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Murcko scaffold

2-Hydroxy-4-phenylthiazole scaffold

73 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 12
Chemicals: 73
With full pages: 21

Scaffold SMILES

O=c1[nH]c(-c2ccccc2)cs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 2-Hydroxy-4-phenylthiazole page

Murcko scaffold O=c1[nH]c(-c2ccccc2)cs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 73 chemicals

4-(4-Chlorophenyl)-2-hydroxythiazole chemical structure, C9H6ClNOS, CAS 2103-98-2

4-(4-Chlorophenyl)-2-hydroxythiazole

CAS 2103-98-2C₉H₆ClNOS

2-Hydroxy-4-phenylthiazole chemical structure, C9H7NOS, CAS 3884-31-9

2-Hydroxy-4-phenylthiazole

CAS 3884-31-9C₉H₇NOS

4-(4-Bromophenyl)-2-hydroxythiazole chemical structure, C9H6BrNOS, CAS 3884-34-2

4-(4-Bromophenyl)-2-hydroxythiazole

CAS 3884-34-2C₉H₆BrNOS

4-(4-Methylphenyl)-2,3-dihydro-1,3-thiazol-2-one chemical structure, C10H9NOS, CAS 2103-90-4

4-(4-Methylphenyl)-2,3-dihydro-1,3-thiazol-2-one

CAS 2103-90-4C₁₀H₉NOS

4-(2,5-Dimethoxy-phenyl)-2-oxo-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester chemical structure, C14H15NO5S, CAS 886497-78-5

4-(2,5-Dimethoxy-phenyl)-2-oxo-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester

CAS 886497-78-5C₁₄H₁₅NO₅S

Ethyl 4-(2,4-dimethoxyphenyl)-2-oxo-2,3-dihydrothiazole-5-carboxylate chemical structure, C14H15NO5S, CAS 886497-82-1

Ethyl 4-(2,4-dimethoxyphenyl)-2-oxo-2,3-dihydrothiazole-5-carboxylate

CAS 886497-82-1C₁₄H₁₅NO₅S

4-(3,4-Dimethoxy-phenyl)-2-oxo-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester chemical structure, C14H15NO5S, CAS 886497-86-5

4-(3,4-Dimethoxy-phenyl)-2-oxo-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester

CAS 886497-86-5C₁₄H₁₅NO₅S

4-(3,4-Dimethyl-phenyl)-2-oxo-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester chemical structure, C14H15NO3S, CAS 886497-90-1

4-(3,4-Dimethyl-phenyl)-2-oxo-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester

CAS 886497-90-1C₁₄H₁₅NO₃S

4-(4-Methoxy-phenyl)-2-oxo-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester chemical structure, C13H13NO4S, CAS 886497-95-6

4-(4-Methoxy-phenyl)-2-oxo-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester

CAS 886497-95-6C₁₃H₁₃NO₄S

4-(3-Methoxy-phenyl)-2-oxo-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester chemical structure, C13H13NO4S, CAS 886497-99-0

4-(3-Methoxy-phenyl)-2-oxo-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester

CAS 886497-99-0C₁₃H₁₃NO₄S

Ethyl 2-oxo-4-(p-tolyl)-2,3-dihydrothiazole-5-carboxylate chemical structure, C13H13NO3S, CAS 886498-04-0

Ethyl 2-oxo-4-(p-tolyl)-2,3-dihydrothiazole-5-carboxylate

CAS 886498-04-0C₁₃H₁₃NO₃S

Ethyl 2-oxo-4-(m-tolyl)-2,3-dihydrothiazole-5-carboxylate chemical structure, C13H13NO3S, CAS 886497-34-3

Ethyl 2-oxo-4-(m-tolyl)-2,3-dihydrothiazole-5-carboxylate

CAS 886497-34-3C₁₃H₁₃NO₃S

Ethyl 4-(4-nitrophenyl)-2-oxo-2,3-dihydrothiazole-5-carboxylate chemical structure, C12H10N2O5S, CAS 886497-37-6

Ethyl 4-(4-nitrophenyl)-2-oxo-2,3-dihydrothiazole-5-carboxylate

CAS 886497-37-6C₁₂H₁₀N₂O₅S

Ethyl 4-(3-nitrophenyl)-2-oxo-2,3-dihydrothiazole-5-carboxylate chemical structure, C12H10N2O5S, CAS 247242-54-2

Ethyl 4-(3-nitrophenyl)-2-oxo-2,3-dihydrothiazole-5-carboxylate

CAS 247242-54-2C₁₂H₁₀N₂O₅S

4-(4-Fluoro-phenyl)-2-oxo-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester chemical structure, C12H10FNO3S, CAS 886497-41-2

4-(4-Fluoro-phenyl)-2-oxo-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester

CAS 886497-41-2C₁₂H₁₀FNO₃S

4-(4-Bromo-phenyl)-2-oxo-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester chemical structure, C12H10BrNO3S, CAS 886497-45-6

4-(4-Bromo-phenyl)-2-oxo-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester

CAS 886497-45-6C₁₂H₁₀BrNO₃S

Ethyl 4-(3-bromophenyl)-2-oxo-2,3-dihydrothiazole-5-carboxylate chemical structure, C12H10BrNO3S, CAS 886497-49-0

Ethyl 4-(3-bromophenyl)-2-oxo-2,3-dihydrothiazole-5-carboxylate

CAS 886497-49-0C₁₂H₁₀BrNO₃S

Ethyl 4-(2,4-dichlorophenyl)-2-oxo-2,3-dihydrothiazole-5-carboxylate chemical structure, C12H9Cl2NO3S, CAS 886497-52-5

Ethyl 4-(2,4-dichlorophenyl)-2-oxo-2,3-dihydrothiazole-5-carboxylate

CAS 886497-52-5C₁₂H₉Cl₂NO₃S

Ethyl 4-(4-chlorophenyl)-2-oxo-3H-1,3-thiazole-5-carboxylate chemical structure, C12H10ClNO3S, CAS 886498-09-5

Ethyl 4-(4-chlorophenyl)-2-oxo-3H-1,3-thiazole-5-carboxylate

CAS 886498-09-5C₁₂H₁₀ClNO₃S

4-(2-Chloro-phenyl)-2-oxo-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester chemical structure, C12H10ClNO3S, CAS 886498-14-2

4-(2-Chloro-phenyl)-2-oxo-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester

CAS 886498-14-2C₁₂H₁₀ClNO₃S

4-(4-Methoxyphenyl)-1,3-thiazol-2-ol chemical structure, C10H9NO2S, CAS 2104-03-2

4-(4-Methoxyphenyl)-1,3-thiazol-2-ol

CAS 2104-03-2C₁₀H₉NO₂S

4-(4-Nitrophenyl)-1,3-thiazol-2(3H)-one chemical structure, C9H6N2O3S, CAS 2104-08-7

4-(4-Nitrophenyl)-1,3-thiazol-2(3H)-one

CAS 2104-08-7C₉H₆N₂O₃S

Ethyl 2,3-dihydro-2-oxo-4-phenyl-5-thiazolecarboxylate chemical structure, C12H11NO3S, CAS 13950-67-9

Ethyl 2,3-dihydro-2-oxo-4-phenyl-5-thiazolecarboxylate

CAS 13950-67-9C₁₂H₁₁NO₃S

Ethyl 2,3-dihydro-2-oxo-4-[3-(trifluoromethyl)phenyl]-5-thiazolecarboxylate chemical structure, C13H10F3NO3S, CAS 74476-48-5

Ethyl 2,3-dihydro-2-oxo-4-[3-(trifluoromethyl)phenyl]-5-thiazolecarboxylate

CAS 74476-48-5C₁₃H₁₀F₃NO₃S