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Murcko scaffold

Ring system with 2 rings and 12 atoms

106 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
12
Chemicals
106
With full pages
29
Scaffold SMILES

S=c1sccn1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold S=c1sccn1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 106 chemicals

4-Methyl-3-phenyl-1,3-thiazole-2(3H)-thione chemical structure, C10H9NS2, CAS 5316-80-3
4-Methyl-3-phenyl-1,3-thiazole-2(3H)-thione
CAS 5316-80-3C10H9NS2
3-(4-Methoxyphenyl)-4-methyl-1,3-thiazole-2(3H)-thione chemical structure, C11H11NOS2, CAS 77293-28-8
3-(4-Methoxyphenyl)-4-methyl-1,3-thiazole-2(3H)-thione
CAS 77293-28-8C11H11NOS2
3-(4-Chlorophenyl)-4-methyl-1,3-thiazole-2(3H)-thione chemical structure, C10H8ClNS2, CAS 33682-68-7
3-(4-Chlorophenyl)-4-methyl-1,3-thiazole-2(3H)-thione
CAS 33682-68-7C10H8ClNS2
4-Amino-5-cyano-2,3-dihydro-3-phenyl-2-thioxothiazole chemical structure, C10H7N3S2, CAS 13251-19-9
4-Amino-5-cyano-2,3-dihydro-3-phenyl-2-thioxothiazole
CAS 13251-19-9C10H7N3S2
Ethyl 2-(3-phenyl-2-sulfanylidene-1,3-thiazol-4-yl)acetate chemical structure, C13H13NO2S2, CAS 84645-51-2
Ethyl 2-(3-phenyl-2-sulfanylidene-1,3-thiazol-4-yl)acetate
CAS 84645-51-2C13H13NO2S2
Ethyl 4-amino-3-(2-methoxyphenyl)-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylate chemical structure, C13H14N2O3S2, CAS 312922-29-5
Ethyl 4-amino-3-(2-methoxyphenyl)-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylate
CAS 312922-29-5C13H14N2O3S2
Ethyl 4-amino-3-(2,5-dimethoxyphenyl)-2,3-dihydro-2-thioxo-5-thiazolecarboxylate chemical structure, C14H16N2O4S2, CAS 312922-23-9
Ethyl 4-amino-3-(2,5-dimethoxyphenyl)-2,3-dihydro-2-thioxo-5-thiazolecarboxylate
CAS 312922-23-9C14H16N2O4S2
Ethyl 4-amino-2-thioxo-3-[3-(trifluoromethyl)phenyl]-2,3-dihydro-1,3-thiazole-5-carboxylate chemical structure, C13H11F3N2O2S2, CAS 312922-28-4
Ethyl 4-amino-2-thioxo-3-[3-(trifluoromethyl)phenyl]-2,3-dihydro-1,3-thiazole-5-carboxylate
CAS 312922-28-4C13H11F3N2O2S2
4-Amino-3-(4-methylphenyl)-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxamide chemical structure, C11H11N3OS2, CAS 57037-00-0
4-Amino-3-(4-methylphenyl)-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxamide
CAS 57037-00-0C11H11N3OS2
4-Methyl-3-phenyl-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylic acid chemical structure, C11H9NO2S2, CAS 488733-52-4
4-Methyl-3-phenyl-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylic acid
CAS 488733-52-4C11H9NO2S2
5-Thiazolecarboxamide, 4-amino-2,3-dihydro-3-phenyl-2-thioxo- chemical structure, C10H9N3OS2, CAS 7157-92-8
5-Thiazolecarboxamide, 4-amino-2,3-dihydro-3-phenyl-2-thioxo-
CAS 7157-92-8C10H9N3OS2
Ethyl 4-amino-3-(4-methoxyphenyl)-2-sulfanylidene-1,3-thiazole-5-carboxylate chemical structure, C13H14N2O3S2, CAS 443319-90-2
Ethyl 4-amino-3-(4-methoxyphenyl)-2-sulfanylidene-1,3-thiazole-5-carboxylate
CAS 443319-90-2C13H14N2O3S2
5-Thiazolecarboxylic acid, 4-amino-2,3-dihydro-3-phenyl-2-thioxo-, ethyl ester chemical structure, C12H12N2O2S2, CAS 7202-71-3
5-Thiazolecarboxylic acid, 4-amino-2,3-dihydro-3-phenyl-2-thioxo-, ethyl ester
CAS 7202-71-3C12H12N2O2S2
Ethyl 3-(4-methoxyphenyl)-4-methyl-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylate chemical structure, C14H15NO3S2, CAS 402945-30-6
Ethyl 3-(4-methoxyphenyl)-4-methyl-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylate
CAS 402945-30-6C14H15NO3S2
3-(4-Chlorophenyl)-4-methyl-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylic acid chemical structure, C11H8ClNO2S2, CAS 488804-08-6
3-(4-Chlorophenyl)-4-methyl-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylic acid
CAS 488804-08-6C11H8ClNO2S2
Methyl 4-methyl-3-phenyl-2-thioxo-2,3-dihydrothiazole-5-carboxylate chemical structure, C12H11NO2S2, CAS 429623-36-9
Methyl 4-methyl-3-phenyl-2-thioxo-2,3-dihydrothiazole-5-carboxylate
CAS 429623-36-9C12H11NO2S2
Methyl 3-(4-chlorophenyl)-4-methyl-2-sulfanylidene-1,3-thiazole-5-carboxylate chemical structure, C12H10ClNO2S2, CAS 428827-19-4
Methyl 3-(4-chlorophenyl)-4-methyl-2-sulfanylidene-1,3-thiazole-5-carboxylate
CAS 428827-19-4C12H10ClNO2S2
1-[3-(4-Chlorophenyl)-4-methyl-2-sulfanylidene-1,3-thiazol-5-yl]ethanone chemical structure, C12H10ClNOS2, CAS 692275-96-0
1-[3-(4-Chlorophenyl)-4-methyl-2-sulfanylidene-1,3-thiazol-5-yl]ethanone
CAS 692275-96-0C12H10ClNOS2
4-Amino-3-phenyl-2-thioxo-2,3-dihydro-1,3-thiazole-5-carbothioamide chemical structure, C10H9N3S3, CAS 82013-39-6
4-Amino-3-phenyl-2-thioxo-2,3-dihydro-1,3-thiazole-5-carbothioamide
CAS 82013-39-6C10H9N3S3
Ethyl 4-amino-3-(3-chloro-4-fluorophenyl)-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylate chemical structure, C12H10ClFN2O2S2, CAS 312922-20-6
Ethyl 4-amino-3-(3-chloro-4-fluorophenyl)-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylate
CAS 312922-20-6C12H10ClFN2O2S2
Ethyl 4-amino-3-(2,6-dimethylphenyl)-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylate chemical structure, C14H16N2O2S2, CAS 312922-21-7
Ethyl 4-amino-3-(2,6-dimethylphenyl)-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylate
CAS 312922-21-7C14H16N2O2S2
Ethyl 4-amino-3-(4-chlorophenyl)-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylate chemical structure, C12H11ClN2O2S2, CAS 57037-03-3
Ethyl 4-amino-3-(4-chlorophenyl)-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylate
CAS 57037-03-3C12H11ClN2O2S2
Ethyl 3-(4-chlorophenyl)-4-methyl-2-thioxo-2,3-dihydrothiazole-5-carboxylate chemical structure, C13H12ClNO2S2, CAS 51656-05-4
Ethyl 3-(4-chlorophenyl)-4-methyl-2-thioxo-2,3-dihydrothiazole-5-carboxylate
CAS 51656-05-4C13H12ClNO2S2
4-Amino-3-(4-ethoxyphenyl)-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxamide chemical structure, C12H13N3O2S2, CAS 422302-82-7
4-Amino-3-(4-ethoxyphenyl)-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxamide
CAS 422302-82-7C12H13N3O2S2