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Murcko scaffold

Ring system with 2 rings and 12 atoms

135 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
135
With full pages
8
Scaffold SMILES

O=c1ccnc(-n2cccn2)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1ccnc(-n2cccn2)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 135 chemicals

Ethyl 2-(3,5-dimethylpyrazol-1-yl)-6-oxo-1H-pyrimidine-5-carboxylate chemical structure, C12H14N4O3, CAS 91769-34-5
Ethyl 2-(3,5-dimethylpyrazol-1-yl)-6-oxo-1H-pyrimidine-5-carboxylate
CAS 91769-34-5C12H14N4O3
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4,5-dimethyl-6-oxopyrimidin-1(6H)-yl)acetamide chemical structure, C13H17N5O2, CAS 1002218-82-7
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4,5-dimethyl-6-oxopyrimidin-1(6H)-yl)acetamide
CAS 1002218-82-7C13H17N5O2
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4,5-dimethyl-6-oxopyrimidin-1(6H)-yl)-N-propylacetamide chemical structure, C16H23N5O2, CAS 1002429-22-2
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4,5-dimethyl-6-oxopyrimidin-1(6H)-yl)-N-propylacetamide
CAS 1002429-22-2C16H23N5O2
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4,5-dimethyl-6-oxopyrimidin-1(6H)-yl)-N-isopropylacetamide chemical structure, C16H23N5O2, CAS 1002429-33-5
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4,5-dimethyl-6-oxopyrimidin-1(6H)-yl)-N-isopropylacetamide
CAS 1002429-33-5C16H23N5O2
N-Allyl-2-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-4,5-dimethyl-6-oxopyrimidin-1(6H)-yl)acetamide chemical structure, C16H21N5O2, CAS 1002429-69-7
N-Allyl-2-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-4,5-dimethyl-6-oxopyrimidin-1(6H)-yl)acetamide
CAS 1002429-69-7C16H21N5O2
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-oxo-4-propylpyrimidin-1(6H)-yl)acetamide chemical structure, C14H19N5O2, CAS 1002430-22-9
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-oxo-4-propylpyrimidin-1(6H)-yl)acetamide
CAS 1002430-22-9C14H19N5O2
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-oxo-4-propylpyrimidin-1(6H)-yl)-N-methylacetamide chemical structure, C15H21N5O2, CAS 1002043-43-7
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-oxo-4-propylpyrimidin-1(6H)-yl)-N-methylacetamide
CAS 1002043-43-7C15H21N5O2
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-oxo-4-propylpyrimidin-1(6H)-yl)-N-propylacetamide chemical structure, C17H25N5O2, CAS 1002043-56-2
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-oxo-4-propylpyrimidin-1(6H)-yl)-N-propylacetamide
CAS 1002043-56-2C17H25N5O2
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-oxo-4-propylpyrimidin-1(6H)-yl)-N-isopropylacetamide chemical structure, C17H25N5O2, CAS 1002043-63-1
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-oxo-4-propylpyrimidin-1(6H)-yl)-N-isopropylacetamide
CAS 1002043-63-1C17H25N5O2
N-(tert-Butyl)-2-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-oxo-4-propylpyrimidin-1(6H)-yl)acetamide chemical structure, C18H27N5O2, CAS 1002043-66-4
N-(tert-Butyl)-2-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-oxo-4-propylpyrimidin-1(6H)-yl)acetamide
CAS 1002043-66-4C18H27N5O2
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-oxo-4-propylpyrimidin-1(6H)-yl)-N-(2-methoxyethyl)acetamide chemical structure, C17H25N5O3, CAS 1002043-69-7
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-oxo-4-propylpyrimidin-1(6H)-yl)-N-(2-methoxyethyl)acetamide
CAS 1002043-69-7C17H25N5O3
N-Allyl-2-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-oxo-4-propylpyrimidin-1(6H)-yl)acetamide chemical structure, C17H23N5O2, CAS 1002043-84-6
N-Allyl-2-(2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-oxo-4-propylpyrimidin-1(6H)-yl)acetamide
CAS 1002043-84-6C17H23N5O2
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-5-ethyl-4-methyl-6-oxopyrimidin-1(6H)-yl)acetamide chemical structure, C14H19N5O2, CAS 1013806-49-9
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-5-ethyl-4-methyl-6-oxopyrimidin-1(6H)-yl)acetamide
CAS 1013806-49-9C14H19N5O2
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-5-ethyl-4-methyl-6-oxopyrimidin-1(6H)-yl)-N-isopropylacetamide chemical structure, C17H25N5O2, CAS 1013817-33-8
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-5-ethyl-4-methyl-6-oxopyrimidin-1(6H)-yl)-N-isopropylacetamide
CAS 1013817-33-8C17H25N5O2
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4-ethyl-6-oxopyrimidin-1(6H)-yl)-N-methylacetamide chemical structure, C14H19N5O2, CAS 1013806-15-9
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4-ethyl-6-oxopyrimidin-1(6H)-yl)-N-methylacetamide
CAS 1013806-15-9C14H19N5O2
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4-ethyl-6-oxopyrimidin-1(6H)-yl)-N-(2-methoxyethyl)acetamide chemical structure, C16H23N5O3, CAS 1013806-35-3
2-(2-(3,5-Dimethyl-1H-pyrazol-1-yl)-4-ethyl-6-oxopyrimidin-1(6H)-yl)-N-(2-methoxyethyl)acetamide
CAS 1013806-35-3C16H23N5O3
N-(6-Oxo-2-(1H-pyrazol-1-yl)-1,6-dihydropyrimidin-5-yl)heptanamide chemical structure, C14H19N5O2, CAS 1343458-66-1
N-(6-Oxo-2-(1H-pyrazol-1-yl)-1,6-dihydropyrimidin-5-yl)heptanamide
CAS 1343458-66-1C14H19N5O2
4-Hydroxy-2-(4-methyl-1H-pyrazol-1-yl)pyrimidine-5-carboxylic acid chemical structure, C9H8N4O3, CAS 1187993-21-0
4-Hydroxy-2-(4-methyl-1H-pyrazol-1-yl)pyrimidine-5-carboxylic acid
CAS 1187993-21-0C9H8N4O3
N-{[4-Hydroxy-2-(1H-pyrazol-1-yl)pyrimidin-5-yl]carbonyl}-2-methylalanine chemical structure, C12H13N5O4, CAS 1187992-87-5
N-{[4-Hydroxy-2-(1H-pyrazol-1-yl)pyrimidin-5-yl]carbonyl}-2-methylalanine
CAS 1187992-87-5C12H13N5O4
6-Oxo-2-(1H-pyrazol-1-yl)-1,6-dihydropyrimidine-5-carboxylic acid chemical structure, C8H6N4O3, CAS 1187992-96-6
6-Oxo-2-(1H-pyrazol-1-yl)-1,6-dihydropyrimidine-5-carboxylic acid
CAS 1187992-96-6C8H6N4O3
5-Amino-2-(1H-pyrazol-1-yl)pyrimidin-4-ol chemical structure, C7H7N5O, CAS 1343460-33-2
5-Amino-2-(1H-pyrazol-1-yl)pyrimidin-4-ol
CAS 1343460-33-2C7H7N5O
2-(4-Hydroxy-2-(1H-pyrazol-1-yl)pyrimidin-5-yl)acetic acid chemical structure, C9H8N4O3, CAS 1343461-30-2
2-(4-Hydroxy-2-(1H-pyrazol-1-yl)pyrimidin-5-yl)acetic acid
CAS 1343461-30-2C9H8N4O3
tert-Butyl (6-oxo-2-(1H-pyrazol-1-yl)-1,6-dihydropyrimidin-5-yl)carbamate chemical structure, C12H15N5O3, CAS 1343459-47-1
tert-Butyl (6-oxo-2-(1H-pyrazol-1-yl)-1,6-dihydropyrimidin-5-yl)carbamate
CAS 1343459-47-1C12H15N5O3
Ethyl 6-oxo-2-(1H-pyrazol-1-yl)-1,6-dihydropyrimidine-5-carboxylate chemical structure, C10H10N4O3, CAS 1343572-58-6
Ethyl 6-oxo-2-(1H-pyrazol-1-yl)-1,6-dihydropyrimidine-5-carboxylate
CAS 1343572-58-6C10H10N4O3