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Murcko scaffold

Ring system with 2 rings and 13 atoms

114 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
114
With full pages
15
Scaffold SMILES

c1ccc(Sc2ccncn2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(Sc2ccncn2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 114 chemicals

Ethyl 2-(methylsulfanyl)-4-(phenylsulfanyl)-5-pyrimidinecarboxylate chemical structure, C14H14N2O2S2, CAS 15400-47-2
Ethyl 2-(methylsulfanyl)-4-(phenylsulfanyl)-5-pyrimidinecarboxylate
CAS 15400-47-2C14H14N2O2S2
6-(4-Chlorophenyl)sulfanylpyrimidine-2,4-diamine chemical structure, C10H9ClN4S, CAS 18620-80-9
6-(4-Chlorophenyl)sulfanylpyrimidine-2,4-diamine
CAS 18620-80-9C10H9ClN4S
RefChem:357325 chemical structure, C10H6N4O4S, CAS 73768-68-0
RefChem:357325
CAS 73768-68-0C10H6N4O4S
2-sec-Butoxy-6-(3,5-dimethyl-phenylsulfanyl)-pyrimidin-4-ylamine chemical structure, C16H21N3OS, CAS 284681-84-1
2-sec-Butoxy-6-(3,5-dimethyl-phenylsulfanyl)-pyrimidin-4-ylamine
CAS 284681-84-1C16H21N3OS
2-sec-Butoxy-6-m-tolylsulfanyl-pyrimidin-4-ylamine chemical structure, C15H19N3OS, CAS 284681-85-2
2-sec-Butoxy-6-m-tolylsulfanyl-pyrimidin-4-ylamine
CAS 284681-85-2C15H19N3OS
4-Pyrimidinamine, 2-(butylthio)-6-(phenylthio)- chemical structure, C14H17N3S2, CAS 284681-95-4
4-Pyrimidinamine, 2-(butylthio)-6-(phenylthio)-
CAS 284681-95-4C14H17N3S2
2-Methylpyrimidin-4-yl phenyl sulfide chemical structure, C11H10N2S, CAS 924862-31-7
2-Methylpyrimidin-4-yl phenyl sulfide
CAS 924862-31-7C11H10N2S
4-Fluorophenyl 2-(methylsulfanyl)-6-(trifluoromethyl)-4-pyrimidinyl sulfide chemical structure, C12H8F4N2S2, CAS 303988-10-5
4-Fluorophenyl 2-(methylsulfanyl)-6-(trifluoromethyl)-4-pyrimidinyl sulfide
CAS 303988-10-5C12H8F4N2S2
Methyl 4-[(4-methylphenyl)sulfanyl]-6-(trifluoromethyl)-2-pyrimidinyl sulfide chemical structure, C13H11F3N2S2, CAS 303988-36-5
Methyl 4-[(4-methylphenyl)sulfanyl]-6-(trifluoromethyl)-2-pyrimidinyl sulfide
CAS 303988-36-5C13H11F3N2S2
N-{4-[(4-Chlorophenyl)sulfanyl]-5-methoxy-2-pyrimidinyl}-N,N-dimethylamine chemical structure, C13H14ClN3OS, CAS 400082-33-9
N-{4-[(4-Chlorophenyl)sulfanyl]-5-methoxy-2-pyrimidinyl}-N,N-dimethylamine
CAS 400082-33-9C13H14ClN3OS
Ethyl 2-((4-((4-chlorophenyl)sulfanyl)-5-methoxy-2-pyrimidinyl)sulfanyl)acetate chemical structure, C15H15ClN2O3S2, CAS 338423-25-9
Ethyl 2-((4-((4-chlorophenyl)sulfanyl)-5-methoxy-2-pyrimidinyl)sulfanyl)acetate
CAS 338423-25-9C15H15ClN2O3S2
Ethyl 2-((5-methoxy-4-((4-methoxyphenyl)sulfanyl)-2-pyrimidinyl)sulfanyl)acetate chemical structure, C16H18N2O4S2, CAS 338423-26-0
Ethyl 2-((5-methoxy-4-((4-methoxyphenyl)sulfanyl)-2-pyrimidinyl)sulfanyl)acetate
CAS 338423-26-0C16H18N2O4S2
Ethyl 2-((5-methoxy-4-(phenylsulfanyl)-2-pyrimidinyl)sulfanyl)acetate chemical structure, C15H16N2O3S2, CAS 338423-38-4
Ethyl 2-((5-methoxy-4-(phenylsulfanyl)-2-pyrimidinyl)sulfanyl)acetate
CAS 338423-38-4C15H16N2O3S2
Ethyl 2-((4-((2-chlorophenyl)sulfanyl)-5-methoxy-2-pyrimidinyl)sulfanyl)acetate chemical structure, C15H15ClN2O3S2, CAS 338423-48-6
Ethyl 2-((4-((2-chlorophenyl)sulfanyl)-5-methoxy-2-pyrimidinyl)sulfanyl)acetate
CAS 338423-48-6C15H15ClN2O3S2
Ethyl 2-((5-methoxy-4-((3-(trifluoromethyl)phenyl)sulfanyl)-2-pyrimidinyl)sulfanyl)acetate chemical structure, C16H15F3N2O3S2, CAS 338423-49-7
Ethyl 2-((5-methoxy-4-((3-(trifluoromethyl)phenyl)sulfanyl)-2-pyrimidinyl)sulfanyl)acetate
CAS 338423-49-7C16H15F3N2O3S2
{6-[(4-Chlorophenyl)sulfanyl]-2-methyl-4-pyrimidinyl}methyl methyl ether chemical structure, C13H13ClN2OS, CAS 338747-85-6
{6-[(4-Chlorophenyl)sulfanyl]-2-methyl-4-pyrimidinyl}methyl methyl ether
CAS 338747-85-6C13H13ClN2OS
[6-[(4-Chlorophenyl)sulfanyl]-2-(methylsulfanyl)-4-pyrimidinyl]methyl methyl ether chemical structure, C13H13ClN2OS2, CAS 338747-96-9
[6-[(4-Chlorophenyl)sulfanyl]-2-(methylsulfanyl)-4-pyrimidinyl]methyl methyl ether
CAS 338747-96-9C13H13ClN2OS2
4-((4-Chlorophenyl)sulfanyl)-2-(methylsulfanyl)-5-pyrimidinyl methyl ether chemical structure, C12H11ClN2OS2, CAS 338954-61-3
4-((4-Chlorophenyl)sulfanyl)-2-(methylsulfanyl)-5-pyrimidinyl methyl ether
CAS 338954-61-3C12H11ClN2OS2
4-[(4-Bromophenyl)sulfanyl]-5-methoxy-N,N-dimethyl-2-pyrimidinamine chemical structure, C13H14BrN3OS, CAS 400083-95-6
4-[(4-Bromophenyl)sulfanyl]-5-methoxy-N,N-dimethyl-2-pyrimidinamine
CAS 400083-95-6C13H14BrN3OS
N-(5-Methoxy-4-{[3-(trifluoromethyl)phenyl]sulfanyl}-2-pyrimidinyl)-N,N-dimethylamine chemical structure, C14H14F3N3OS, CAS 400083-96-7
N-(5-Methoxy-4-{[3-(trifluoromethyl)phenyl]sulfanyl}-2-pyrimidinyl)-N,N-dimethylamine
CAS 400083-96-7C14H14F3N3OS
5-Methoxy-4-[(4-methoxyphenyl)sulfanyl]-N,N-dimethyl-2-pyrimidinamine chemical structure, C14H17N3O2S, CAS 400083-97-8
5-Methoxy-4-[(4-methoxyphenyl)sulfanyl]-N,N-dimethyl-2-pyrimidinamine
CAS 400083-97-8C14H17N3O2S
N-{5-Methoxy-4-[(4-methylphenyl)sulfanyl]-2-pyrimidinyl}-N,N-dimethylamine chemical structure, C14H17N3OS, CAS 400083-98-9
N-{5-Methoxy-4-[(4-methylphenyl)sulfanyl]-2-pyrimidinyl}-N,N-dimethylamine
CAS 400083-98-9C14H17N3OS
N-{4-[(3-Chlorophenyl)sulfanyl]-5-methoxy-2-pyrimidinyl}-N,N-dimethylamine chemical structure, C13H14ClN3OS, CAS 400083-99-0
N-{4-[(3-Chlorophenyl)sulfanyl]-5-methoxy-2-pyrimidinyl}-N,N-dimethylamine
CAS 400083-99-0C13H14ClN3OS
Methyl 2-(methylsulfanyl)-4-(phenylsulfanyl)-5-pyrimidinyl ether chemical structure, C12H12N2OS2, CAS 338955-59-2
Methyl 2-(methylsulfanyl)-4-(phenylsulfanyl)-5-pyrimidinyl ether
CAS 338955-59-2C12H12N2OS2