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Murcko scaffold

3-Benzyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine scaffold

26 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
26
With full pages
3
Scaffold SMILES

c1ccc(Cc2nnc3n2CCNC3)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3-Benzyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine page
Murcko scaffold c1ccc(Cc2nnc3n2CCNC3)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

3-Benzyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C12H14N4, CAS 1035454-21-7
3-Benzyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine
CAS 1035454-21-7C12H14N4
3-(4-Bromobenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C12H13BrN4, CAS 1274593-71-3
3-(4-Bromobenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
CAS 1274593-71-3C12H13BrN4
3-(3-Methoxybenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C13H16N4O, CAS 1159553-83-9
3-(3-Methoxybenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
CAS 1159553-83-9C13H16N4O
3-(4-Chlorobenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C12H13ClN4, CAS 1271378-73-4
3-(4-Chlorobenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
CAS 1271378-73-4C12H13ClN4
3-[(2-Fluorophenyl)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C12H13FN4, CAS 1159542-76-3
3-[(2-Fluorophenyl)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine
CAS 1159542-76-3C12H13FN4
3-(4-Methylbenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C13H16N4, CAS 1159553-70-4
3-(4-Methylbenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
CAS 1159553-70-4C13H16N4
3-(3-Chlorobenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C12H13ClN4, CAS 1272306-59-8
3-(3-Chlorobenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
CAS 1272306-59-8C12H13ClN4
3-[(3-Bromophenyl)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C12H13BrN4, CAS 1272253-42-5
3-[(3-Bromophenyl)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine
CAS 1272253-42-5C12H13BrN4
3-(4-Fluorobenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C12H13FN4, CAS 1159553-30-6
3-(4-Fluorobenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
CAS 1159553-30-6C12H13FN4
3-((3-Fluorophenyl)methyl)-5H,6H,7H,8H-(1,2,4)triazolo(4,3-a)pyrazine chemical structure, C12H13FN4, CAS 1159553-28-2
3-((3-Fluorophenyl)methyl)-5H,6H,7H,8H-(1,2,4)triazolo(4,3-a)pyrazine
CAS 1159553-28-2C12H13FN4
3-[(2-Chlorophenyl)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C12H13ClN4, CAS 1283439-01-9
3-[(2-Chlorophenyl)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine
CAS 1283439-01-9C12H13ClN4
3-(2-Methylbenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C13H16N4, CAS 1159553-72-6
3-(2-Methylbenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
CAS 1159553-72-6C13H16N4
3-(2-Methoxybenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C13H16N4O, CAS 1159553-80-6
3-(2-Methoxybenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
CAS 1159553-80-6C13H16N4O
3-(4-(Trifluoromethyl)benzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C13H13F3N4, CAS 1468941-45-8
3-(4-(Trifluoromethyl)benzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
CAS 1468941-45-8C13H13F3N4
3-[(2,3-Difluorophenyl)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C12H12F2N4, CAS 1159553-64-6
3-[(2,3-Difluorophenyl)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine
CAS 1159553-64-6C12H12F2N4
3-[(2,6-Difluorophenyl)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C12H12F2N4, CAS 1518948-39-4
3-[(2,6-Difluorophenyl)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine
CAS 1518948-39-4C12H12F2N4
3-[(3-Bromophenyl)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine dihydrochloride chemical structure, C12H15BrCl2N4, CAS 1798729-90-4
3-[(3-Bromophenyl)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine dihydrochloride
CAS 1798729-90-4C12H15BrCl2N4
3-[(3-Bromophenyl)methyl]-7-(prop-2-yn-1-yl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine chemical structure, C15H15BrN4, CAS 1808900-81-3
3-[(3-Bromophenyl)methyl]-7-(prop-2-yn-1-yl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine
CAS 1808900-81-3C15H15BrN4
3-(4-Fluorobenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride chemical structure, C12H14ClFN4, CAS 2089325-31-3
3-(4-Fluorobenzyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride
CAS 2089325-31-3C12H14ClFN4
1-[3-[(3-Fluorophenyl)methyl]-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]prop-2-en-1-one chemical structure, C15H15FN4O, CAS 2189499-05-4
1-[3-[(3-Fluorophenyl)methyl]-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]prop-2-en-1-one
CAS 2189499-05-4C15H15FN4O
1-(3-Benzyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)prop-2-en-1-one chemical structure, C15H16N4O, CAS 2175581-24-3
1-(3-Benzyl-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)prop-2-en-1-one
CAS 2175581-24-3C15H16N4O
2-Chloro-1-[3-[(2,6-difluorophenyl)methyl]-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]propan-1-one chemical structure, C15H15ClF2N4O, CAS 2411224-30-9
2-Chloro-1-[3-[(2,6-difluorophenyl)methyl]-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]propan-1-one
CAS 2411224-30-9C15H15ClF2N4O
Methyl (2E)-4-{3-[(2-fluorophenyl)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl}-4-oxobut-2-enoate chemical structure, C17H17FN4O3, CAS 2411325-95-4
Methyl (2E)-4-{3-[(2-fluorophenyl)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl}-4-oxobut-2-enoate
CAS 2411325-95-4C17H17FN4O3
1-{3-[(2,6-Difluorophenyl)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl}prop-2-en-1-one chemical structure, C15H14F2N4O, CAS 2308230-28-4
1-{3-[(2,6-Difluorophenyl)methyl]-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl}prop-2-en-1-one
CAS 2308230-28-4C15H14F2N4O