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Murcko scaffold

Ring system with 3 rings and 23 atoms

179 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
179
With full pages
14
Scaffold SMILES

O=C(Nc1ccccc1)C1CCN(C(=O)c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)C1CCN(C(=O)c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 179 chemicals

N-(2-Fluorophenyl)-1-(4-methylbenzoyl)piperidine-4-carboxamide chemical structure, C20H21FN2O2, CAS 510722-51-7
N-(2-Fluorophenyl)-1-(4-methylbenzoyl)piperidine-4-carboxamide
CAS 510722-51-7C20H21FN2O2
1-Benzoyl-N-(3,4-dimethylphenyl)piperidine-4-carboxamide chemical structure, C21H24N2O2, CAS 591224-70-3
1-Benzoyl-N-(3,4-dimethylphenyl)piperidine-4-carboxamide
CAS 591224-70-3C21H24N2O2
1-(4-Fluorobenzoyl)-N-(3-methylphenyl)piperidine-4-carboxamide chemical structure, C20H21FN2O2, CAS 591226-88-9
1-(4-Fluorobenzoyl)-N-(3-methylphenyl)piperidine-4-carboxamide
CAS 591226-88-9C20H21FN2O2
1-(4-Fluorobenzoyl)-N-(3-fluorophenyl)piperidine-4-carboxamide chemical structure, C19H18F2N2O2, CAS 591226-98-1
1-(4-Fluorobenzoyl)-N-(3-fluorophenyl)piperidine-4-carboxamide
CAS 591226-98-1C19H18F2N2O2
1-Benzoyl-N-(2-ethylphenyl)piperidine-4-carboxamide chemical structure, C21H24N2O2, CAS 508188-22-5
1-Benzoyl-N-(2-ethylphenyl)piperidine-4-carboxamide
CAS 508188-22-5C21H24N2O2
1-Benzoyl-N-(3,5-dimethylphenyl)piperidine-4-carboxamide chemical structure, C21H24N2O2, CAS 508189-07-9
1-Benzoyl-N-(3,5-dimethylphenyl)piperidine-4-carboxamide
CAS 508189-07-9C21H24N2O2
1-(2-Methylbenzoyl)-N-(2-methylphenyl)piperidine-4-carboxamide chemical structure, C21H24N2O2, CAS 433948-89-1
1-(2-Methylbenzoyl)-N-(2-methylphenyl)piperidine-4-carboxamide
CAS 433948-89-1C21H24N2O2
1-(4-Fluorobenzoyl)-N-(2-fluorophenyl)piperidine-4-carboxamide chemical structure, C19H18F2N2O2, CAS 591238-46-9
1-(4-Fluorobenzoyl)-N-(2-fluorophenyl)piperidine-4-carboxamide
CAS 591238-46-9C19H18F2N2O2
1-Benzoyl-N-(4-fluorophenyl)piperidine-4-carboxamide chemical structure, C19H19FN2O2, CAS 591239-06-4
1-Benzoyl-N-(4-fluorophenyl)piperidine-4-carboxamide
CAS 591239-06-4C19H19FN2O2
1-Benzoyl-N-(2-chlorophenyl)piperidine-4-carboxamide chemical structure, C19H19ClN2O2, CAS 591239-13-3
1-Benzoyl-N-(2-chlorophenyl)piperidine-4-carboxamide
CAS 591239-13-3C19H19ClN2O2
1-(4-Fluorobenzoyl)-N-(4-methylphenyl)piperidine-4-carboxamide chemical structure, C20H21FN2O2, CAS 591239-55-3
1-(4-Fluorobenzoyl)-N-(4-methylphenyl)piperidine-4-carboxamide
CAS 591239-55-3C20H21FN2O2
1-(3,4-Dimethoxybenzoyl)-N-(3,4-dimethoxyphenyl)piperidine-4-carboxamide chemical structure, C23H28N2O6, CAS 433942-49-5
1-(3,4-Dimethoxybenzoyl)-N-(3,4-dimethoxyphenyl)piperidine-4-carboxamide
CAS 433942-49-5C23H28N2O6
Methyl 4-({[1-(3,4,5-trimethoxybenzoyl)-4-piperidinyl]carbonyl}amino)benzoate chemical structure, C24H28N2O7, CAS 664352-89-0
Methyl 4-({[1-(3,4,5-trimethoxybenzoyl)-4-piperidinyl]carbonyl}amino)benzoate
CAS 664352-89-0C24H28N2O7
N-(2,4,5-Trichlorophenyl)-1-(3,4,5-trimethoxybenzoyl)piperidine-4-carboxamide chemical structure, C22H23Cl3N2O5, CAS 664352-94-7
N-(2,4,5-Trichlorophenyl)-1-(3,4,5-trimethoxybenzoyl)piperidine-4-carboxamide
CAS 664352-94-7C22H23Cl3N2O5
1-(4-Bromobenzoyl)-N-(4-chloro-2-methylphenyl)piperidine-4-carboxamide chemical structure, C20H20BrClN2O2, CAS 593263-12-8
1-(4-Bromobenzoyl)-N-(4-chloro-2-methylphenyl)piperidine-4-carboxamide
CAS 593263-12-8C20H20BrClN2O2
N-(4-Acetamidophenyl)-1-(4-tert-butylbenzoyl)piperidine-4-carboxamide chemical structure, C25H31N3O3, CAS 593263-43-5
N-(4-Acetamidophenyl)-1-(4-tert-butylbenzoyl)piperidine-4-carboxamide
CAS 593263-43-5C25H31N3O3
1-(2,4-Dichlorobenzoyl)-N-[4-(trifluoromethyl)phenyl]piperidine-4-carboxamide chemical structure, C20H17Cl2F3N2O2, CAS 593263-35-5
1-(2,4-Dichlorobenzoyl)-N-[4-(trifluoromethyl)phenyl]piperidine-4-carboxamide
CAS 593263-35-5C20H17Cl2F3N2O2
N-(2,6-Difluorophenyl)-1-(3,4-dimethoxybenzoyl)-4-piperidinecarboxamide chemical structure, C21H22F2N2O4, CAS 593263-37-7
N-(2,6-Difluorophenyl)-1-(3,4-dimethoxybenzoyl)-4-piperidinecarboxamide
CAS 593263-37-7C21H22F2N2O4
1-(4-tert-Butylbenzoyl)-N-(2,6-difluorophenyl)piperidine-4-carboxamide chemical structure, C23H26F2N2O2, CAS 593263-41-3
1-(4-tert-Butylbenzoyl)-N-(2,6-difluorophenyl)piperidine-4-carboxamide
CAS 593263-41-3C23H26F2N2O2
1-Benzoyl-N-(3-chloro-4-methoxyphenyl)piperidine-4-carboxamide chemical structure, C20H21ClN2O3, CAS 591226-76-5
1-Benzoyl-N-(3-chloro-4-methoxyphenyl)piperidine-4-carboxamide
CAS 591226-76-5C20H21ClN2O3
1-(3,5-Dimethoxybenzoyl)-N-(4-ethylphenyl)piperidine-4-carboxamide chemical structure, C23H28N2O4, CAS 591226-74-3
1-(3,5-Dimethoxybenzoyl)-N-(4-ethylphenyl)piperidine-4-carboxamide
CAS 591226-74-3C23H28N2O4
N-(3,4-Dichlorophenyl)-1-(3,5-dimethoxybenzoyl)piperidine-4-carboxamide chemical structure, C21H22Cl2N2O4, CAS 508187-89-1
N-(3,4-Dichlorophenyl)-1-(3,5-dimethoxybenzoyl)piperidine-4-carboxamide
CAS 508187-89-1C21H22Cl2N2O4
1-Benzoyl-N-(4-ethoxyphenyl)piperidine-4-carboxamide chemical structure, C21H24N2O3, CAS 591224-78-1
1-Benzoyl-N-(4-ethoxyphenyl)piperidine-4-carboxamide
CAS 591224-78-1C21H24N2O3
1-(3,5-Dimethoxybenzoyl)-N-(4-methylphenyl)piperidine-4-carboxamide chemical structure, C22H26N2O4, CAS 508187-54-0
1-(3,5-Dimethoxybenzoyl)-N-(4-methylphenyl)piperidine-4-carboxamide
CAS 508187-54-0C22H26N2O4