-(2,4-Dimethylphenyl)-4-(furan-2-carbonyl)piperazine-1-carbothioamide
CAS 433307-60-9C18H21N3O2S
N-(3-Fluorophenyl)-4-(furan-2-carbonyl)piperazine-1-carbothioamide chemical structure, C16H16FN3O2S, CAS 690693-71-1
N-(3-Fluorophenyl)-4-(furan-2-carbonyl)piperazine-1-carbothioamide
CAS 690693-71-1C16H16FN3O2S
N-(2-Chlorophenyl)-4-(furan-2-carbonyl)piperazine-1-carbothioamide chemical structure, C16H16ClN3O2S, CAS 690693-86-8
N-(2-Chlorophenyl)-4-(furan-2-carbonyl)piperazine-1-carbothioamide
CAS 690693-86-8C16H16ClN3O2S
4-(Furan-2-carbonyl)-N-(2-methylphenyl)piperazine-1-carbothioamide chemical structure, C17H19N3O2S, CAS 478970-71-7
4-(Furan-2-carbonyl)-N-(2-methylphenyl)piperazine-1-carbothioamide
CAS 478970-71-7C17H19N3O2S
4-(Furan-2-carbonyl)-N-(3-methoxyphenyl)piperazine-1-carbothioamide chemical structure, C17H19N3O3S, CAS 435334-14-8
4-(Furan-2-carbonyl)-N-(3-methoxyphenyl)piperazine-1-carbothioamide
CAS 435334-14-8C17H19N3O3S
4-(Furan-2-carbonyl)-N-(2-methoxyphenyl)piperazine-1-carbothioamide chemical structure, C17H19N3O3S, CAS 667445-79-6
4-(Furan-2-carbonyl)-N-(2-methoxyphenyl)piperazine-1-carbothioamide
CAS 667445-79-6C17H19N3O3S
N-(2,4-Dimethoxyphenyl)-4-(furan-2-carbonyl)piperazine-1-carbothioamide chemical structure, C18H21N3O4S, CAS 433312-94-8
N-(2,4-Dimethoxyphenyl)-4-(furan-2-carbonyl)piperazine-1-carbothioamide
CAS 433312-94-8C18H21N3O4S
4-(Furan-2-carbonyl)-N-(3-nitrophenyl)piperazine-1-carbothioamide chemical structure, C16H16N4O4S, CAS 725243-76-5
4-(Furan-2-carbonyl)-N-(3-nitrophenyl)piperazine-1-carbothioamide
CAS 725243-76-5C16H16N4O4S
4-(Furan-2-carbonyl)-N-(3-methylphenyl)piperazine-1-carbothioamide chemical structure, C17H19N3O2S, CAS 479596-78-6
4-(Furan-2-carbonyl)-N-(3-methylphenyl)piperazine-1-carbothioamide
CAS 479596-78-6C17H19N3O2S
N-(2,4-Dichlorophenyl)-4-(furan-2-carbonyl)piperazine-1-carbothioamide chemical structure, C16H15Cl2N3O2S, CAS 502758-83-0
N-(2,4-Dichlorophenyl)-4-(furan-2-carbonyl)piperazine-1-carbothioamide
CAS 502758-83-0C16H15Cl2N3O2S
Ethyl 4-({[4-(2-furylcarbonyl)piperazinyl]thioxomethyl}amino)benzoate chemical structure, C19H21N3O4S, CAS 433315-31-2
Ethyl 4-({[4-(2-furylcarbonyl)piperazinyl]thioxomethyl}amino)benzoate
CAS 433315-31-2C19H21N3O4S
4-{[(2,5-Dimethoxyphenyl)amino]thioxomethyl}piperazinyl 2-furyl ketone chemical structure, C18H21N3O4S, CAS 433321-18-7
4-{[(2,5-Dimethoxyphenyl)amino]thioxomethyl}piperazinyl 2-furyl ketone
CAS 433321-18-7C18H21N3O4S
4-{[(3,5-Dimethoxyphenyl)amino]thioxomethyl}piperazinyl 2-furyl ketone chemical structure, C18H21N3O4S, CAS 433323-87-6
4-{[(3,5-Dimethoxyphenyl)amino]thioxomethyl}piperazinyl 2-furyl ketone
CAS 433323-87-6C18H21N3O4S
N-(4-Chloro-2-methylphenyl)-4-(furan-2-carbonyl)piperazine-1-carbothioamide chemical structure, C17H18ClN3O2S, CAS 433258-28-7
N-(4-Chloro-2-methylphenyl)-4-(furan-2-carbonyl)piperazine-1-carbothioamide
CAS 433258-28-7C17H18ClN3O2S
4-(Furan-2-carbonyl)-N-(4-sulfamoylphenyl)piperazine-1-carbothioamide chemical structure, C16H18N4O4S2, CAS 693254-22-7
4-(Furan-2-carbonyl)-N-(4-sulfamoylphenyl)piperazine-1-carbothioamide
CAS 693254-22-7C16H18N4O4S2
N-(3-Chloro-4-fluorophenyl)-4-(furan-2-carbonyl)piperazine-1-carbothioamide chemical structure, C16H15ClFN3O2S, CAS 708294-80-8
N-(3-Chloro-4-fluorophenyl)-4-(furan-2-carbonyl)piperazine-1-carbothioamide
CAS 708294-80-8C16H15ClFN3O2S
Methyl 2-({[4-(2-furoyl)-1-piperazinyl]carbothioyl}amino)-4,5-dimethoxybenzoate chemical structure, C20H23N3O6S, CAS 831246-50-5
Methyl 2-({[4-(2-furoyl)-1-piperazinyl]carbothioyl}amino)-4,5-dimethoxybenzoate
CAS 831246-50-5C20H23N3O6S
Dimethyl 2-({[4-(2-furoyl)piperazin-1-yl]carbonothioyl}amino)terephthalate chemical structure, C20H21N3O6S, CAS 847477-79-6
Dimethyl 2-({[4-(2-furoyl)piperazin-1-yl]carbonothioyl}amino)terephthalate
CAS 847477-79-6C20H21N3O6S
Methyl 4-({[4-(2-furylcarbonyl)piperazinyl]thioxomethyl}amino)benzoate chemical structure, C18H19N3O4S, CAS 708282-93-3
Methyl 4-({[4-(2-furylcarbonyl)piperazinyl]thioxomethyl}amino)benzoate
CAS 708282-93-3C18H19N3O4S
Methyl 2-[4-[[4-(furan-2-carbonyl)piperazine-1-carbothioyl]amino]phenyl]acetate chemical structure, C19H21N3O4S, CAS 516457-89-9
Methyl 2-[4-[[4-(furan-2-carbonyl)piperazine-1-carbothioyl]amino]phenyl]acetate
CAS 516457-89-9C19H21N3O4S
N-(3,5-Dimethylphenyl)-4-(furan-2-carbonyl)piperazine-1-carbothioamide chemical structure, C18H21N3O2S, CAS 433256-20-3
N-(3,5-Dimethylphenyl)-4-(furan-2-carbonyl)piperazine-1-carbothioamide
CAS 433256-20-3C18H21N3O2S
4-(Furan-2-carbonyl)-N-(2-methoxy-4-nitrophenyl)piperazine-1-carbothioamide chemical structure, C17H18N4O5S, CAS 708217-78-1
4-(Furan-2-carbonyl)-N-(2-methoxy-4-nitrophenyl)piperazine-1-carbothioamide
CAS 708217-78-1C17H18N4O5S
N-(3,5-Difluorophenyl)-4-(furan-2-carbonyl)piperazine-1-carbothioamide chemical structure, C16H15F2N3O2S, CAS 838903-50-7
N-(3,5-Difluorophenyl)-4-(furan-2-carbonyl)piperazine-1-carbothioamide
CAS 838903-50-7C16H15F2N3O2S
1-Piperazinecarbothioamide, N-(2-cyano-4,5-dimethoxyphenyl)-4-(2-furanylcarbonyl)- chemical structure, C19H20N4O4S, CAS 67817-56-5
1-Piperazinecarbothioamide, N-(2-cyano-4,5-dimethoxyphenyl)-4-(2-furanylcarbonyl)-
CAS 67817-56-5C19H20N4O4S