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Murcko scaffold

Ring system with 3 rings and 25 atoms

30 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
30
With full pages
3
Scaffold SMILES

O=C(COc1ccccc1)Nc1ccc(C(=O)Nc2ccccc2)s1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COc1ccccc1)Nc1ccc(C(=O)Nc2ccccc2)s1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 30 of 30 chemicals

Methyl 2-{[2-(4-chlorophenoxy)-2-methylpropanoyl]amino}-4-methyl-5-(2-toluidinocarbonyl)-3-thiophenecarboxylate chemical structure, C25H25ClN2O5S, CAS 438199-66-7
Methyl 2-{[2-(4-chlorophenoxy)-2-methylpropanoyl]amino}-4-methyl-5-(2-toluidinocarbonyl)-3-thiophenecarboxylate
CAS 438199-66-7C25H25ClN2O5S
4-Cyano-N-(2-methoxyphenyl)-3-methyl-5-(2-phenoxyacetamido)thiophene-2-carboxamide chemical structure, C22H19N3O4S, CAS 503864-33-3
4-Cyano-N-(2-methoxyphenyl)-3-methyl-5-(2-phenoxyacetamido)thiophene-2-carboxamide
CAS 503864-33-3C22H19N3O4S
Ethyl 2-[2-(4-chlorophenoxy)acetamido]-4-methyl-5-[(2-methylphenyl)carbamoyl]thiophene-3-carboxylate chemical structure, C24H23ClN2O5S, CAS 312587-55-6
Ethyl 2-[2-(4-chlorophenoxy)acetamido]-4-methyl-5-[(2-methylphenyl)carbamoyl]thiophene-3-carboxylate
CAS 312587-55-6C24H23ClN2O5S
Ethyl 5-[(2-fluorophenyl)carbamoyl]-4-methyl-2-[(phenoxyacetyl)amino]thiophene-3-carboxylate chemical structure, C23H21FN2O5S, CAS 312597-47-0
Ethyl 5-[(2-fluorophenyl)carbamoyl]-4-methyl-2-[(phenoxyacetyl)amino]thiophene-3-carboxylate
CAS 312597-47-0C23H21FN2O5S
Ethyl 5-[(2,4-dimethylphenyl)carbamoyl]-4-methyl-2-[(phenoxyacetyl)amino]thiophene-3-carboxylate chemical structure, C25H26N2O5S, CAS 332905-98-3
Ethyl 5-[(2,4-dimethylphenyl)carbamoyl]-4-methyl-2-[(phenoxyacetyl)amino]thiophene-3-carboxylate
CAS 332905-98-3C25H26N2O5S
Methyl 2-(2-(4-chlorophenoxy)acetamido)-5-((2,4-dimethylphenyl)carbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C24H23ClN2O5S, CAS 332923-64-5
Methyl 2-(2-(4-chlorophenoxy)acetamido)-5-((2,4-dimethylphenyl)carbamoyl)-4-methylthiophene-3-carboxylate
CAS 332923-64-5C24H23ClN2O5S
Methyl 2-(2-(4-chloro-2-methylphenoxy)acetamido)-4-methyl-5-(o-tolylcarbamoyl)thiophene-3-carboxylate chemical structure, C24H23ClN2O5S, CAS 504431-95-2
Methyl 2-(2-(4-chloro-2-methylphenoxy)acetamido)-4-methyl-5-(o-tolylcarbamoyl)thiophene-3-carboxylate
CAS 504431-95-2C24H23ClN2O5S
Methyl 2-(2-(2,4-dichlorophenoxy)acetamido)-5-((4-ethoxyphenyl)carbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C24H22Cl2N2O6S, CAS 505095-40-9
Methyl 2-(2-(2,4-dichlorophenoxy)acetamido)-5-((4-ethoxyphenyl)carbamoyl)-4-methylthiophene-3-carboxylate
CAS 505095-40-9C24H22Cl2N2O6S
Methyl 2-(2-(2,4-dichlorophenoxy)acetamido)-5-((2,4-dimethylphenyl)carbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C24H22Cl2N2O5S, CAS 505095-51-2
Methyl 2-(2-(2,4-dichlorophenoxy)acetamido)-5-((2,4-dimethylphenyl)carbamoyl)-4-methylthiophene-3-carboxylate
CAS 505095-51-2C24H22Cl2N2O5S
Methyl 2-(2-(4-chlorophenoxy)acetamido)-5-((2-ethoxyphenyl)carbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C24H23ClN2O6S, CAS 505095-79-4
Methyl 2-(2-(4-chlorophenoxy)acetamido)-5-((2-ethoxyphenyl)carbamoyl)-4-methylthiophene-3-carboxylate
CAS 505095-79-4C24H23ClN2O6S
Methyl 5-((2,4-dimethylphenyl)carbamoyl)-4-methyl-2-(2-(o-tolyloxy)acetamido)thiophene-3-carboxylate chemical structure, C25H26N2O5S, CAS 335407-88-0
Methyl 5-((2,4-dimethylphenyl)carbamoyl)-4-methyl-2-(2-(o-tolyloxy)acetamido)thiophene-3-carboxylate
CAS 335407-88-0C25H26N2O5S
Methyl 5-((4-ethoxyphenyl)carbamoyl)-4-methyl-2-(2-(o-tolyloxy)acetamido)thiophene-3-carboxylate chemical structure, C25H26N2O6S, CAS 335406-41-2
Methyl 5-((4-ethoxyphenyl)carbamoyl)-4-methyl-2-(2-(o-tolyloxy)acetamido)thiophene-3-carboxylate
CAS 335406-41-2C25H26N2O6S
Methyl 4-methyl-2-(2-(o-tolyloxy)acetamido)-5-((3-(trifluoromethyl)phenyl)carbamoyl)thiophene-3-carboxylate chemical structure, C24H21F3N2O5S, CAS 335406-74-1
Methyl 4-methyl-2-(2-(o-tolyloxy)acetamido)-5-((3-(trifluoromethyl)phenyl)carbamoyl)thiophene-3-carboxylate
CAS 335406-74-1C24H21F3N2O5S
Methyl 2-(2-(2,4-dichlorophenoxy)acetamido)-5-((2-fluorophenyl)carbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C22H17Cl2FN2O5S, CAS 335408-44-1
Methyl 2-(2-(2,4-dichlorophenoxy)acetamido)-5-((2-fluorophenyl)carbamoyl)-4-methylthiophene-3-carboxylate
CAS 335408-44-1C22H17Cl2FN2O5S
Methyl 5-((2-ethoxyphenyl)carbamoyl)-4-methyl-2-(2-phenoxyacetamido)thiophene-3-carboxylate chemical structure, C24H24N2O6S, CAS 335408-52-1
Methyl 5-((2-ethoxyphenyl)carbamoyl)-4-methyl-2-(2-phenoxyacetamido)thiophene-3-carboxylate
CAS 335408-52-1C24H24N2O6S
Methyl 2-(2-(4-chloro-2-methylphenoxy)acetamido)-5-((4-ethoxyphenyl)carbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C25H25ClN2O6S, CAS 505096-47-9
Methyl 2-(2-(4-chloro-2-methylphenoxy)acetamido)-5-((4-ethoxyphenyl)carbamoyl)-4-methylthiophene-3-carboxylate
CAS 505096-47-9C25H25ClN2O6S
Methyl 2-(2-(2,4-dichlorophenoxy)acetamido)-5-((2-ethoxyphenyl)carbamoyl)-4-methylthiophene-3-carboxylate chemical structure, C24H22Cl2N2O6S, CAS 335409-01-3
Methyl 2-(2-(2,4-dichlorophenoxy)acetamido)-5-((2-ethoxyphenyl)carbamoyl)-4-methylthiophene-3-carboxylate
CAS 335409-01-3C24H22Cl2N2O6S
Methyl 5-((4-ethoxyphenyl)carbamoyl)-4-methyl-2-(2-phenoxyacetamido)thiophene-3-carboxylate chemical structure, C24H24N2O6S, CAS 506416-57-5
Methyl 5-((4-ethoxyphenyl)carbamoyl)-4-methyl-2-(2-phenoxyacetamido)thiophene-3-carboxylate
CAS 506416-57-5C24H24N2O6S
Methyl 5-((2-fluorophenyl)carbamoyl)-4-methyl-2-(2-(o-tolyloxy)acetamido)thiophene-3-carboxylate chemical structure, C23H21FN2O5S, CAS 335410-72-5
Methyl 5-((2-fluorophenyl)carbamoyl)-4-methyl-2-(2-(o-tolyloxy)acetamido)thiophene-3-carboxylate
CAS 335410-72-5C23H21FN2O5S
ET 2-(((4-F-Phenoxy)AC)amino)4-ME-5-(2-toluidinocarbonyl)-3-thiophenecarboxylate chemical structure, C24H23FN2O5S, CAS 331454-81-0
ET 2-(((4-F-Phenoxy)AC)amino)4-ME-5-(2-toluidinocarbonyl)-3-thiophenecarboxylate
CAS 331454-81-0C24H23FN2O5S
Ethyl 5-[(2-fluorophenyl)carbamoyl]-4-methyl-2-{[(2-methylphenoxy)acetyl]amino}thiophene-3-carboxylate chemical structure, C24H23FN2O5S, CAS 347351-56-8
Ethyl 5-[(2-fluorophenyl)carbamoyl]-4-methyl-2-{[(2-methylphenoxy)acetyl]amino}thiophene-3-carboxylate
CAS 347351-56-8C24H23FN2O5S
Ethyl 2-[2-(4-methoxyphenoxy)acetamido]-4-methyl-5-(phenylcarbamoyl)thiophene-3-carboxylate chemical structure, C24H24N2O6S, CAS 425630-85-9
Ethyl 2-[2-(4-methoxyphenoxy)acetamido]-4-methyl-5-(phenylcarbamoyl)thiophene-3-carboxylate
CAS 425630-85-9C24H24N2O6S
Ethyl 2-[2-(4-chlorophenoxy)acetamido]-5-[(2-fluorophenyl)carbamoyl]-4-methylthiophene-3-carboxylate chemical structure, C23H20ClFN2O5S, CAS 330957-17-0
Ethyl 2-[2-(4-chlorophenoxy)acetamido]-5-[(2-fluorophenyl)carbamoyl]-4-methylthiophene-3-carboxylate
CAS 330957-17-0C23H20ClFN2O5S
Ethyl 2-(2-(2-fluorophenoxy)acetamido)-4-methyl-5-(phenylcarbamoyl)thiophene-3-carboxylate chemical structure, C23H21FN2O5S, CAS 518350-22-6
Ethyl 2-(2-(2-fluorophenoxy)acetamido)-4-methyl-5-(phenylcarbamoyl)thiophene-3-carboxylate
CAS 518350-22-6C23H21FN2O5S