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Murcko scaffold

Ring system with 3 rings and 20 atoms

91 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 20
Chemicals: 91
With full pages: 6

Scaffold SMILES

O=C(Cn1cnc2[nH]ncc2c1=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Cn1cnc2[nH]ncc2c1=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 91 chemicals

N-(3,4-Dimethylphenyl)-2-(1-methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)acetamide chemical structure, C16H17N5O2, CAS 866843-49-4

N-(3,4-Dimethylphenyl)-2-(1-methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)acetamide

CAS 866843-49-4C₁₆H₁₇N₅O₂

N-(4-Fluorophenyl)-2-(1-methyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)acetamide chemical structure, C14H12FN5O2, CAS 866843-51-8

N-(4-Fluorophenyl)-2-(1-methyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)acetamide

CAS 866843-51-8C₁₄H₁₂FN₅O₂

N-(2-Ethoxyphenyl)-2-(1-methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)acetamide chemical structure, C16H17N5O3, CAS 866843-53-0

N-(2-Ethoxyphenyl)-2-(1-methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)acetamide

CAS 866843-53-0C₁₆H₁₇N₅O₃

2-(1-Methyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-(2,4,6-trimethylphenyl)acetamide chemical structure, C17H19N5O2, CAS 866843-54-1

2-(1-Methyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-(2,4,6-trimethylphenyl)acetamide

CAS 866843-54-1C₁₇H₁₉N₅O₂

N-(4-Bromophenyl)-2-(1-methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)acetamide chemical structure, C14H12BrN5O2, CAS 866843-55-2

N-(4-Bromophenyl)-2-(1-methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)acetamide

CAS 866843-55-2C₁₄H₁₂BrN₅O₂

N-(4-Ethylphenyl)-2-(1-methyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)acetamide chemical structure, C16H17N5O2, CAS 866844-57-7

N-(4-Ethylphenyl)-2-(1-methyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)acetamide

CAS 866844-57-7C₁₆H₁₇N₅O₂

Ethyl 4-(2-{1-methyl-4-oxo-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-5-yl}acetamido)benzoate chemical structure, C17H17N5O4, CAS 866844-58-8

Ethyl 4-(2-{1-methyl-4-oxo-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-5-yl}acetamido)benzoate

CAS 866844-58-8C₁₇H₁₇N₅O₄

N-(4-Ethoxyphenyl)-2-(1-methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)acetamide chemical structure, C16H17N5O3, CAS 866870-30-6

N-(4-Ethoxyphenyl)-2-(1-methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)acetamide

CAS 866870-30-6C₁₆H₁₇N₅O₃

N-(3-Methoxyphenyl)-2-(1-methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)acetamide chemical structure, C15H15N5O3, CAS 866870-32-8

N-(3-Methoxyphenyl)-2-(1-methyl-4-oxo-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)acetamide

CAS 866870-32-8C₁₅H₁₅N₅O₃

2-(1-tert-Butyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-(4-methylphenyl)acetamide chemical structure, C18H21N5O2, CAS 863447-66-9

2-(1-tert-Butyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-(4-methylphenyl)acetamide

CAS 863447-66-9C₁₈H₂₁N₅O₂

2-(1-tert-Butyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-phenylacetamide chemical structure, C17H19N5O2, CAS 863447-62-5

2-(1-tert-Butyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-phenylacetamide

CAS 863447-62-5C₁₇H₁₉N₅O₂

N-(4-Acetamidophenyl)-2-(1-(tert-butyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetamide chemical structure, C19H22N6O3, CAS 863448-03-7

N-(4-Acetamidophenyl)-2-(1-(tert-butyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetamide

CAS 863448-03-7C₁₉H₂₂N₆O₃

Ethyl 2-(2-(1-(tert-butyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetamido)benzoate chemical structure, C20H23N5O4, CAS 863447-98-7

Ethyl 2-(2-(1-(tert-butyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)acetamido)benzoate

CAS 863447-98-7C₂₀H₂₃N₅O₄

2-(1-tert-Butyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-(4-chlorophenyl)acetamide chemical structure, C17H18ClN5O2, CAS 863447-77-2

2-(1-tert-Butyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-(4-chlorophenyl)acetamide

CAS 863447-77-2C₁₇H₁₈ClN₅O₂

2-(1-(tert-Butyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)-N-(m-tolyl)acetamide chemical structure, C18H21N5O2, CAS 863447-65-8

2-(1-(tert-Butyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)-N-(m-tolyl)acetamide

CAS 863447-65-8C₁₈H₂₁N₅O₂

2-(1-tert-Butyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-(2,3-dimethylphenyl)acetamide chemical structure, C19H23N5O2, CAS 863447-67-0

2-(1-tert-Butyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-(2,3-dimethylphenyl)acetamide

CAS 863447-67-0C₁₉H₂₃N₅O₂

2-(1-(tert-Butyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)-N-(2,5-dimethylphenyl)acetamide chemical structure, C19H23N5O2, CAS 863447-68-1

2-(1-(tert-Butyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)-N-(2,5-dimethylphenyl)acetamide

CAS 863447-68-1C₁₉H₂₃N₅O₂

2-(1-tert-Butyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-(2,4-dimethylphenyl)acetamide chemical structure, C19H23N5O2, CAS 863447-69-2

2-(1-tert-Butyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-(2,4-dimethylphenyl)acetamide

CAS 863447-69-2C₁₉H₂₃N₅O₂

2-(1-tert-Butyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-(3,5-dimethylphenyl)acetamide chemical structure, C19H23N5O2, CAS 863447-70-5

2-(1-tert-Butyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-(3,5-dimethylphenyl)acetamide

CAS 863447-70-5C₁₉H₂₃N₅O₂

2-(1-(tert-Butyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)-N-mesitylacetamide chemical structure, C20H25N5O2, CAS 863447-71-6

2-(1-(tert-Butyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)-N-mesitylacetamide

CAS 863447-71-6C₂₀H₂₅N₅O₂

2-(1-(tert-Butyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)-N-(4-ethylphenyl)acetamide chemical structure, C19H23N5O2, CAS 863447-72-7

2-(1-(tert-Butyl)-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-5(4H)-yl)-N-(4-ethylphenyl)acetamide

CAS 863447-72-7C₁₉H₂₃N₅O₂

2-(1-tert-Butyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-(4-butylphenyl)acetamide chemical structure, C21H27N5O2, CAS 896678-03-8

2-(1-tert-Butyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-(4-butylphenyl)acetamide

CAS 896678-03-8C₂₁H₂₇N₅O₂

2-(1-tert-Butyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-(2-fluorophenyl)acetamide chemical structure, C17H18FN5O2, CAS 863447-73-8

2-(1-tert-Butyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-(2-fluorophenyl)acetamide

CAS 863447-73-8C₁₇H₁₈FN₅O₂

2-(1-tert-Butyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-(3-fluorophenyl)acetamide chemical structure, C17H18FN5O2, CAS 863447-74-9

2-(1-tert-Butyl-4-oxopyrazolo[3,4-d]pyrimidin-5-yl)-N-(3-fluorophenyl)acetamide

CAS 863447-74-9C₁₇H₁₈FN₅O₂