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Murcko scaffold

4-(4-Phenylpiperazin-1-yl)-3-(phenylsulfonyl)quinoline scaffold

106 chemicals on CompoundList share this ring system.

Rings: 5
Scaffold atoms: 31
Chemicals: 106
With full pages: 4

Scaffold SMILES

O=S(=O)(c1ccccc1)c1cnc2ccccc2c1N1CCN(c2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 4-(4-Phenylpiperazin-1-yl)-3-(phenylsulfonyl)quinoline page

Murcko scaffold O=S(=O)(c1ccccc1)c1cnc2ccccc2c1N1CCN(c2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 106 chemicals

3-(Benzenesulfonyl)-4-[4-(4-fluorophenyl)piperazin-1-yl]-6,7-dimethoxyquinoline chemical structure, C27H26FN3O4S, CAS 866843-25-6

3-(Benzenesulfonyl)-4-[4-(4-fluorophenyl)piperazin-1-yl]-6,7-dimethoxyquinoline

CAS 866843-25-6C₂₇H₂₆FN₃O₄S

3-(Benzenesulfonyl)-6-ethoxy-4-[4-(4-methoxyphenyl)piperazin-1-yl]quinoline chemical structure, C28H29N3O4S, CAS 866843-29-0

3-(Benzenesulfonyl)-6-ethoxy-4-[4-(4-methoxyphenyl)piperazin-1-yl]quinoline

CAS 866843-29-0C₂₈H₂₉N₃O₄S

6-Fluoro-3-(4-methylphenyl)sulfonyl-4-(4-phenylpiperazin-1-yl)quinoline chemical structure, C26H24FN3O2S, CAS 866846-24-4

6-Fluoro-3-(4-methylphenyl)sulfonyl-4-(4-phenylpiperazin-1-yl)quinoline

CAS 866846-24-4C₂₆H₂₄FN₃O₂S

6-Fluoro-4-(4-(4-fluorophenyl)piperazin-1-yl)-3-tosylquinoline chemical structure, C26H23F2N3O2S, CAS 866846-25-5

6-Fluoro-4-(4-(4-fluorophenyl)piperazin-1-yl)-3-tosylquinoline

CAS 866846-25-5C₂₆H₂₃F₂N₃O₂S

6-Fluoro-4-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(4-methylbenzenesulfonyl)quinoline chemical structure, C27H26FN3O3S, CAS 866846-26-6

6-Fluoro-4-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(4-methylbenzenesulfonyl)quinoline

CAS 866846-26-6C₂₇H₂₆FN₃O₃S

6-Chloro-4-(4-(2-methoxyphenyl)piperazin-1-yl)-3-tosylquinoline chemical structure, C27H26ClN3O3S, CAS 866846-27-7

6-Chloro-4-(4-(2-methoxyphenyl)piperazin-1-yl)-3-tosylquinoline

CAS 866846-27-7C₂₇H₂₆ClN₃O₃S

3-(Benzenesulfonyl)-6-chloro-4-(4-phenylpiperazin-1-yl)quinoline chemical structure, C25H22ClN3O2S, CAS 866812-07-9

3-(Benzenesulfonyl)-6-chloro-4-(4-phenylpiperazin-1-yl)quinoline

CAS 866812-07-9C₂₅H₂₂ClN₃O₂S

3-(Benzenesulfonyl)-6-chloro-4-[4-(4-fluorophenyl)piperazin-1-yl]quinoline chemical structure, C25H21ClFN3O2S, CAS 866812-92-2

3-(Benzenesulfonyl)-6-chloro-4-[4-(4-fluorophenyl)piperazin-1-yl]quinoline

CAS 866812-92-2C₂₅H₂₁ClFN₃O₂S

3-(Benzenesulfonyl)-4-[4-(4-fluorophenyl)piperazin-1-yl]-6-methylquinoline chemical structure, C26H24FN3O2S, CAS 872200-29-8

3-(Benzenesulfonyl)-4-[4-(4-fluorophenyl)piperazin-1-yl]-6-methylquinoline

CAS 872200-29-8C₂₆H₂₄FN₃O₂S

3-(Benzenesulfonyl)-4-[4-(2,3-dimethylphenyl)piperazin-1-yl]-6-methylquinoline chemical structure, C28H29N3O2S, CAS 872200-30-1

3-(Benzenesulfonyl)-4-[4-(2,3-dimethylphenyl)piperazin-1-yl]-6-methylquinoline

CAS 872200-30-1C₂₈H₂₉N₃O₂S

3-(Benzenesulfonyl)-4-[4-(4-fluorophenyl)piperazin-1-yl]quinoline chemical structure, C25H22FN3O2S, CAS 866843-22-3

3-(Benzenesulfonyl)-4-[4-(4-fluorophenyl)piperazin-1-yl]quinoline

CAS 866843-22-3C₂₅H₂₂FN₃O₂S

3-(Benzenesulfonyl)-4-[4-(4-fluorophenyl)piperazin-1-yl]-6-methoxyquinoline chemical structure, C26H24FN3O3S, CAS 866843-23-4

3-(Benzenesulfonyl)-4-[4-(4-fluorophenyl)piperazin-1-yl]-6-methoxyquinoline

CAS 866843-23-4C₂₆H₂₄FN₃O₃S

3-(Benzenesulfonyl)-6-ethoxy-4-[4-(4-fluorophenyl)piperazin-1-yl]quinoline chemical structure, C27H26FN3O3S, CAS 866843-24-5

3-(Benzenesulfonyl)-6-ethoxy-4-[4-(4-fluorophenyl)piperazin-1-yl]quinoline

CAS 866843-24-5C₂₇H₂₆FN₃O₃S

3-(Benzenesulfonyl)-4-[4-(4-methoxyphenyl)piperazin-1-yl]-6-methylquinoline chemical structure, C27H27N3O3S, CAS 866843-27-8

3-(Benzenesulfonyl)-4-[4-(4-methoxyphenyl)piperazin-1-yl]-6-methylquinoline

CAS 866843-27-8C₂₇H₂₇N₃O₃S

3-(Benzenesulfonyl)-4-[4-(2,3-dimethylphenyl)piperazin-1-yl]quinoline chemical structure, C27H27N3O2S, CAS 866843-30-3

3-(Benzenesulfonyl)-4-[4-(2,3-dimethylphenyl)piperazin-1-yl]quinoline

CAS 866843-30-3C₂₇H₂₇N₃O₂S

3-(Benzenesulfonyl)-4-[4-(2,5-dimethylphenyl)piperazin-1-yl]quinoline chemical structure, C27H27N3O2S, CAS 866843-33-6

3-(Benzenesulfonyl)-4-[4-(2,5-dimethylphenyl)piperazin-1-yl]quinoline

CAS 866843-33-6C₂₇H₂₇N₃O₂S

3-(Benzenesulfonyl)-6-fluoro-4-[4-(4-fluorophenyl)piperazin-1-yl]quinoline chemical structure, C25H21F2N3O2S, CAS 866844-29-3

3-(Benzenesulfonyl)-6-fluoro-4-[4-(4-fluorophenyl)piperazin-1-yl]quinoline

CAS 866844-29-3C₂₅H₂₁F₂N₃O₂S

6-Chloro-4-[4-(4-fluorophenyl)piperazin-1-yl]-3-(4-fluorophenyl)sulfonylquinoline chemical structure, C25H20ClF2N3O2S, CAS 866844-30-6

6-Chloro-4-[4-(4-fluorophenyl)piperazin-1-yl]-3-(4-fluorophenyl)sulfonylquinoline

CAS 866844-30-6C₂₅H₂₀ClF₂N₃O₂S

3-(Benzenesulfonyl)-4-[4-(3-chlorophenyl)piperazin-1-yl]quinoline chemical structure, C25H22ClN3O2S, CAS 866844-31-7

3-(Benzenesulfonyl)-4-[4-(3-chlorophenyl)piperazin-1-yl]quinoline

CAS 866844-31-7C₂₅H₂₂ClN₃O₂S

3-(Benzenesulfonyl)-4-[4-(3-chlorophenyl)piperazin-1-yl]-6-methoxyquinoline chemical structure, C26H24ClN3O3S, CAS 866844-32-8

3-(Benzenesulfonyl)-4-[4-(3-chlorophenyl)piperazin-1-yl]-6-methoxyquinoline

CAS 866844-32-8C₂₆H₂₄ClN₃O₃S

3-(Benzenesulfonyl)-4-[4-(2,4-dimethylphenyl)piperazin-1-yl]quinoline chemical structure, C27H27N3O2S, CAS 866844-34-0

3-(Benzenesulfonyl)-4-[4-(2,4-dimethylphenyl)piperazin-1-yl]quinoline

CAS 866844-34-0C₂₇H₂₇N₃O₂S

3-(Benzenesulfonyl)-4-[4-(2,5-dimethylphenyl)piperazin-1-yl]-6-fluoroquinoline chemical structure, C27H26FN3O2S, CAS 866844-35-1

3-(Benzenesulfonyl)-4-[4-(2,5-dimethylphenyl)piperazin-1-yl]-6-fluoroquinoline

CAS 866844-35-1C₂₇H₂₆FN₃O₂S

3-(4-Methylphenyl)sulfonyl-4-(4-phenylpiperazin-1-yl)quinoline chemical structure, C26H25N3O2S, CAS 866847-40-7

3-(4-Methylphenyl)sulfonyl-4-(4-phenylpiperazin-1-yl)quinoline

CAS 866847-40-7C₂₆H₂₅N₃O₂S

6-Methyl-3-(4-methylphenyl)sulfonyl-4-(4-phenylpiperazin-1-yl)quinoline chemical structure, C27H27N3O2S, CAS 866847-41-8

6-Methyl-3-(4-methylphenyl)sulfonyl-4-(4-phenylpiperazin-1-yl)quinoline

CAS 866847-41-8C₂₇H₂₇N₃O₂S