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Murcko scaffold

2-(3-Hydroxy-2H-1,4-benzothiazin-2-yl)-N-phenylethanimidic acid scaffold

160 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
160
With full pages
53
Scaffold SMILES

O=C(CC1Sc2ccccc2NC1=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(3-Hydroxy-2H-1,4-benzothiazin-2-yl)-N-phenylethanimidic acid page
Murcko scaffold O=C(CC1Sc2ccccc2NC1=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 160 chemicals

N-[4-(Dimethylamino)phenyl]-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide chemical structure, C19H18F3N3O2S, CAS 301683-25-0
N-[4-(Dimethylamino)phenyl]-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide
CAS 301683-25-0C19H18F3N3O2S
N-[2-(Methylsulfanyl)phenyl]-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide chemical structure, C17H16N2O2S2, CAS 303033-68-3
N-[2-(Methylsulfanyl)phenyl]-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide
CAS 303033-68-3C17H16N2O2S2
N-(4-Iodophenyl)-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide chemical structure, C16H13IN2O2S, CAS 303033-69-4
N-(4-Iodophenyl)-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide
CAS 303033-69-4C16H13IN2O2S
2-[3-Oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C18H12F6N2O2S, CAS 300812-56-0
2-[3-Oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 300812-56-0C18H12F6N2O2S
N-(2-Ethoxyphenyl)-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide chemical structure, C19H17F3N2O3S, CAS 6122-69-6
N-(2-Ethoxyphenyl)-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide
CAS 6122-69-6C19H17F3N2O3S
N-(4-Hydroxyphenyl)-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide chemical structure, C16H14N2O3S, CAS 300812-55-9
N-(4-Hydroxyphenyl)-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide
CAS 300812-55-9C16H14N2O3S
Ethyl 2-({[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetyl}amino)benzoate chemical structure, C20H17F3N2O4S, CAS 308300-10-9
Ethyl 2-({[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetyl}amino)benzoate
CAS 308300-10-9C20H17F3N2O4S
N-(2,4-Dimethoxyphenyl)-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide chemical structure, C18H18N2O4S, CAS 374908-11-9
N-(2,4-Dimethoxyphenyl)-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide
CAS 374908-11-9C18H18N2O4S
N-(4-Methylphenyl)-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide chemical structure, C18H15F3N2O2S, CAS 380471-01-2
N-(4-Methylphenyl)-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide
CAS 380471-01-2C18H15F3N2O2S
N-(2-Methyl-5-nitrophenyl)-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide chemical structure, C18H14F3N3O4S, CAS 329795-69-9
N-(2-Methyl-5-nitrophenyl)-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide
CAS 329795-69-9C18H14F3N3O4S
N-(2-Bromo-4-methylphenyl)-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide chemical structure, C18H14BrF3N2O2S, CAS 308300-11-0
N-(2-Bromo-4-methylphenyl)-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide
CAS 308300-11-0C18H14BrF3N2O2S
N-(4-Ethoxy-2-nitrophenyl)-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide chemical structure, C19H16F3N3O5S, CAS 308300-16-5
N-(4-Ethoxy-2-nitrophenyl)-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide
CAS 308300-16-5C19H16F3N3O5S
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-(3-oxo-4H-1,4-benzothiazin-2-yl)acetamide chemical structure, C17H12ClF3N2O2S, CAS 367908-26-7
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-(3-oxo-4H-1,4-benzothiazin-2-yl)acetamide
CAS 367908-26-7C17H12ClF3N2O2S
N-[2-(Difluoromethoxy)phenyl]-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide chemical structure, C18H13F5N2O3S, CAS 367908-30-3
N-[2-(Difluoromethoxy)phenyl]-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide
CAS 367908-30-3C18H13F5N2O3S
Ethyl 2-[[2-(3-oxo-4H-1,4-benzothiazin-2-yl)acetyl]amino]benzoate chemical structure, C19H18N2O4S, CAS 367908-44-9
Ethyl 2-[[2-(3-oxo-4H-1,4-benzothiazin-2-yl)acetyl]amino]benzoate
CAS 367908-44-9C19H18N2O4S
N-(4-Methyl-2-nitrophenyl)-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide chemical structure, C18H14F3N3O4S, CAS 430448-31-0
N-(4-Methyl-2-nitrophenyl)-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide
CAS 430448-31-0C18H14F3N3O4S
N-(4-Bromophenyl)-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide chemical structure, C17H12BrF3N2O2S, CAS 385786-44-7
N-(4-Bromophenyl)-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide
CAS 385786-44-7C17H12BrF3N2O2S
N-(4-Ethoxy-2-nitrophenyl)-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide chemical structure, C18H17N3O5S, CAS 367908-42-7
N-(4-Ethoxy-2-nitrophenyl)-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide
CAS 367908-42-7C18H17N3O5S
N-[2-(Difluoromethoxy)phenyl]-2-(3-oxo-4H-1,4-benzothiazin-2-yl)acetamide chemical structure, C17H14F2N2O3S, CAS 367908-43-8
N-[2-(Difluoromethoxy)phenyl]-2-(3-oxo-4H-1,4-benzothiazin-2-yl)acetamide
CAS 367908-43-8C17H14F2N2O3S
N-(2-Bromo-4-methylphenyl)-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide chemical structure, C17H15BrN2O2S, CAS 367908-45-0
N-(2-Bromo-4-methylphenyl)-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide
CAS 367908-45-0C17H15BrN2O2S
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide chemical structure, C18H11ClF6N2O2S, CAS 431926-79-3
N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide
CAS 431926-79-3C18H11ClF6N2O2S
N-(3-Nitrophenyl)-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide chemical structure, C17H12F3N3O4S, CAS 431933-43-6
N-(3-Nitrophenyl)-2-[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetamide
CAS 431933-43-6C17H12F3N3O4S
N-(2-Butoxyphenyl)-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide chemical structure, C20H22N2O3S, CAS 431999-04-1
N-(2-Butoxyphenyl)-2-(3-oxo-3,4-dihydro-2H-1,4-benzothiazin-2-yl)acetamide
CAS 431999-04-1C20H22N2O3S
Methyl 4-({[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetyl}amino)benzoate chemical structure, C19H15F3N2O4S, CAS 385787-07-5
Methyl 4-({[3-oxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]acetyl}amino)benzoate
CAS 385787-07-5C19H15F3N2O4S