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Murcko scaffold

3,4-Diphenylisoxazole scaffold

96 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
96
With full pages
10
Scaffold SMILES

c1ccc(-c2conc2-c2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3,4-Diphenylisoxazole page
Murcko scaffold c1ccc(-c2conc2-c2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 96 chemicals

Mofezolac chemical structure, C19H17NO5, CAS 78967-07-4
Mofezolac
CAS 78967-07-4C19H17NO5
Valdecoxib chemical structure, C16H14N2O3S, CAS 181695-72-7
Valdecoxib
CAS 181695-72-7C16H14N2O3S
Parecoxib chemical structure, C19H18N2O4S, CAS 198470-84-7
Parecoxib
CAS 198470-84-7C19H18N2O4S
5-Chloro-3,4-diphenyl-1,2-oxazole chemical structure, C15H10ClNO, CAS 63954-98-3
5-Chloro-3,4-diphenyl-1,2-oxazole
CAS 63954-98-3C15H10ClNO
1-(3,4-Diphenyl-1,2-oxazol-5-yl)ethanone chemical structure, C17H13NO2, CAS 1631-96-5
1-(3,4-Diphenyl-1,2-oxazol-5-yl)ethanone
CAS 1631-96-5C17H13NO2
3,4-Diphenylisoxazole chemical structure, C15H11NO, CAS 7467-78-9
3,4-Diphenylisoxazole
CAS 7467-78-9C15H11NO
Diphenyl-1,2-oxazol-5-amine chemical structure, C15H12N2O, CAS 52392-73-1
Diphenyl-1,2-oxazol-5-amine
CAS 52392-73-1C15H12N2O
3,4-Bis(4-methoxyphenyl)-5-methylisoxazole chemical structure, C18H17NO3, CAS 78967-05-2
3,4-Bis(4-methoxyphenyl)-5-methylisoxazole
CAS 78967-05-2C18H17NO3
Isoxazole, 5-methyl-4-[4-(methylsulfonyl)phenyl]-3-phenyl- chemical structure, C17H15NO3S, CAS 181695-76-1
Isoxazole, 5-methyl-4-[4-(methylsulfonyl)phenyl]-3-phenyl-
CAS 181695-76-1C17H15NO3S
1-Hydroxyvaldecoxib chemical structure, C16H14N2O4S, CAS 181695-81-8
1-Hydroxyvaldecoxib
CAS 181695-81-8C16H14N2O4S
2-Fluoro-4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide chemical structure, C16H13FN2O3S, CAS 370874-50-3
2-Fluoro-4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
CAS 370874-50-3C16H13FN2O3S
4-(5-Methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sulfonyl chloride chemical structure, C16H12ClNO3S, CAS 509074-26-4
4-(5-Methyl-3-phenyl-1,2-oxazol-4-yl)benzene-1-sulfonyl chloride
CAS 509074-26-4C16H12ClNO3S
(3-Phenyl-4-(4-sulfamoylphenyl)-1,2-oxazol-5-yl)methyl nitrate chemical structure, C16H13N3O6S, CAS 346683-70-3
(3-Phenyl-4-(4-sulfamoylphenyl)-1,2-oxazol-5-yl)methyl nitrate
CAS 346683-70-3C16H13N3O6S
5-Methyl-3,4-diphenyl-isoxazole chemical structure, C16H13NO, CAS 37928-17-9
5-Methyl-3,4-diphenyl-isoxazole
CAS 37928-17-9C16H13NO
COX-2 Inhibitor II chemical structure, C16H12F2N2O3S, CAS 181696-33-3
COX-2 Inhibitor II
CAS 181696-33-3C16H12F2N2O3S
3,4-Diphenyl-5-ethylisoxazole chemical structure, C17H15NO, CAS 74048-23-0
3,4-Diphenyl-5-ethylisoxazole
CAS 74048-23-0C17H15NO
3-(4-Methylsulfonylphenyl)-4-phenyl-5-trifluoromethylisoxazole chemical structure, C17H12F3NO3S, CAS 340267-36-9
3-(4-Methylsulfonylphenyl)-4-phenyl-5-trifluoromethylisoxazole
CAS 340267-36-9C17H12F3NO3S
N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)butyramide (Palbociclib Impurity) chemical structure, C20H20N2O4S, CAS 198470-91-6
N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)butyramide (Palbociclib Impurity)
CAS 198470-91-6C20H20N2O4S
N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)acetamide chemical structure, C18H16N2O4S, CAS 198471-06-6
N-((4-(5-Methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)acetamide
CAS 198471-06-6C18H16N2O4S
5-Isoxazoleacetic acid, 3,4-bis(4-methoxyphenyl)-, methyl ester chemical structure, C20H19NO5, CAS 131454-49-4
5-Isoxazoleacetic acid, 3,4-bis(4-methoxyphenyl)-, methyl ester
CAS 131454-49-4C20H19NO5
Benzenesulfonamide, N-hydroxy-4-(5-methyl-3-phenyl-4-isoxazolyl)- chemical structure, C16H14N2O4S, CAS 501093-49-8
Benzenesulfonamide, N-hydroxy-4-(5-methyl-3-phenyl-4-isoxazolyl)-
CAS 501093-49-8C16H14N2O4S
2,4,6-Trimethyl-3-(5-methyl-4-phenyl-1,2-oxazol-3-yl)benzenesulfonamide chemical structure, C19H20N2O3S, CAS 775344-85-9
2,4,6-Trimethyl-3-(5-methyl-4-phenyl-1,2-oxazol-3-yl)benzenesulfonamide
CAS 775344-85-9C19H20N2O3S
4-(3-(4-Fluorophenyl)-5-methylisoxazol-4-yl)benzenesulfonamide chemical structure, C16H13FN2O3S, CAS 181696-40-2
4-(3-(4-Fluorophenyl)-5-methylisoxazol-4-yl)benzenesulfonamide
CAS 181696-40-2C16H13FN2O3S
4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonic acid chemical structure, C16H13NO4S, CAS 181696-35-5
4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonic acid
CAS 181696-35-5C16H13NO4S