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Murcko scaffold

Ring system with 3 rings and 24 atoms

72 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
72
With full pages
42
Scaffold SMILES

O=C(CSc1nnc(SCc2ccccc2)s1)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(SCc2ccccc2)s1)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 72 chemicals

2-{[5-(Benzylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N-(4-ethoxyphenyl)acetamide chemical structure, C19H19N3O2S3, CAS 499102-30-6
2-{[5-(Benzylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N-(4-ethoxyphenyl)acetamide
CAS 499102-30-6C19H19N3O2S3
2-{[5-(Benzylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N-(2-fluorophenyl)acetamide chemical structure, C17H14FN3OS3, CAS 613227-65-9
2-{[5-(Benzylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N-(2-fluorophenyl)acetamide
CAS 613227-65-9C17H14FN3OS3
2-{[5-(Benzylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N-(3-methoxyphenyl)acetamide chemical structure, C18H17N3O2S3, CAS 613227-66-0
2-{[5-(Benzylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N-(3-methoxyphenyl)acetamide
CAS 613227-66-0C18H17N3O2S3
2-{[5-(Benzylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N-(4-methoxyphenyl)acetamide chemical structure, C18H17N3O2S3, CAS 499102-29-3
2-{[5-(Benzylsulfanyl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N-(4-methoxyphenyl)acetamide
CAS 499102-29-3C18H17N3O2S3
2-({5-[(4-Chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N-(4-methylphenyl)acetamide chemical structure, C18H16ClN3OS3, CAS 499101-87-0
2-({5-[(4-Chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N-(4-methylphenyl)acetamide
CAS 499101-87-0C18H16ClN3OS3
N-(4-Bromo-2-methylphenyl)-2-((5-((4-methoxybenzyl)sulfanyl)-1,3,4-thiadiazol-2-yl)sulfanyl)acetamide chemical structure, C19H18BrN3O2S3, CAS 477313-73-8
N-(4-Bromo-2-methylphenyl)-2-((5-((4-methoxybenzyl)sulfanyl)-1,3,4-thiadiazol-2-yl)sulfanyl)acetamide
CAS 477313-73-8C19H18BrN3O2S3
N-(3-Fluorophenyl)-2-({5-[(4-methoxybenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide chemical structure, C18H16FN3O2S3, CAS 499103-69-4
N-(3-Fluorophenyl)-2-({5-[(4-methoxybenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide
CAS 499103-69-4C18H16FN3O2S3
N-(4-Chlorophenyl)-2-({5-[(4-methoxybenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide chemical structure, C18H16ClN3O2S3, CAS 499103-79-6
N-(4-Chlorophenyl)-2-({5-[(4-methoxybenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide
CAS 499103-79-6C18H16ClN3O2S3
2-({5-[(4-Chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N-(3-fluorophenyl)acetamide chemical structure, C17H13ClFN3OS3, CAS 499101-80-3
2-({5-[(4-Chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N-(3-fluorophenyl)acetamide
CAS 499101-80-3C17H13ClFN3OS3
N-(4-Ethylphenyl)-2-({5-[(4-methoxybenzyl)sulfanyl]-1,3,4-thiadiazol-2-YL}sulfanyl)acetamide chemical structure, C20H21N3O2S3, CAS 499103-87-6
N-(4-Ethylphenyl)-2-({5-[(4-methoxybenzyl)sulfanyl]-1,3,4-thiadiazol-2-YL}sulfanyl)acetamide
CAS 499103-87-6C20H21N3O2S3
2-((5-(Benzylthio)-1,3,4-thiadiazol-2-yl)thio)-N-mesitylacetamide chemical structure, C20H21N3OS3, CAS 477331-60-5
2-((5-(Benzylthio)-1,3,4-thiadiazol-2-yl)thio)-N-mesitylacetamide
CAS 477331-60-5C20H21N3OS3
2-((5-(Benzylthio)-1,3,4-thiadiazol-2-yl)thio)-N-(3-fluorophenyl)acetamide chemical structure, C17H14FN3OS3, CAS 477331-44-5
2-((5-(Benzylthio)-1,3,4-thiadiazol-2-yl)thio)-N-(3-fluorophenyl)acetamide
CAS 477331-44-5C17H14FN3OS3
2-({5-[(4-Methoxybenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N-(3-methylphenyl)acetamide chemical structure, C19H19N3O2S3, CAS 499103-81-0
2-({5-[(4-Methoxybenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N-(3-methylphenyl)acetamide
CAS 499103-81-0C19H19N3O2S3
N-(2,6-Dimethylphenyl)-2-({5-[(4-methoxybenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide chemical structure, C20H21N3O2S3, CAS 499103-93-4
N-(2,6-Dimethylphenyl)-2-({5-[(4-methoxybenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide
CAS 499103-93-4C20H21N3O2S3
2-({5-[(4-Chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N-(3,4-difluorophenyl)acetamide chemical structure, C17H12ClF2N3OS3, CAS 499101-81-4
2-({5-[(4-Chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N-(3,4-difluorophenyl)acetamide
CAS 499101-81-4C17H12ClF2N3OS3
N-(3-Fluoro-4-methylphenyl)-2-({5-[(4-methoxybenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide chemical structure, C19H18FN3O2S3, CAS 499103-71-8
N-(3-Fluoro-4-methylphenyl)-2-({5-[(4-methoxybenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide
CAS 499103-71-8C19H18FN3O2S3
2-((5-(Benzylthio)-1,3,4-thiadiazol-2-yl)thio)-N-(2-meo-5-methylphenyl)acetamide chemical structure, C19H19N3O2S3, CAS 477333-39-4
2-((5-(Benzylthio)-1,3,4-thiadiazol-2-yl)thio)-N-(2-meo-5-methylphenyl)acetamide
CAS 477333-39-4C19H19N3O2S3
N-(3-Chloro-4-methylphenyl)-2-({5-[(4-methoxybenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide chemical structure, C19H18ClN3O2S3, CAS 499103-97-8
N-(3-Chloro-4-methylphenyl)-2-({5-[(4-methoxybenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetamide
CAS 499103-97-8C19H18ClN3O2S3
2-({5-[(4-Methoxybenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N-(2,4,6-trimethylphenyl)acetamide chemical structure, C21H23N3O2S3, CAS 499103-94-5
2-({5-[(4-Methoxybenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N-(2,4,6-trimethylphenyl)acetamide
CAS 499103-94-5C21H23N3O2S3
2-((5-((4-Methoxybenzyl)thio)-1,3,4-thiadiazol-2-yl)thio)-N-(3-(trifluoromethyl)phenyl)acetamide chemical structure, C19H16F3N3O2S3, CAS 499103-76-3
2-((5-((4-Methoxybenzyl)thio)-1,3,4-thiadiazol-2-yl)thio)-N-(3-(trifluoromethyl)phenyl)acetamide
CAS 499103-76-3C19H16F3N3O2S3
2-({5-[(4-Chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N-(2-methoxy-5-methylphenyl)acetamide chemical structure, C19H18ClN3O2S3, CAS 499101-73-4
2-({5-[(4-Chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N-(2-methoxy-5-methylphenyl)acetamide
CAS 499101-73-4C19H18ClN3O2S3
N-(2-Ethoxyphenyl)-2-((5-((4-F-benzyl)thio)-1,3,4-thiadiazol-2-yl)thio)acetamide chemical structure, C19H18FN3O2S3, CAS 477329-04-7
N-(2-Ethoxyphenyl)-2-((5-((4-F-benzyl)thio)-1,3,4-thiadiazol-2-yl)thio)acetamide
CAS 477329-04-7C19H18FN3O2S3
2-((5-(Benzylthio)-1,3,4-thiadiazol-2-yl)thio)-N-(4-(dimethylamino)PH)acetamide chemical structure, C19H20N4OS3, CAS 477333-55-4
2-((5-(Benzylthio)-1,3,4-thiadiazol-2-yl)thio)-N-(4-(dimethylamino)PH)acetamide
CAS 477333-55-4C19H20N4OS3
2-((5-(Benzylthio)-1,3,4-thiadiazol-2-yl)thio)-N-(3-chlorophenyl)acetamide chemical structure, C17H14ClN3OS3, CAS 477331-45-6
2-((5-(Benzylthio)-1,3,4-thiadiazol-2-yl)thio)-N-(3-chlorophenyl)acetamide
CAS 477331-45-6C17H14ClN3OS3