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Murcko scaffold

Ring system with 3 rings and 21 atoms

27 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
27
With full pages
3
Scaffold SMILES

c1ccc(CCN2CCN(Cc3ccccc3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold c1ccc(CCN2CCN(Cc3ccccc3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 27 of 27 chemicals

Henan 8204 chemical structure, C25H39Cl4N3O4Si, CAS 102390-96-5
Henan 8204
CAS 102390-96-5C25H39Cl4N3O4Si
2,6-Dichloro-4-(2-(4-((2,3,4-trimethoxyphenyl)methyl)-1-piperazinyl)-1-((trimethylsilyl)oxy)ethyl)benzeneamine chemical structure, C25H37Cl2N3O4Si, CAS 104672-12-0
2,6-Dichloro-4-(2-(4-((2,3,4-trimethoxyphenyl)methyl)-1-piperazinyl)-1-((trimethylsilyl)oxy)ethyl)benzeneamine
CAS 104672-12-0C25H37Cl2N3O4Si
1-Piperazineethanol, alpha-(4-amino-3,5-dichlorophenyl)-4-((2,3,4-trimethoxyphenyl)methyl)- chemical structure, C22H29Cl2N3O4, CAS 104672-11-9
1-Piperazineethanol, alpha-(4-amino-3,5-dichlorophenyl)-4-((2,3,4-trimethoxyphenyl)methyl)-
CAS 104672-11-9C22H29Cl2N3O4
1-Benzyl-4-(1-phenylpropan-2-yl)piperazine--hydrogen chloride (1/2) chemical structure, C20H28Cl2N2, CAS 16018-27-2
1-Benzyl-4-(1-phenylpropan-2-yl)piperazine--hydrogen chloride (1/2)
CAS 16018-27-2C20H28Cl2N2
2-(4-Benzylpiperazin-1-yl)-1-(4-chlorophenyl)ethanol chemical structure, C19H23ClN2O, CAS 6313-07-1
2-(4-Benzylpiperazin-1-yl)-1-(4-chlorophenyl)ethanol
CAS 6313-07-1C19H23ClN2O
Benzoic acid, 3-(2-(4-(phenylmethyl)-1-piperazinyl)ethyl)-, methyl ester chemical structure, C21H26N2O2, CAS 131028-34-7
Benzoic acid, 3-(2-(4-(phenylmethyl)-1-piperazinyl)ethyl)-, methyl ester
CAS 131028-34-7C21H26N2O2
2-(4-Benzylpiperazino)-1-phenyl-1-ethanol chemical structure, C19H24N2O, CAS 41379-43-5
2-(4-Benzylpiperazino)-1-phenyl-1-ethanol
CAS 41379-43-5C19H24N2O
1-Benzyl-4-(2-phenylpropyl)piperazine chemical structure, C20H26N2, CAS 860462-87-9
1-Benzyl-4-(2-phenylpropyl)piperazine
CAS 860462-87-9C20H26N2
2-(4-Benzylpiperazin-1-yl)-1-(4-nitrophenyl)ethanol chemical structure, C19H23N3O3, CAS 378218-90-7
2-(4-Benzylpiperazin-1-yl)-1-(4-nitrophenyl)ethanol
CAS 378218-90-7C19H23N3O3
1-Piperazineethanol, alpha-phenyl-4-((2,3,4-trimethoxyphenyl)methyl)-, dihydrochloride chemical structure, C22H32Cl2N2O4, CAS 64966-23-0
1-Piperazineethanol, alpha-phenyl-4-((2,3,4-trimethoxyphenyl)methyl)-, dihydrochloride
CAS 64966-23-0C22H32Cl2N2O4
1-Piperazineethanol, alpha-(4-fluorophenyl)-4-(phenylmethyl)-, dihydrochloride chemical structure, C19H25Cl2FN2O, CAS 156809-88-0
1-Piperazineethanol, alpha-(4-fluorophenyl)-4-(phenylmethyl)-, dihydrochloride
CAS 156809-88-0C19H25Cl2FN2O
2-(4-Benzyl-1-piperazinyl)-1-(4-fluorophenyl)ethanol chemical structure, C19H23FN2O, CAS 156809-87-9
2-(4-Benzyl-1-piperazinyl)-1-(4-fluorophenyl)ethanol
CAS 156809-87-9C19H23FN2O
2-(4-Benzylpiperazin-1-yl)-1-(4-chlorophenyl)ethan-1-ol--hydrogen chloride (1/2) chemical structure, C19H25Cl3N2O, CAS 156809-90-4
2-(4-Benzylpiperazin-1-yl)-1-(4-chlorophenyl)ethan-1-ol--hydrogen chloride (1/2)
CAS 156809-90-4C19H25Cl3N2O
1-Piperazineethanol, alpha-(4-bromophenyl)-4-(phenylmethyl)-, dihydrochloride chemical structure, C19H25BrCl2N2O, CAS 156809-94-8
1-Piperazineethanol, alpha-(4-bromophenyl)-4-(phenylmethyl)-, dihydrochloride
CAS 156809-94-8C19H25BrCl2N2O
AM-36 chemical structure, C27H39ClN2O2, CAS 199467-52-2
AM-36
CAS 199467-52-2C27H39ClN2O2
1-[2-(3-Fluorophenyl)ethyl]-4-(phenylmethyl)piperazine chemical structure, C19H23FN2, CAS 200204-89-3
1-[2-(3-Fluorophenyl)ethyl]-4-(phenylmethyl)piperazine
CAS 200204-89-3C19H23FN2
4-({4-[2-(4-Bromophenyl)-2-hydroxyethyl]piperazin-1-yl}methyl)-2,6-di-tert-butylphenol chemical structure, C27H39BrN2O2, CAS 199467-60-2
4-({4-[2-(4-Bromophenyl)-2-hydroxyethyl]piperazin-1-yl}methyl)-2,6-di-tert-butylphenol
CAS 199467-60-2C27H39BrN2O2
3-[[4-(2-Phenylethyl)piperazin-1-yl]methyl]benzonitrile chemical structure, C20H23N3, CAS 918479-51-3
3-[[4-(2-Phenylethyl)piperazin-1-yl]methyl]benzonitrile
CAS 918479-51-3C20H23N3
3-{[4-(2-Phenylethyl)piperazin-1-yl]methyl}benzamide chemical structure, C20H25N3O, CAS 918482-04-9
3-{[4-(2-Phenylethyl)piperazin-1-yl]methyl}benzamide
CAS 918482-04-9C20H25N3O
1-Benzyl-4-(4-bromophenethyl)piperazine chemical structure, C19H23BrN2, CAS 178914-46-0
1-Benzyl-4-(4-bromophenethyl)piperazine
CAS 178914-46-0C19H23BrN2
2,6-Di-tert-butyl-4-{4-[2-(4-chloro-phenyl)-2-hydroxy-ethyl]-piperazin-1-ylmethyl}-phenol dihydrochloride chemical structure, C27H41Cl3N2O2, CAS 1246094-77-8
2,6-Di-tert-butyl-4-{4-[2-(4-chloro-phenyl)-2-hydroxy-ethyl]-piperazin-1-ylmethyl}-phenol dihydrochloride
CAS 1246094-77-8C27H41Cl3N2O2
1-[(4,5-Dimethoxy-2-nitrophenyl)methyl]-4-(2-phenylethyl)piperazine chemical structure, C21H27N3O4, CAS 918479-93-3
1-[(4,5-Dimethoxy-2-nitrophenyl)methyl]-4-(2-phenylethyl)piperazine
CAS 918479-93-3C21H27N3O4
1-[(2,6-Dimethylphenyl)methyl]-4-(2-phenylethyl)piperazine chemical structure, C21H28N2, CAS 918482-02-7
1-[(2,6-Dimethylphenyl)methyl]-4-(2-phenylethyl)piperazine
CAS 918482-02-7C21H28N2
1-(2-Phenylethyl)-4-{[3-(trifluoromethoxy)phenyl]methyl}piperazine chemical structure, C20H23F3N2O, CAS 918479-95-5
1-(2-Phenylethyl)-4-{[3-(trifluoromethoxy)phenyl]methyl}piperazine
CAS 918479-95-5C20H23F3N2O