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Murcko scaffold

Ring system with 3 rings and 24 atoms

58 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
58
With full pages
3
Scaffold SMILES

O=C(CSc1nnc(COc2ccccc2)o1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(COc2ccccc2)o1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 58 chemicals

N-(3-Bromo-4-chlorophenyl)-2-({5-[(2-chlorophenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide chemical structure, C17H12BrCl2N3O3S, CAS 496796-23-7
N-(3-Bromo-4-chlorophenyl)-2-({5-[(2-chlorophenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide
CAS 496796-23-7C17H12BrCl2N3O3S
N-(4-Bromophenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide chemical structure, C19H18BrN3O3S, CAS 591761-74-9
N-(4-Bromophenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide
CAS 591761-74-9C19H18BrN3O3S
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-({5-[(4-ethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide chemical structure, C20H17ClF3N3O3S, CAS 539813-30-4
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-({5-[(4-ethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide
CAS 539813-30-4C20H17ClF3N3O3S
N-(2,4-Dichlorophenyl)-2-({5-[(4-ethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide chemical structure, C19H17Cl2N3O3S, CAS 662158-92-1
N-(2,4-Dichlorophenyl)-2-({5-[(4-ethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide
CAS 662158-92-1C19H17Cl2N3O3S
N-(2,5-Dichlorophenyl)-2-({5-[(4-ethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide chemical structure, C19H17Cl2N3O3S, CAS 662158-93-2
N-(2,5-Dichlorophenyl)-2-({5-[(4-ethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide
CAS 662158-93-2C19H17Cl2N3O3S
N-(4-Bromo-2,3-dimethylphenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide chemical structure, C21H22BrN3O3S, CAS 694463-14-4
N-(4-Bromo-2,3-dimethylphenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide
CAS 694463-14-4C21H22BrN3O3S
N-(4-Chlorophenyl)-2-[[5-[(4-propan-2-ylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide chemical structure, C20H20ClN3O3S, CAS 484020-59-9
N-(4-Chlorophenyl)-2-[[5-[(4-propan-2-ylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
CAS 484020-59-9C20H20ClN3O3S
N-(2-Ethylphenyl)-2-({5-[(4-methylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide chemical structure, C20H21N3O3S, CAS 432004-14-3
N-(2-Ethylphenyl)-2-({5-[(4-methylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide
CAS 432004-14-3C20H21N3O3S
N-(2-Chlorophenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide chemical structure, C19H18ClN3O3S, CAS 713097-04-2
N-(2-Chlorophenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide
CAS 713097-04-2C19H18ClN3O3S
2-[[5-[(3-Methylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2,4,5-trichlorophenyl)acetamide chemical structure, C18H14Cl3N3O3S, CAS 694469-32-4
2-[[5-[(3-Methylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2,4,5-trichlorophenyl)acetamide
CAS 694469-32-4C18H14Cl3N3O3S
N-(4-Bromo-2-propan-2-ylphenyl)-2-[[5-[(4-propan-2-ylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide chemical structure, C23H26BrN3O3S, CAS 713095-88-6
N-(4-Bromo-2-propan-2-ylphenyl)-2-[[5-[(4-propan-2-ylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
CAS 713095-88-6C23H26BrN3O3S
N-(4-Bromo-3-methylphenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide chemical structure, C20H20BrN3O3S, CAS 532388-04-8
N-(4-Bromo-3-methylphenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide
CAS 532388-04-8C20H20BrN3O3S
Methyl 4-{[({5-[(2,6-dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetyl]amino}benzoate chemical structure, C21H21N3O5S, CAS 591764-11-3
Methyl 4-{[({5-[(2,6-dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetyl]amino}benzoate
CAS 591764-11-3C21H21N3O5S
2-({5-[(2,6-Dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)-N-(2-ethylphenyl)acetamide chemical structure, C21H23N3O3S, CAS 591761-72-7
2-({5-[(2,6-Dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)-N-(2-ethylphenyl)acetamide
CAS 591761-72-7C21H23N3O3S
N-(2,5-Dichlorophenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide chemical structure, C19H17Cl2N3O3S, CAS 591761-73-8
N-(2,5-Dichlorophenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide
CAS 591761-73-8C19H17Cl2N3O3S
N-(4-Bromo-2-propan-2-ylphenyl)-2-[[5-[(2,6-dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide chemical structure, C22H24BrN3O3S, CAS 694457-76-6
N-(4-Bromo-2-propan-2-ylphenyl)-2-[[5-[(2,6-dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
CAS 694457-76-6C22H24BrN3O3S
2-({5-[(2,6-Dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)-N-(3,4-dimethylphenyl)acetamide chemical structure, C21H23N3O3S, CAS 591763-70-1
2-({5-[(2,6-Dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)-N-(3,4-dimethylphenyl)acetamide
CAS 591763-70-1C21H23N3O3S
N-(2,4-Dichlorophenyl)-2-[[5-[(2,6-dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide chemical structure, C19H17Cl2N3O3S, CAS 591764-97-5
N-(2,4-Dichlorophenyl)-2-[[5-[(2,6-dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
CAS 591764-97-5C19H17Cl2N3O3S
2-({5-[(2,6-Dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)-N-(2-methyl-5-nitrophenyl)acetamide chemical structure, C20H20N4O5S, CAS 591763-68-7
2-({5-[(2,6-Dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)-N-(2-methyl-5-nitrophenyl)acetamide
CAS 591763-68-7C20H20N4O5S
N-(3-Chloro-2-methylphenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide chemical structure, C20H20ClN3O3S, CAS 591764-98-6
N-(3-Chloro-2-methylphenyl)-2-({5-[(2,6-dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl}sulfanyl)acetamide
CAS 591764-98-6C20H20ClN3O3S
2-[[5-[(2,6-Dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-fluorophenyl)acetamide chemical structure, C19H18FN3O3S, CAS 591764-10-2
2-[[5-[(2,6-Dimethylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-fluorophenyl)acetamide
CAS 591764-10-2C19H18FN3O3S
N-(4-Iodo-2-methylphenyl)-2-[[5-[(4-propan-2-ylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide chemical structure, C21H22IN3O3S, CAS 693230-98-7
N-(4-Iodo-2-methylphenyl)-2-[[5-[(4-propan-2-ylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
CAS 693230-98-7C21H22IN3O3S
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[[5-[(4-propan-2-ylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide chemical structure, C21H19ClF3N3O3S, CAS 693233-61-3
N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[[5-[(4-propan-2-ylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
CAS 693233-61-3C21H19ClF3N3O3S
N-(4-Bromo-2,6-dimethylphenyl)-2-[[5-[(4-propan-2-ylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide chemical structure, C22H24BrN3O3S, CAS 693233-85-1
N-(4-Bromo-2,6-dimethylphenyl)-2-[[5-[(4-propan-2-ylphenoxy)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
CAS 693233-85-1C22H24BrN3O3S