Murcko scaffold
Alpha-BENZYLIDENE-gamma-BUTYROLACTONE scaffold
74 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 13
- Chemicals
- 74
- With full pages
- 7
Scaffold SMILES
O=C1OCCC1=Cc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 74 chemicals
alpha-BENZYLIDENE-gamma-BUTYROLACTONE
C11H10O2
3-(2-Hydroxybenzylidene)dihydrofuran-2(3H)-one
CAS 4736-29-2C11H10O3
4-((2-Oxodihydrofuran-3(2H)-ylidene)methyl)phenyl acetate
C13H12O4
![3-[(3-Hydroxyphenyl)methylidene]oxolan-2-one chemical structure, C11H10O3](/s/YCQYJYIJDKPOTP-UHFFFAOYSA-N.svg)
3-[(3-Hydroxyphenyl)methylidene]oxolan-2-one
C11H10O3
(E)-3-(2-Hydroxybenzylidene)dihydrofuran-2(3H)-one
CAS 58165-18-7C11H10O3
![(3Z)-3-[(2-Hydroxyphenyl)-methylene]-tetrahydro-furan-2-one chemical structure, C11H10O3, CAS 58165-19-8](/s/NAWZWOWKPOCQIM-CLFYSBASSA-N.svg)
(3Z)-3-[(2-Hydroxyphenyl)-methylene]-tetrahydro-furan-2-one
CAS 58165-19-8C11H10O3
3-(4-Methoxy-benzylidene)-dihydro-furan-2-one
CAS 40011-27-6C12H12O3
![3-[(Z)-4-Methoxybenzylidene]oxolane-2-one chemical structure, C12H12O3, CAS 1530-62-7](/s/MBSKMEQHKIKWQZ-NTMALXAHSA-N.svg)
3-[(Z)-4-Methoxybenzylidene]oxolane-2-one
CAS 1530-62-7C12H12O3
3-Benzylidenetetrahydrofuran-2-one
CAS 30959-91-2C11H10O2
(E)-3-Benzylidenedihydrofuran-2(3H)-one
CAS 6285-99-0C11H10O2
![(3E)-3-[(2,5-Dimethoxyphenyl)methylidene]oxolan-2-one chemical structure, C13H14O4, CAS 87084-66-0](/s/RDKLRIGBNMDNDI-VQHVLOKHSA-N.svg)
(3E)-3-[(2,5-Dimethoxyphenyl)methylidene]oxolan-2-one
CAS 87084-66-0C13H14O4
![(3E)-3-[(3,4-Diethoxyphenyl)methylidene]oxolan-2-one chemical structure, C15H18O4, CAS 92582-04-2](/s/GKJMKUJPHWKNEF-FMIVXFBMSA-N.svg)
(3E)-3-[(3,4-Diethoxyphenyl)methylidene]oxolan-2-one
CAS 92582-04-2C15H18O4
3-(3,4-Dichlorobenzylidene)-5-methyldihydrofuran-2(3H)-one
C12H10Cl2O2
![(3E)-3-[(4-Nitrophenyl)methylidene]oxolan-2-one chemical structure, C11H9NO4, CAS 1530-65-0](/s/IYGVSTGAXJZLHE-VQHVLOKHSA-N.svg)
(3E)-3-[(4-Nitrophenyl)methylidene]oxolan-2-one
CAS 1530-65-0C11H9NO4
![(3E)-3-[(5-Acetyl-2-hydroxyphenyl)methylidene]oxolan-2-one chemical structure, C13H12O4, CAS 6322-31-2](/s/ZJZBRSXUNGZMGF-JXMROGBWSA-N.svg)
(3E)-3-[(5-Acetyl-2-hydroxyphenyl)methylidene]oxolan-2-one
CAS 6322-31-2C13H12O4
![(3E)-3-[(4,5-Diethoxy-2-nitrophenyl)methylidene]oxolan-2-one chemical structure, C15H17NO6, CAS 92647-58-0](/s/OBARWZGPUBMWJG-JXMROGBWSA-N.svg)
(3E)-3-[(4,5-Diethoxy-2-nitrophenyl)methylidene]oxolan-2-one
CAS 92647-58-0C15H17NO6
![(3E)-3-[(4-Aminophenyl)methylidene]oxolan-2-one chemical structure, C11H11NO2, CAS 5458-72-0](/s/QHORWUVDDBIDJI-VQHVLOKHSA-N.svg)
(3E)-3-[(4-Aminophenyl)methylidene]oxolan-2-one
CAS 5458-72-0C11H11NO2
![(3E)-3-[(3-Nitrophenyl)methylidene]oxolan-2-one chemical structure, C11H9NO4, CAS 1705-45-9](/s/UCUHWEXTZBUIPQ-RMKNXTFCSA-N.svg)
(3E)-3-[(3-Nitrophenyl)methylidene]oxolan-2-one
CAS 1705-45-9C11H9NO4
2(3H)-Furanone, dihydro-5,5-dimethyl-3-(phenylmethylene)-, (E)-
CAS 101458-39-3C13H14O2
![(3E)-3-[(4-Hydroxy-3-methoxyphenyl)methylidene]oxolan-2-one chemical structure, C12H12O4, CAS 5431-89-0](/s/QEMGCNJJXGZLNC-RMKNXTFCSA-N.svg)
(3E)-3-[(4-Hydroxy-3-methoxyphenyl)methylidene]oxolan-2-one
CAS 5431-89-0C12H12O4
3-(4-Hydroxybenzylidene)dihydro-2(3H)-furanone
CAS 4736-30-5C11H10O3
![(3E)-3-[(3,4,5-Trimethoxyphenyl)methylidene]oxolan-2-one chemical structure, C14H16O5, CAS 1530-58-1](/s/GMQGMAWKJNOEKX-UXBLZVDNSA-N.svg)
(3E)-3-[(3,4,5-Trimethoxyphenyl)methylidene]oxolan-2-one
CAS 1530-58-1C14H16O5
![(3E)-3-[(3-Acetyl-4-hydroxyphenyl)methylidene]oxolan-2-one chemical structure, C13H12O4, CAS 91903-43-4](/s/RSRJFLATPOURPB-UXBLZVDNSA-N.svg)
(3E)-3-[(3-Acetyl-4-hydroxyphenyl)methylidene]oxolan-2-one
CAS 91903-43-4C13H12O4
![(3E)-3-[(4,5-Dimethoxy-2-nitrophenyl)methylidene]oxolan-2-one chemical structure, C13H13NO6, CAS 1530-59-2](/s/VQQQXNNQIYCWKZ-VMPITWQZSA-N.svg)
(3E)-3-[(4,5-Dimethoxy-2-nitrophenyl)methylidene]oxolan-2-one
CAS 1530-59-2C13H13NO6
- 5-Methyl-3-(3,4,5-trimethoxybenzylidene)dihydro-2(3H)-furanone502180-50-9C15H18O5
- (3E)-3-Benzylidene-5-methyloxolan-2-one21441-45-2C12H12O2
- 3-(3,4-Dimethoxybenzylidene)dihydro-2(3H)-furanone5443-11-8C13H14O4
- 3-(4-Methylbenzylidene)dihydro-2(3H)-furanone5418-24-6C12H12O2
- 4-[(E)-(2-Oxooxolan-3-ylidene)methyl]benzonitrile1530-63-8C12H9NO2
- 3-(2-Chlorobenzylidene)dihydrofuran-2(3H)-one5462-00-0C11H9ClO2
- (3E)-3-[(4,5-Diethoxy-2-nitrophenyl)methylidene]-5-methyloxolan-2-one94066-88-3C16H19NO6
- (3Z)-3-[Bromo(phenyl)methylidene]oxolan-2-one7153-56-2C11H9BrO2
- 2(3H)-Furanone, 3-[[4-(acetyloxy)phenyl]methylene]dihydro-91903-44-5C13H12O4
- (3Z)-3-Benzylidene-5,5-dimethyloxolan-2-one66341-25-1C13H14O2
- (3E)-3-[[4-(Diethylamino)phenyl]methylidene]oxolan-2-one5447-23-4C15H19NO2
- 3-(4-(Dimethylamino)benzylidene)dihydro-2(3H)-furanone58557-39-4C13H15NO2
- Kme 483677-24-1C19H26O3
- 3-(3,4-Diethoxybenzylidene)dihydrofuran-2(3H)-oneC15H18O4
- (3E)-3-[(3,4-Dichlorophenyl)methylidene]-5-methyloxolan-2-one93256-69-0C12H10Cl2O2
- (E)-3-(4-Methoxybenzylidene)-5-methyldihydrofuran-2(3H)-one116249-71-9C13H14O3
- [4-[(Z)-(2-Oxooxolan-3-ylidene)methyl]phenyl] acetateC13H12O4
- Avicennone A943723-99-7C17H20O6
- (E)-3-(3,4-Dihydroxybenzylidene)dihydrofuran-2(3H)-one102271-71-6C11H10O4
- 3-(3,4-Dihydroxybenzylidene)dihydrofuran-2(3H)-oneC11H10O4
- 3-(2,3-Dimethoxybenzylidene)dihydrofuran-2(3H)-one91910-57-5C13H14O4
- 3-(3,4-Diethoxybenzylidene)-5-methyldihydrofuran-2(3H)-one93159-61-6C16H20O4
- (3Z)-3-[(3-Hydroxyphenyl)methylidene]oxolan-2-one1570-89-4C11H10O3
- 3-(Bromo(phenyl)methylene)dihydrofuran-2(3H)-oneC11H9BrO2
Related scaffolds
Same ring framework with different atoms or bond orders
c1ccc(Cn2cccn2)cc1271 chemicals
c1ccc(CN2CCCC2)cc1172 chemicals
O=S(=O)(c1ccccc1)N1CCCC1146 chemicals
c1ccc(Cn2ccnc2)cc1107 chemicals![Scaffold c1ccc(N=c2[nH]ccs2)cc1](/scaffold/OGVGQYZRJXSMGC-UHFFFAOYSA-N/structure.svg)
c1ccc(N=c2[nH]ccs2)cc198 chemicals
O=C1NC(=S)SC1=Cc1ccccc186 chemicals
O=C(c1ccccc1)N1CCCC186 chemicals
O=S(=O)(c1ccccc1)n1ccnc184 chemicals![Scaffold O=C(c1ccccc1)c1cc[nH]c1](/scaffold/DSNSKSWTLGZGAN-UHFFFAOYSA-N/structure.svg)
O=C(c1ccccc1)c1cc[nH]c177 chemicals
c1ccc(Cn2ccnn2)cc177 chemicals
c1ccc(Cc2cncs2)cc175 chemicals
c1ccc(Cn2cccc2)cc163 chemicals