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Murcko scaffold

5-Phenyl-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one scaffold

50 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
50
With full pages
8
Scaffold SMILES

O=C1CNC(c2ccccc2)c2ccccc2N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 5-Phenyl-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one page
Murcko scaffold O=C1CNC(c2ccccc2)c2ccccc2N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 50 chemicals

1-Demethyl-4,5-dihydrodiazepam chemical structure, C15H13ClN2O, CAS 1824-69-7
1-Demethyl-4,5-dihydrodiazepam
CAS 1824-69-7C15H13ClN2O
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-, dihydrochloride chemical structure, C21H27Cl3FN3O, CAS 1972-74-3
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-, dihydrochloride
CAS 1972-74-3C21H27Cl3FN3O
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-7-chloro-1-(3-(dimethylamino)propyl)-5-(o-fluorophenyl)-, dihydrochloride chemical structure, C20H25Cl3FN3O, CAS 4084-16-6
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-7-chloro-1-(3-(dimethylamino)propyl)-5-(o-fluorophenyl)-, dihydrochloride
CAS 4084-16-6C20H25Cl3FN3O
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-7-chloro-1-(3-(diethylamino)propyl)-5-(o-fluorophenyl)-, dihydrochloride chemical structure, C22H29Cl3FN3O, CAS 4084-17-7
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-7-chloro-1-(3-(diethylamino)propyl)-5-(o-fluorophenyl)-, dihydrochloride
CAS 4084-17-7C22H29Cl3FN3O
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-7-chloro-5-(o-fluorophenyl)-1-(3-(methylamino)propyl)-, dihydrochloride, hydrate chemical structure, C19H23Cl3FN3O, CAS 4191-05-3
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-7-chloro-5-(o-fluorophenyl)-1-(3-(methylamino)propyl)-, dihydrochloride, hydrate
CAS 4191-05-3C19H23Cl3FN3O
Uxepam chemical structure, C17H16ClN3O2, CAS 59009-93-7
Uxepam
CAS 59009-93-7C17H16ClN3O2
7-Methyl-5-phenyl-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one chemical structure, C16H16N2O, CAS 17972-75-7
7-Methyl-5-phenyl-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one
CAS 17972-75-7C16H16N2O
2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3,4,5-tetrahydro-5-phenyl-, (S)- chemical structure, C15H13ClN2O, CAS 168753-13-7
2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3,4,5-tetrahydro-5-phenyl-, (S)-
CAS 168753-13-7C15H13ClN2O
2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3,4,5-tetrahydro-5-phenyl-, (R)- chemical structure, C15H13ClN2O, CAS 168753-10-4
2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3,4,5-tetrahydro-5-phenyl-, (R)-
CAS 168753-10-4C15H13ClN2O
(R,S)-1,3,4,5-Tetrahydro-5-phenyl-2H-1,4-benzodiazepin-2-one hydrochloride chemical structure, C15H15ClN2O, CAS 268209-92-3
(R,S)-1,3,4,5-Tetrahydro-5-phenyl-2H-1,4-benzodiazepin-2-one hydrochloride
CAS 268209-92-3C15H15ClN2O
5-Phenyl-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one chemical structure, C15H14N2O, CAS 4177-79-1
5-Phenyl-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one
CAS 4177-79-1C15H14N2O
7-Bromo-5-phenyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-2-one chemical structure, C15H13BrN2O, CAS 17972-72-4
7-Bromo-5-phenyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-2-one
CAS 17972-72-4C15H13BrN2O
7-Bromo-5-(4-fluorophenyl)-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one chemical structure, C15H12BrFN2O, CAS 887201-54-9
7-Bromo-5-(4-fluorophenyl)-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one
CAS 887201-54-9C15H12BrFN2O
7-Bromo-5-(2-chlorophenyl)-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one chemical structure, C15H12BrClN2O, CAS 89445-67-0
7-Bromo-5-(2-chlorophenyl)-1,3,4,5-tetrahydro-1,4-benzodiazepin-2-one
CAS 89445-67-0C15H12BrClN2O
Ethyl 7-bromo-2-oxo-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepine-4-carboxylate chemical structure, C18H17BrN2O3, CAS 313650-44-1
Ethyl 7-bromo-2-oxo-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepine-4-carboxylate
CAS 313650-44-1C18H17BrN2O3
7-Bromo-5-phenyl-4-propionyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one chemical structure, C18H17BrN2O2, CAS 5647-75-6
7-Bromo-5-phenyl-4-propionyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one
CAS 5647-75-6C18H17BrN2O2
4-Acetyl-7-bromo-5-phenyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one chemical structure, C17H15BrN2O2, CAS 312758-72-8
4-Acetyl-7-bromo-5-phenyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one
CAS 312758-72-8C17H15BrN2O2
4-Acetyl-7-bromo-5-(2-chlorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one chemical structure, C17H14BrClN2O2, CAS 312758-73-9
4-Acetyl-7-bromo-5-(2-chlorophenyl)-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 312758-73-9C17H14BrClN2O2
7-Methyl-5-phenyl-4-propionyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one chemical structure, C19H20N2O2, CAS 313683-98-6
7-Methyl-5-phenyl-4-propionyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS 313683-98-6C19H20N2O2
4-Acetyl-7-methyl-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one chemical structure, C18H18N2O2, CAS 312758-75-1
4-Acetyl-7-methyl-5-phenyl-3,5-dihydro-1H-1,4-benzodiazepin-2-one
CAS 312758-75-1C18H18N2O2
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4,7-dinitro-5-methoxy-5-phenyl- chemical structure, C16H14N4O6, CAS 62159-86-8
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4,7-dinitro-5-methoxy-5-phenyl-
CAS 62159-86-8C16H14N4O6
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-7-chloro-5-methoxy-4-nitro-5-phenyl- chemical structure, C16H14ClN3O4, CAS 62159-89-1
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-7-chloro-5-methoxy-4-nitro-5-phenyl-
CAS 62159-89-1C16H14ClN3O4
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-5-(acetyloxy)-4,7-dinitro-5-phenyl- chemical structure, C17H14N4O7, CAS 62658-10-0
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-5-(acetyloxy)-4,7-dinitro-5-phenyl-
CAS 62658-10-0C17H14N4O7
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-7-chloro-5-methoxy-1-methyl-4-nitro-5-phenyl- chemical structure, C17H16ClN3O4, CAS 62658-13-3
2H-1,4-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-7-chloro-5-methoxy-1-methyl-4-nitro-5-phenyl-
CAS 62658-13-3C17H16ClN3O4