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Murcko scaffold

4H-1,3-Benzodioxin scaffold

210 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
10
Chemicals
210
With full pages
19
Scaffold SMILES

c1ccc2c(c1)COCO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4H-1,3-Benzodioxin page
Murcko scaffold c1ccc2c(c1)COCO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 210 chemicals

1,3-Benzodioxan-8-methylamine, 6-chloro-N-(2-(diethylamino)ethyl)- chemical structure, C15H23ClN2O2, CAS 100310-80-3
1,3-Benzodioxan-8-methylamine, 6-chloro-N-(2-(diethylamino)ethyl)-
CAS 100310-80-3C15H23ClN2O2
4H-1,3-Benzodioxin chemical structure, C8H8O2, CAS 254-27-3
4H-1,3-Benzodioxin
CAS 254-27-3C8H8O2
4H-1,3-Benzodioxin-6-carboxaldehyde chemical structure, C9H8O3, CAS 92607-80-2
4H-1,3-Benzodioxin-6-carboxaldehyde
CAS 92607-80-2C9H8O3
1,3-Benzodioxan, 6-amino- chemical structure, C8H9NO2, CAS 22791-64-6
1,3-Benzodioxan, 6-amino-
CAS 22791-64-6C8H9NO2
2,4-Bis(trichloromethyl)-benzo(1,3)dioxin-6-carboxylic acid chemical structure, C11H6Cl6O4, CAS 61720-31-8
2,4-Bis(trichloromethyl)-benzo(1,3)dioxin-6-carboxylic acid
CAS 61720-31-8C11H6Cl6O4
6-Nitro-2,4-bis(trichloromethyl)-4H-1,3-benzodioxine chemical structure, C10H5Cl6NO4, CAS 61719-86-6
6-Nitro-2,4-bis(trichloromethyl)-4H-1,3-benzodioxine
CAS 61719-86-6C10H5Cl6NO4
2,4-Bis(trichloromethyl)-4H-1,3-benzodioxine-6-sulfonic acid chemical structure, C10H6Cl6O5S, CAS 61719-87-7
2,4-Bis(trichloromethyl)-4H-1,3-benzodioxine-6-sulfonic acid
CAS 61719-87-7C10H6Cl6O5S
6,8-Dinitro-2,4-bis(trichloromethyl)-4H-1,3-benzodioxine chemical structure, C10H4Cl6N2O6, CAS 61720-09-0
6,8-Dinitro-2,4-bis(trichloromethyl)-4H-1,3-benzodioxine
CAS 61720-09-0C10H4Cl6N2O6
6,8-Dichloro-4H-1,3-benzodioxine chemical structure, C8H6Cl2O2, CAS 7355-99-9
6,8-Dichloro-4H-1,3-benzodioxine
CAS 7355-99-9C8H6Cl2O2
6-Nitro-1,3-benzodioxane chemical structure, C8H7NO4, CAS 6963-03-7
6-Nitro-1,3-benzodioxane
CAS 6963-03-7C8H7NO4
6,8-Dinitro-4H-1,3-benzodioxine chemical structure, C8H6N2O6, CAS 16607-27-5
6,8-Dinitro-4H-1,3-benzodioxine
CAS 16607-27-5C8H6N2O6
6-Nitro-2,4-dihydro-1,3-benzodioxine-8-carbaldehyde chemical structure, C9H7NO5, CAS 149744-61-6
6-Nitro-2,4-dihydro-1,3-benzodioxine-8-carbaldehyde
CAS 149744-61-6C9H7NO5
6-Bromo-2,2,4,4-tetrafluoro-1,3-benzodioxane chemical structure, C8H3BrF4O2, CAS 261762-36-1
6-Bromo-2,2,4,4-tetrafluoro-1,3-benzodioxane
CAS 261762-36-1C8H3BrF4O2
6-Isocyanato-2,2,4,4-tetrafluoro-1,3-benzodioxane chemical structure, C9H3F4NO3, CAS 26030-46-6
6-Isocyanato-2,2,4,4-tetrafluoro-1,3-benzodioxane
CAS 26030-46-6C9H3F4NO3
2,2,4,4-Tetrafluoro-4H-benzo[d][1,3]dioxin-6-amine chemical structure, C8H5F4NO2, CAS 25854-59-5
2,2,4,4-Tetrafluoro-4H-benzo[d][1,3]dioxin-6-amine
CAS 25854-59-5C8H5F4NO2
6-Chloro-8-(chloromethyl)-2,4-dihydro-1,3-benzodioxine chemical structure, C9H8Cl2O2, CAS 175136-61-5
6-Chloro-8-(chloromethyl)-2,4-dihydro-1,3-benzodioxine
CAS 175136-61-5C9H8Cl2O2
6-Fluoro-4H-1,3-benzodioxine-8-carboxylic acid chemical structure, C9H7FO4, CAS 321309-28-8
6-Fluoro-4H-1,3-benzodioxine-8-carboxylic acid
CAS 321309-28-8C9H7FO4
6-Fluoro-4H-1,3-benzodioxine-8-carbonyl chloride chemical structure, C9H6ClFO3, CAS 321309-29-9
6-Fluoro-4H-1,3-benzodioxine-8-carbonyl chloride
CAS 321309-29-9C9H6ClFO3
6-Fluoro-4H-1,3-benzodioxine-8-carbaldehyde chemical structure, C9H7FO3, CAS 306934-87-2
6-Fluoro-4H-1,3-benzodioxine-8-carbaldehyde
CAS 306934-87-2C9H7FO3
6-Fluoro-8-isocyanato-4H-benzo(1,3)dioxine chemical structure, C9H6FNO3, CAS 321309-30-2
6-Fluoro-8-isocyanato-4H-benzo(1,3)dioxine
CAS 321309-30-2C9H6FNO3
(6-Fluoro-4H-1,3-benzodioxin-8-yl)methanol chemical structure, C9H9FO3, CAS 306934-89-4
(6-Fluoro-4H-1,3-benzodioxin-8-yl)methanol
CAS 306934-89-4C9H9FO3
(6-Fluoro-4H-1,3-benzodioxin-8-yl)methylamine chemical structure, C9H10FNO2, CAS 306934-88-3
(6-Fluoro-4H-1,3-benzodioxin-8-yl)methylamine
CAS 306934-88-3C9H10FNO2
8-Chloromethyl-6-fluoro-4H-benzo(1,3)dioxine chemical structure, C9H8ClFO2, CAS 131728-94-4
8-Chloromethyl-6-fluoro-4H-benzo(1,3)dioxine
CAS 131728-94-4C9H8ClFO2
6-Bromo-8-(chloromethyl)-4H-1,3-benzodioxine chemical structure, C9H8BrClO2, CAS 129888-79-5
6-Bromo-8-(chloromethyl)-4H-1,3-benzodioxine
CAS 129888-79-5C9H8BrClO2