Murcko scaffold
Ring system with 2 rings and 14 atoms
75 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 14
- Chemicals
- 75
- With full pages
- 6
Scaffold SMILES
N=C1NC(=O)C(=Cc2ccccc2)S1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 75 chemicals
![5-Bromo-2-ethoxy-4-{[3-methyl-2-(methylimino)-4-oxo-1,3-thiazolidin-5-ylidene]methyl}phenyl acetate chemical structure, C16H17BrN2O4S, CAS 328963-61-7](/s/KSBWQSQABTVFGA-NIXVDPBXSA-N.svg)
5-Bromo-2-ethoxy-4-{[3-methyl-2-(methylimino)-4-oxo-1,3-thiazolidin-5-ylidene]methyl}phenyl acetate
CAS 328963-61-7C16H17BrN2O4S
(2Z,5Z)-3-Ethyl-2-(ethylimino)-5-(3-hydroxybenzylidene)thiazolidin-4-one
CAS 868142-63-6C14H16N2O2S
(2Z,5Z)-3-Ethyl-2-(ethylimino)-5-(4-hydroxybenzylidene)thiazolidin-4-one
CAS 472989-62-1C14H16N2O2S
(2Z,5Z)-5-(2,3-Dimethoxybenzylidene)-3-ethyl-2-(ethylimino)thiazolidin-4-one
CAS 868142-65-8C16H20N2O3S
(2Z,5Z)-5-(2,5-Dimethoxybenzylidene)-3-ethyl-2-(ethylimino)thiazolidin-4-one
CAS 868142-70-5C16H20N2O3S
(2Z,5Z)-5-(4-Ethoxy-3-methoxybenzylidene)-3-ethyl-2-(ethylimino)thiazolidin-4-one
CAS 625410-23-3C17H22N2O3S
Methyl 4-((Z)-((Z)-3-ethyl-2-(ethylimino)-4-oxothiazolidin-5-ylidene)methyl)benzoate
CAS 471919-42-3C16H18N2O3S
![(2Z,5Z)-3-Ethyl-2-(ethylimino)-5-[(4-fluorophenyl)methylidene]-1,3-thiazolidin-4-one chemical structure, C14H15FN2OS, CAS 470675-00-4](/s/DIKUJUZSYCVGBC-JQZIOSGWSA-N.svg)
(2Z,5Z)-3-Ethyl-2-(ethylimino)-5-[(4-fluorophenyl)methylidene]-1,3-thiazolidin-4-one
CAS 470675-00-4C14H15FN2OS
(2Z,5Z)-3-Ethyl-2-(ethylimino)-5-(3,4,5-trimethoxybenzylidene)thiazolidin-4-one
CAS 868142-76-1C17H22N2O4S
(2Z,5Z)-3-Ethyl-2-(ethylimino)-5-(4-hydroxy-3-methoxybenzylidene)thiazolidin-4-one
CAS 352348-02-8C15H18N2O3S
(2Z,5Z)-5-(3-Ethoxy-4-hydroxybenzylidene)-3-ethyl-2-(ethylimino)thiazolidin-4-one
CAS 868142-78-3C16H20N2O3S
(2Z,5Z)-3-Ethyl-2-(ethylimino)-5-(3-nitrobenzylidene)thiazolidin-4-one
CAS 471886-13-2C14H15N3O3S
(2Z,5Z)-3-Ethyl-2-(ethylimino)-5-(4-nitrobenzylidene)thiazolidin-4-one
CAS 469895-42-9C14H15N3O3S
5-(3,4-Dimethoxybenzylidene)-2-imino-3-methylthiazolidin-4-one
CAS 419545-92-9C13H14N2O3S
![5-[(2,3-Dichlorophenyl)methylene]-3-methyl-2-(methylimino)-4-thiazolidinone chemical structure, C12H10Cl2N2OS, CAS 328963-54-8](/s/VVKMSLDIMVIXNW-UHFFFAOYSA-N.svg)
5-[(2,3-Dichlorophenyl)methylene]-3-methyl-2-(methylimino)-4-thiazolidinone
CAS 328963-54-8C12H10Cl2N2OS
(5Z)-5-Benzylidene-3-ethyl-2-ethylimino-1,3-thiazolidin-4-one
CAS 1762-71-6C14H16N2OS
4-((Z)-((Z)-3-Ethyl-2-(ethylimino)-4-oxothiazolidin-5-ylidene)methyl)benzoic acid
CAS 472997-82-3C15H16N2O3S
(2Z,5Z)-3-Ethyl-2-(ethylimino)-5-(2-nitrobenzylidene)thiazolidin-4-one
CAS 868142-80-7C14H15N3O3S
(2E,5E)-2-(Hydroxyimino)-5-(4-nitrobenzylidene)thiazolidin-4-one
CAS 684238-49-1C10H7N3O4S
Rhodanine, 5-(p-methoxybenzylidene)-, 2-oxime
CAS 73855-61-5C11H10N2O3S
2-(Hydroxyamino)-5-(4-(methylthio)benzylidene)thiazol-4(5H)-one
C11H10N2O2S2
![2-{[2-Hydroxy-1-(hydroxymethyl)ethyl]amino}-5-{(E)-[4-(methylsulfanyl)phenyl]methylidene}-1,3-thiazol-4(5H)-one chemical structure, C14H16N2O3S2, CAS 860648-54-0](/s/SQTVMTKFLBDZGX-WUXMJOGZSA-N.svg)
2-{[2-Hydroxy-1-(hydroxymethyl)ethyl]amino}-5-{(E)-[4-(methylsulfanyl)phenyl]methylidene}-1,3-thiazol-4(5H)-one
CAS 860648-54-0C14H16N2O3S2
![2-(Hydroxyamino)-5-{(Z)-[4-(methylsulfanyl)phenyl]methylidene}-1,3-thiazol-4-one chemical structure, C11H10N2O2S2, CAS 860648-64-2](/s/SIDFIPNVMXIWFL-TWGQIWQCSA-N.svg)
2-(Hydroxyamino)-5-{(Z)-[4-(methylsulfanyl)phenyl]methylidene}-1,3-thiazol-4-one
CAS 860648-64-2C11H10N2O2S2
![2-(Hydroxyamino)-5-{(Z)-[2-(trifluoromethyl)phenyl]methylidene}-1,3-thiazol-4-one chemical structure, C11H7F3N2O2S, CAS 866040-89-3](/s/KFFTUJMVVGOZIO-YVMONPNESA-N.svg)
2-(Hydroxyamino)-5-{(Z)-[2-(trifluoromethyl)phenyl]methylidene}-1,3-thiazol-4-one
CAS 866040-89-3C11H7F3N2O2S
- 4-{[4-Oxo-5-{(Z)-[2-(trifluoromethyl)phenyl]methylidene}-1,3-thiazol-2(4H)-yl]amino}butanoic acid866040-88-2C15H13F3N2O3S
- 2-[(5-{(E)-[4-(Methylsulfanyl)phenyl]methylidene}-4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]acetic acid866149-75-9C13H12N2O3S2
- (2E,5Z)-2-Hydroxyimino-5-[(4-methylsulfanylphenyl)methylidene]-1,3-thiazolidin-4-oneC11H10N2O2S2
- 2-Rhodaninone, 5-benzylidene-, 2-oxime74037-15-3C10H8N2O2S
- 2-((E)-((Z)-5-(4-(Dimethylamino)benzylidene)-4-oxothiazolidin-2-ylidene)amino)acetic acid57518-44-2C14H15N3O3S
- (5Z)-2-(Hydroxyamino)-5-{[2-(trifluoromethyl)phenyl]methylidene}-4,5-dihydro-1,3-thiazol-4-oneC11H7F3N2O2S
- N'-(5-Benzylidene-4-oxo-1,3-thiazolidin-2-ylidene)acetohydrazide307975-48-0C12H11N3O2S
- 5-Benzylidene-2-(methylamino)-1,3-thiazol-4(5H)-one36946-78-8C11H10N2OS
- Ethyl 2-[4-[(Z)-(2-imino-4-oxo-1,3-thiazolidin-5-ylidene)methyl]-2-methoxyphenoxy]acetateC15H16N2O5S
- UTA1inh-B1412937-56-5C14H14N2O4S
- (5Z)-2-Hydroxyimino-5-[[2-(trifluoromethyl)phenyl]methylidene]-1,3-thiazolidin-4-oneC11H7F3N2O2S
- (5Z)-2-(Hydroxyamino)-5-{[4-(methylsulfanyl)phenyl]methylidene}-4,5-dihydro-1,3-thiazol-4-oneC11H10N2O2S2
- 2-Amino-5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-4(5H)-thiazolone139226-30-5C18H24N2O2S
- Methyl 4-[(2-imino-4-oxo-1,3-thiazolidin-5-ylidene)methyl]benzoateC12H10N2O3S
- 2-Amino-5-[(4-hydroxy-3-methoxyphenyl)methylidene]-4-thiazolone2489319-28-8C11H10N2O3S
- 2-Amino-5-(3-methoxybenzylidene)thiazol-4(5H)-oneC11H10N2O2S
- Methyl 4-[(Z)-(2-amino-4-oxo-1,3-thiazol-5(4H)-ylidene)methyl]benzoate313226-11-8C12H10N2O3S
- Xanthine oxidase-IN-10851429-65-7C10H8N2OS
- (5Z)-2-Amino-5-[[4-(dimethylamino)phenyl]methylidene]-1,3-thiazol-4-one1198098-01-9C12H13N3OS
- (Z)-2-Amino-5-(3,4-dimethoxybenzylidene)thiazol-4(5H)-one1198098-03-1C12H12N2O3S
- Benzoic acid, 5-[(Z)-(2-amino-4-oxo-5(4H)-thiazolylidene)methyl]-2-hydroxy-1972664-02-0C11H8N2O4S
- 2-Amino-5-(3-methoxy-benzylidene)-thiazol-4-one76979-39-0C11H10N2O2S
- (5Z)-5-[(3-Bromo-4-hydroxy-5-methoxyphenyl)methylidene]-2-imino-1,3-thiazolidin-4-one327030-98-8C11H9BrN2O3S
- (5Z)-5-[(2-Bromo-5-methoxyphenyl)methylidene]-2-imino-1,3-thiazolidin-4-one353768-99-7C11H9BrN2O2S
Related scaffolds
Same ring framework with different atoms or bond orders
c1ccc(Cn2cccn2)cc1271 chemicals
c1ccc(CN2CCCC2)cc1172 chemicals
O=S(=O)(c1ccccc1)N1CCCC1146 chemicals
c1ccc(Cn2ccnc2)cc1107 chemicals![Scaffold c1ccc(N=c2[nH]ccs2)cc1](/scaffold/OGVGQYZRJXSMGC-UHFFFAOYSA-N/structure.svg)
c1ccc(N=c2[nH]ccs2)cc198 chemicals
O=C1NC(=S)SC1=Cc1ccccc186 chemicals
O=C(c1ccccc1)N1CCCC186 chemicals
O=S(=O)(c1ccccc1)n1ccnc184 chemicals![Scaffold O=C(c1ccccc1)c1cc[nH]c1](/scaffold/DSNSKSWTLGZGAN-UHFFFAOYSA-N/structure.svg)
O=C(c1ccccc1)c1cc[nH]c177 chemicals
c1ccc(Cn2ccnn2)cc177 chemicals
c1ccc(Cc2cncs2)cc175 chemicals
c1ccc(Cn2cccc2)cc163 chemicals