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Murcko scaffold

Ring system with 3 rings and 25 atoms

31 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
31
With full pages
4
Scaffold SMILES

O=C(Cc1csc(NC(=O)c2ccccc2)n1)NCc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Cc1csc(NC(=O)c2ccccc2)n1)NCc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 31 of 31 chemicals

N-(4-(2-((2,6-Difluorobenzyl)amino)-2-oxoethyl)thiazol-2-yl)-4-methoxybenzamide chemical structure, C20H17F2N3O3S, CAS 941898-79-9
N-(4-(2-((2,6-Difluorobenzyl)amino)-2-oxoethyl)thiazol-2-yl)-4-methoxybenzamide
CAS 941898-79-9C20H17F2N3O3S
N-(4-(2-((4-Fluorobenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide chemical structure, C19H16FN3O2S, CAS 946273-24-1
N-(4-(2-((4-Fluorobenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide
CAS 946273-24-1C19H16FN3O2S
N-(4-(2-((4-Fluorobenzyl)amino)-2-oxoethyl)thiazol-2-yl)-4-methoxybenzamide chemical structure, C20H18FN3O3S, CAS 941984-88-9
N-(4-(2-((4-Fluorobenzyl)amino)-2-oxoethyl)thiazol-2-yl)-4-methoxybenzamide
CAS 941984-88-9C20H18FN3O3S
N-(4-(2-((2-Chlorobenzyl)amino)-2-oxoethyl)thiazol-2-yl)-3,4-dimethoxybenzamide chemical structure, C21H20ClN3O4S, CAS 1005294-92-7
N-(4-(2-((2-Chlorobenzyl)amino)-2-oxoethyl)thiazol-2-yl)-3,4-dimethoxybenzamide
CAS 1005294-92-7C21H20ClN3O4S
N-(4-(2-((4-Fluorobenzyl)amino)-2-oxoethyl)thiazol-2-yl)-3,4-dimethoxybenzamide chemical structure, C21H20FN3O4S, CAS 1005308-17-7
N-(4-(2-((4-Fluorobenzyl)amino)-2-oxoethyl)thiazol-2-yl)-3,4-dimethoxybenzamide
CAS 1005308-17-7C21H20FN3O4S
3,4-Dimethoxy-N-(4-(2-((4-methoxybenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide chemical structure, C22H23N3O5S, CAS 1005294-93-8
3,4-Dimethoxy-N-(4-(2-((4-methoxybenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide
CAS 1005294-93-8C22H23N3O5S
3,4-Dimethoxy-N-(4-(2-((2-methoxybenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide chemical structure, C22H23N3O5S, CAS 1005308-18-8
3,4-Dimethoxy-N-(4-(2-((2-methoxybenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide
CAS 1005308-18-8C22H23N3O5S
3,4-Dimethoxy-N-(4-(2-oxo-2-((1-phenylethyl)amino)ethyl)thiazol-2-yl)benzamide chemical structure, C22H23N3O4S, CAS 1005294-95-0
3,4-Dimethoxy-N-(4-(2-oxo-2-((1-phenylethyl)amino)ethyl)thiazol-2-yl)benzamide
CAS 1005294-95-0C22H23N3O4S
N-(4-(2-((2,6-Difluorobenzyl)amino)-2-oxoethyl)thiazol-2-yl)-3,4-dimethoxybenzamide chemical structure, C21H19F2N3O4S, CAS 1005308-39-3
N-(4-(2-((2,6-Difluorobenzyl)amino)-2-oxoethyl)thiazol-2-yl)-3,4-dimethoxybenzamide
CAS 1005308-39-3C21H19F2N3O4S
N-(4-(2-((4-Fluorobenzyl)amino)-2-oxoethyl)thiazol-2-yl)-3,5-dimethoxybenzamide chemical structure, C21H20FN3O4S, CAS 941943-34-6
N-(4-(2-((4-Fluorobenzyl)amino)-2-oxoethyl)thiazol-2-yl)-3,5-dimethoxybenzamide
CAS 941943-34-6C21H20FN3O4S
N-[4-[2-Keto-2-(o-anisylamino)ethyl]thiazol-2-yl]-3,5-dimethoxy-benzamide chemical structure, C22H23N3O5S, CAS 941984-96-9
N-[4-[2-Keto-2-(o-anisylamino)ethyl]thiazol-2-yl]-3,5-dimethoxy-benzamide
CAS 941984-96-9C22H23N3O5S
3,5-Dimethoxy-N-(4-(2-oxo-2-((1-phenylethyl)amino)ethyl)thiazol-2-yl)benzamide chemical structure, C22H23N3O4S, CAS 941947-47-3
3,5-Dimethoxy-N-(4-(2-oxo-2-((1-phenylethyl)amino)ethyl)thiazol-2-yl)benzamide
CAS 941947-47-3C22H23N3O4S
N-(4-(2-((2-Methoxybenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide chemical structure, C20H19N3O3S, CAS 946304-53-6
N-(4-(2-((2-Methoxybenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide
CAS 946304-53-6C20H19N3O3S
N-(4-(2-((4-Methylbenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide chemical structure, C20H19N3O2S, CAS 946357-08-0
N-(4-(2-((4-Methylbenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide
CAS 946357-08-0C20H19N3O2S
N-(4-(2-((2,6-Difluorobenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide chemical structure, C19H15F2N3O2S, CAS 946357-49-9
N-(4-(2-((2,6-Difluorobenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide
CAS 946357-49-9C19H15F2N3O2S
N-(4-(2-(Benzylamino)-2-oxoethyl)thiazol-2-yl)-4-methoxybenzamide chemical structure, C20H19N3O3S, CAS 946305-18-6
N-(4-(2-(Benzylamino)-2-oxoethyl)thiazol-2-yl)-4-methoxybenzamide
CAS 946305-18-6C20H19N3O3S
N-[4-({[(2-Chlorophenyl)methyl]carbamoyl}methyl)-1,3-thiazol-2-yl]-4-methoxybenzamide chemical structure, C20H18ClN3O3S, CAS 946273-95-6
N-[4-({[(2-Chlorophenyl)methyl]carbamoyl}methyl)-1,3-thiazol-2-yl]-4-methoxybenzamide
CAS 946273-95-6C20H18ClN3O3S
4-Methoxy-N-(4-(2-((4-methoxybenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide chemical structure, C21H21N3O4S, CAS 946203-81-2
4-Methoxy-N-(4-(2-((4-methoxybenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide
CAS 946203-81-2C21H21N3O4S
4-Methoxy-N-(4-(2-((2-methoxybenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide chemical structure, C21H21N3O4S, CAS 946357-73-9
4-Methoxy-N-(4-(2-((2-methoxybenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide
CAS 946357-73-9C21H21N3O4S
4-Methoxy-N-(4-(2-((4-methylbenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide chemical structure, C21H21N3O3S, CAS 946305-22-2
4-Methoxy-N-(4-(2-((4-methylbenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide
CAS 946305-22-2C21H21N3O3S
N-(4-(2-((4-Chlorobenzyl)amino)-2-oxoethyl)thiazol-2-yl)-4-methoxybenzamide chemical structure, C20H18ClN3O3S, CAS 946203-85-6
N-(4-(2-((4-Chlorobenzyl)amino)-2-oxoethyl)thiazol-2-yl)-4-methoxybenzamide
CAS 946203-85-6C20H18ClN3O3S
N-{4-[(Benzylcarbamoyl)methyl]-1,3-thiazol-2-yl}-3,5-dimethoxybenzamide chemical structure, C21H21N3O4S, CAS 946358-05-0
N-{4-[(Benzylcarbamoyl)methyl]-1,3-thiazol-2-yl}-3,5-dimethoxybenzamide
CAS 946358-05-0C21H21N3O4S
N-[4-({[(2-Chlorophenyl)methyl]carbamoyl}methyl)-1,3-thiazol-2-yl]-3,5-dimethoxybenzamide chemical structure, C21H20ClN3O4S, CAS 946274-28-8
N-[4-({[(2-Chlorophenyl)methyl]carbamoyl}methyl)-1,3-thiazol-2-yl]-3,5-dimethoxybenzamide
CAS 946274-28-8C21H20ClN3O4S
3,5-Dimethoxy-N-(4-(2-((4-methoxybenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide chemical structure, C22H23N3O5S, CAS 946204-20-2
3,5-Dimethoxy-N-(4-(2-((4-methoxybenzyl)amino)-2-oxoethyl)thiazol-2-yl)benzamide
CAS 946204-20-2C22H23N3O5S