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Murcko scaffold

1-(4-Benzylpiperazin-1-yl)-2-phenylethanone scaffold

38 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
38
With full pages
6
Scaffold SMILES

O=C(Cc1ccccc1)N1CCN(Cc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(4-Benzylpiperazin-1-yl)-2-phenylethanone page
Murcko scaffold O=C(Cc1ccccc1)N1CCN(Cc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 38 of 38 chemicals

Piperazine, 1-(o-chlorobenzyl)-4-(phenylacetyl)-, hydrochloride chemical structure, C19H22Cl2N2O, CAS 18907-62-5
Piperazine, 1-(o-chlorobenzyl)-4-(phenylacetyl)-, hydrochloride
CAS 18907-62-5C19H22Cl2N2O
1-[4-(2-Chlorobenzyl)piperazin-1-yl]-2-phenylethanone chemical structure, C19H21ClN2O, CAS 425398-20-5
1-[4-(2-Chlorobenzyl)piperazin-1-yl]-2-phenylethanone
CAS 425398-20-5C19H21ClN2O
1-[4-[(4-Methylsulfanylphenyl)methyl]piperazin-1-yl]-2-phenylethanone chemical structure, C20H24N2OS, CAS 461428-48-8
1-[4-[(4-Methylsulfanylphenyl)methyl]piperazin-1-yl]-2-phenylethanone
CAS 461428-48-8C20H24N2OS
1-(4-Benzylpiperazin-1-yl)-2-phenylethanone chemical structure, C19H22N2O, CAS 41465-26-3
1-(4-Benzylpiperazin-1-yl)-2-phenylethanone
CAS 41465-26-3C19H22N2O
1-[4-[(2-Methylphenyl)methyl]piperazin-1-yl]-2-phenylethanone chemical structure, C20H24N2O, CAS 355392-78-8
1-[4-[(2-Methylphenyl)methyl]piperazin-1-yl]-2-phenylethanone
CAS 355392-78-8C20H24N2O
1-[4-(4-Methoxybenzyl)piperazin-1-yl]-2-phenylethanone chemical structure, C20H24N2O2, CAS 354535-94-7
1-[4-(4-Methoxybenzyl)piperazin-1-yl]-2-phenylethanone
CAS 354535-94-7C20H24N2O2
1-[4-(2-Nitrobenzyl)piperazin-1-yl]-2-phenylethanone chemical structure, C19H21N3O3, CAS 354536-10-0
1-[4-(2-Nitrobenzyl)piperazin-1-yl]-2-phenylethanone
CAS 354536-10-0C19H21N3O3
1-[4-[(3-Nitrophenyl)methyl]piperazin-1-yl]-2-phenylethanone chemical structure, C19H21N3O3, CAS 355814-11-8
1-[4-[(3-Nitrophenyl)methyl]piperazin-1-yl]-2-phenylethanone
CAS 355814-11-8C19H21N3O3
1-[4-(2-Fluorobenzyl)piperazin-1-yl]-2-phenylethanone chemical structure, C19H21FN2O, CAS 355814-25-4
1-[4-(2-Fluorobenzyl)piperazin-1-yl]-2-phenylethanone
CAS 355814-25-4C19H21FN2O
1-(4-Benzylpiperazin-1-yl)-2-(2-methoxyphenyl)ethanone chemical structure, C20H24N2O2, CAS 328287-16-7
1-(4-Benzylpiperazin-1-yl)-2-(2-methoxyphenyl)ethanone
CAS 328287-16-7C20H24N2O2
1-[4-[(4-Ethoxyphenyl)methyl]piperazin-1-yl]-2-phenylethanone chemical structure, C21H26N2O2, CAS 425395-31-9
1-[4-[(4-Ethoxyphenyl)methyl]piperazin-1-yl]-2-phenylethanone
CAS 425395-31-9C21H26N2O2
1-(4-Ethylbenzyl)-4-(phenylacetyl)piperazine chemical structure, C21H26N2O, CAS 423745-84-0
1-(4-Ethylbenzyl)-4-(phenylacetyl)piperazine
CAS 423745-84-0C21H26N2O
1-[4-[(3-Fluorophenyl)methyl]piperazin-1-yl]-2-phenylethanone chemical structure, C19H21FN2O, CAS 425391-05-5
1-[4-[(3-Fluorophenyl)methyl]piperazin-1-yl]-2-phenylethanone
CAS 425391-05-5C19H21FN2O
1-[4-(3-Methylbenzyl)piperazin-1-yl]-2-phenylethanone chemical structure, C20H24N2O, CAS 425389-77-1
1-[4-(3-Methylbenzyl)piperazin-1-yl]-2-phenylethanone
CAS 425389-77-1C20H24N2O
1-[4-(4-Fluorobenzyl)piperazin-1-yl]-2-phenylethanone chemical structure, C19H21FN2O, CAS 423743-29-7
1-[4-(4-Fluorobenzyl)piperazin-1-yl]-2-phenylethanone
CAS 423743-29-7C19H21FN2O
1-(4-Chlorobenzyl)-4-(phenylacetyl)piperazine chemical structure, C19H21ClN2O, CAS 423748-78-1
1-(4-Chlorobenzyl)-4-(phenylacetyl)piperazine
CAS 423748-78-1C19H21ClN2O
1-({4-Nitrophenyl}methyl)-4-(phenylacetyl)piperazine chemical structure, C19H21N3O3, CAS 355813-48-8
1-({4-Nitrophenyl}methyl)-4-(phenylacetyl)piperazine
CAS 355813-48-8C19H21N3O3
1-(4-Benzylpiperazin-1-yl)-2-(4-methylphenyl)ethanone chemical structure, C20H24N2O, CAS 510725-92-5
1-(4-Benzylpiperazin-1-yl)-2-(4-methylphenyl)ethanone
CAS 510725-92-5C20H24N2O
1-[4-[(3-Bromophenyl)methyl]piperazin-1-yl]-2-phenylethanone chemical structure, C19H21BrN2O, CAS 355814-30-1
1-[4-[(3-Bromophenyl)methyl]piperazin-1-yl]-2-phenylethanone
CAS 355814-30-1C19H21BrN2O
1-[4-[(2,5-Dimethoxyphenyl)methyl]piperazin-1-yl]-2-phenylethanone chemical structure, C21H26N2O3, CAS 354536-31-5
1-[4-[(2,5-Dimethoxyphenyl)methyl]piperazin-1-yl]-2-phenylethanone
CAS 354536-31-5C21H26N2O3
1-(2,3-Dimethoxybenzyl)-4-(phenylacetyl)piperazine chemical structure, C21H26N2O3, CAS 462095-36-9
1-(2,3-Dimethoxybenzyl)-4-(phenylacetyl)piperazine
CAS 462095-36-9C21H26N2O3
2-Phenyl-1-[4-[(3,4,5-trimethoxyphenyl)methyl]piperazin-1-yl]ethanone chemical structure, C22H28N2O4, CAS 354535-56-1
2-Phenyl-1-[4-[(3,4,5-trimethoxyphenyl)methyl]piperazin-1-yl]ethanone
CAS 354535-56-1C22H28N2O4
1-[4-[(2,4-Dimethoxyphenyl)methyl]piperazin-1-yl]-2-phenylethanone chemical structure, C21H26N2O3, CAS 354535-65-2
1-[4-[(2,4-Dimethoxyphenyl)methyl]piperazin-1-yl]-2-phenylethanone
CAS 354535-65-2C21H26N2O3
1-[4-[(4-Bromophenyl)methyl]piperazin-1-yl]-2-phenylethanone chemical structure, C19H21BrN2O, CAS 355393-09-8
1-[4-[(4-Bromophenyl)methyl]piperazin-1-yl]-2-phenylethanone
CAS 355393-09-8C19H21BrN2O