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Murcko scaffold

Ring system with 3 rings and 24 atoms

317 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
317
With full pages
7
Scaffold SMILES

O=C(CSc1nnc(COc2ccccc2)[nH]1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(COc2ccccc2)[nH]1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 317 chemicals

Methyl 4-(2-{5-[(4-chlorophenoxy)methyl]-4-ethyl-1,2,4-triazol-3-ylthio}acetyl amino)benzoate chemical structure, C21H21ClN4O4S, CAS 724746-54-7
Methyl 4-(2-{5-[(4-chlorophenoxy)methyl]-4-ethyl-1,2,4-triazol-3-ylthio}acetyl amino)benzoate
CAS 724746-54-7C21H21ClN4O4S
Methyl 4-{[({5-[(4-chlorophenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetyl]amino}benzoate chemical structure, C20H19ClN4O4S, CAS 724746-57-0
Methyl 4-{[({5-[(4-chlorophenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetyl]amino}benzoate
CAS 724746-57-0C20H19ClN4O4S
N-(2-Bromo-4,6-difluorophenyl)-2-[[5-[(2,3-dimethylphenoxy)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C20H19BrF2N4O2S, CAS 708998-90-7
N-(2-Bromo-4,6-difluorophenyl)-2-[[5-[(2,3-dimethylphenoxy)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 708998-90-7C20H19BrF2N4O2S
2-[[5-[(2-Ethoxy-4-methylphenoxy)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(3-methylsulfanylphenyl)acetamide chemical structure, C22H26N4O3S2, CAS 5321-67-5
2-[[5-[(2-Ethoxy-4-methylphenoxy)methyl]-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-(3-methylsulfanylphenyl)acetamide
CAS 5321-67-5C22H26N4O3S2
N-(2-Cyanophenyl)-2-[[5-(phenoxymethyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C21H19N5O2S, CAS 540516-66-3
N-(2-Cyanophenyl)-2-[[5-(phenoxymethyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 540516-66-3C21H19N5O2S
2-[[4-Amino-5-(phenoxymethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[2-(trifluoromethyl)phenyl]acetamide chemical structure, C18H16F3N5O2S, CAS 634172-50-2
2-[[4-Amino-5-(phenoxymethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[2-(trifluoromethyl)phenyl]acetamide
CAS 634172-50-2C18H16F3N5O2S
2-({4-Ethyl-5-[(4-methoxyphenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-N-phenylacetamide chemical structure, C20H22N4O3S, CAS 482651-88-7
2-({4-Ethyl-5-[(4-methoxyphenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-N-phenylacetamide
CAS 482651-88-7C20H22N4O3S
N-Mesityl-2-({5-[(4-methoxyphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide chemical structure, C22H26N4O3S, CAS 485339-87-5
N-Mesityl-2-({5-[(4-methoxyphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide
CAS 485339-87-5C22H26N4O3S
2-({5-[(4-Chlorophenoxy)methyl]-4-ethyl-4H-1,2,4-triazol-3-yl}sulfanyl)-N-(4-ethoxyphenyl)acetamide chemical structure, C21H23ClN4O3S, CAS 483285-71-8
2-({5-[(4-Chlorophenoxy)methyl]-4-ethyl-4H-1,2,4-triazol-3-yl}sulfanyl)-N-(4-ethoxyphenyl)acetamide
CAS 483285-71-8C21H23ClN4O3S
2-({4-Allyl-5-[(4-chlorophenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-N-(2,5-dichlorophenyl)acetamide chemical structure, C20H17Cl3N4O2S, CAS 355002-46-9
2-({4-Allyl-5-[(4-chlorophenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-N-(2,5-dichlorophenyl)acetamide
CAS 355002-46-9C20H17Cl3N4O2S
2-({4-Allyl-5-[(4-chlorophenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-N-(4-chlorophenyl)acetamide chemical structure, C20H18Cl2N4O2S, CAS 355003-22-4
2-({4-Allyl-5-[(4-chlorophenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)-N-(4-chlorophenyl)acetamide
CAS 355003-22-4C20H18Cl2N4O2S
N-{3-Nitro-4-methylphenyl}-2-({5-[(4-methoxyphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide chemical structure, C20H21N5O5S, CAS 493024-06-9
N-{3-Nitro-4-methylphenyl}-2-({5-[(4-methoxyphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide
CAS 493024-06-9C20H21N5O5S
2-({5-[(4-Ethylphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)-N-[3-(trifluoromethyl)phenyl]acetamide chemical structure, C21H21F3N4O2S, CAS 662159-10-6
2-({5-[(4-Ethylphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)-N-[3-(trifluoromethyl)phenyl]acetamide
CAS 662159-10-6C21H21F3N4O2S
N-(4-Bromo-2-fluorophenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide chemical structure, C20H20BrFN4O2S, CAS 662159-00-4
N-(4-Bromo-2-fluorophenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide
CAS 662159-00-4C20H20BrFN4O2S
N-(2-Chlorophenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-4-ethyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide chemical structure, C21H23ClN4O2S, CAS 662159-03-7
N-(2-Chlorophenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-4-ethyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide
CAS 662159-03-7C21H23ClN4O2S
N-(2-Chlorophenyl)-2-({5-[(4-ethylphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide chemical structure, C20H21ClN4O2S, CAS 483331-30-2
N-(2-Chlorophenyl)-2-({5-[(4-ethylphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide
CAS 483331-30-2C20H21ClN4O2S
N-(2-Chlorophenyl)-2-({4-ethyl-5-[(4-ethylphenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide chemical structure, C21H23ClN4O2S, CAS 662159-04-8
N-(2-Chlorophenyl)-2-({4-ethyl-5-[(4-ethylphenoxy)methyl]-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide
CAS 662159-04-8C21H23ClN4O2S
2-({5-[(2,6-Dimethylphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)-N-(4-ethoxyphenyl)acetamide chemical structure, C22H26N4O3S, CAS 662158-94-3
2-({5-[(2,6-Dimethylphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)-N-(4-ethoxyphenyl)acetamide
CAS 662158-94-3C22H26N4O3S
N-(3-Chloro-2-methylphenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide chemical structure, C21H23ClN4O2S, CAS 662158-82-9
N-(3-Chloro-2-methylphenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide
CAS 662158-82-9C21H23ClN4O2S
N-(5-Chloro-2-methoxyphenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-4-ethyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide chemical structure, C22H25ClN4O3S, CAS 662158-84-1
N-(5-Chloro-2-methoxyphenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-4-ethyl-4H-1,2,4-triazol-3-yl}sulfanyl)acetamide
CAS 662158-84-1C22H25ClN4O3S
2-({5-[(2,6-Dimethylphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)-N-(2-fluorophenyl)acetamide chemical structure, C20H21FN4O2S, CAS 662158-85-2
2-({5-[(2,6-Dimethylphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}sulfanyl)-N-(2-fluorophenyl)acetamide
CAS 662158-85-2C20H21FN4O2S
N-(2-Fluorophenyl)-2-[[4-methyl-5-[(5-methyl-2-propan-2-ylphenoxy)methyl]-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C22H25FN4O2S, CAS 692771-55-4
N-(2-Fluorophenyl)-2-[[4-methyl-5-[(5-methyl-2-propan-2-ylphenoxy)methyl]-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 692771-55-4C22H25FN4O2S
N-(2-Chlorophenyl)-2-[[4-methyl-5-[(4-propan-2-ylphenoxy)methyl]-1,2,4-triazol-3-yl]sulfanyl]acetamide chemical structure, C21H23ClN4O2S, CAS 713095-87-5
N-(2-Chlorophenyl)-2-[[4-methyl-5-[(4-propan-2-ylphenoxy)methyl]-1,2,4-triazol-3-yl]sulfanyl]acetamide
CAS 713095-87-5C21H23ClN4O2S
2-({5-[(4-Isopropylphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}thio)-N-mesitylacetamide chemical structure, C24H30N4O2S, CAS 723297-11-8
2-({5-[(4-Isopropylphenoxy)methyl]-4-methyl-4H-1,2,4-triazol-3-yl}thio)-N-mesitylacetamide
CAS 723297-11-8C24H30N4O2S