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Murcko scaffold

Ring system with 3 rings and 23 atoms

15 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
15
With full pages
3
Scaffold SMILES

O=S(=O)(c1ccccc1)N1CCC(CSc2ccccc2)CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=S(=O)(c1ccccc1)N1CCC(CSc2ccccc2)CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

4-{[(4-Methylphenyl)sulfanyl]methyl}-1-(phenylsulfonyl)-4-piperidinol chemical structure, C19H23NO3S2, CAS 478029-36-6
4-{[(4-Methylphenyl)sulfanyl]methyl}-1-(phenylsulfonyl)-4-piperidinol
CAS 478029-36-6C19H23NO3S2
1-[(4-Chlorophenyl)sulfonyl]-4-{[(4-methylphenyl)sulfanyl]methyl}-4-piperidinol chemical structure, C19H22ClNO3S2, CAS 478041-59-7
1-[(4-Chlorophenyl)sulfonyl]-4-{[(4-methylphenyl)sulfanyl]methyl}-4-piperidinol
CAS 478041-59-7C19H22ClNO3S2
4-{[(4-Fluorophenyl)sulfanyl]methyl}-1-(phenylsulfonyl)-4-piperidinol chemical structure, C18H20FNO3S2, CAS 478041-56-4
4-{[(4-Fluorophenyl)sulfanyl]methyl}-1-(phenylsulfonyl)-4-piperidinol
CAS 478041-56-4C18H20FNO3S2
4-[(Phenylsulfanyl)methyl]-1-(phenylsulfonyl)-4-piperidinol chemical structure, C18H21NO3S2, CAS 478041-55-3
4-[(Phenylsulfanyl)methyl]-1-(phenylsulfonyl)-4-piperidinol
CAS 478041-55-3C18H21NO3S2
4-{[(4-Chlorophenyl)sulfanyl]methyl}-1-(phenylsulfonyl)-4-piperidinol chemical structure, C18H20ClNO3S2, CAS 861212-70-6
4-{[(4-Chlorophenyl)sulfanyl]methyl}-1-(phenylsulfonyl)-4-piperidinol
CAS 861212-70-6C18H20ClNO3S2
4-{[(4-Chlorophenyl)sulfanyl]methyl}-1-[(4-chlorophenyl)sulfonyl]-4-piperidinol chemical structure, C18H19Cl2NO3S2, CAS 478041-58-6
4-{[(4-Chlorophenyl)sulfanyl]methyl}-1-[(4-chlorophenyl)sulfonyl]-4-piperidinol
CAS 478041-58-6C18H19Cl2NO3S2
4-{[(4-Bromophenyl)sulfanyl]methyl}-1-[(4-chlorophenyl)sulfonyl]-4-piperidinol chemical structure, C18H19BrClNO3S2, CAS 478041-70-2
4-{[(4-Bromophenyl)sulfanyl]methyl}-1-[(4-chlorophenyl)sulfonyl]-4-piperidinol
CAS 478041-70-2C18H19BrClNO3S2
1-(4-Chlorophenyl)sulfonyl-4-[(4-fluorophenyl)sulfanylmethyl]piperidin-4-ol chemical structure, C18H19ClFNO3S2, CAS 478041-71-3
1-(4-Chlorophenyl)sulfonyl-4-[(4-fluorophenyl)sulfanylmethyl]piperidin-4-ol
CAS 478041-71-3C18H19ClFNO3S2
1-(4-Chlorophenyl)sulfonyl-4-[(2-methoxyphenyl)sulfanylmethyl]piperidin-4-ol chemical structure, C19H22ClNO4S2, CAS 478041-72-4
1-(4-Chlorophenyl)sulfonyl-4-[(2-methoxyphenyl)sulfanylmethyl]piperidin-4-ol
CAS 478041-72-4C19H22ClNO4S2
4-(((4-Methoxyphenyl)thio)methyl)-1-(phenylsulfonyl)piperidine chemical structure, C19H23NO3S2, CAS 1421483-03-5
4-(((4-Methoxyphenyl)thio)methyl)-1-(phenylsulfonyl)piperidine
CAS 1421483-03-5C19H23NO3S2
1-((2,5-Dimethoxyphenyl)sulfonyl)-4-(((4-methoxyphenyl)thio)methyl)piperidine chemical structure, C21H27NO5S2, CAS 1421445-33-1
1-((2,5-Dimethoxyphenyl)sulfonyl)-4-(((4-methoxyphenyl)thio)methyl)piperidine
CAS 1421445-33-1C21H27NO5S2
1-(5-Fluoro-2-methoxybenzenesulfonyl)-4-{[(4-methoxyphenyl)sulfanyl]methyl}piperidine chemical structure, C20H24FNO4S2, CAS 1421477-78-2
1-(5-Fluoro-2-methoxybenzenesulfonyl)-4-{[(4-methoxyphenyl)sulfanyl]methyl}piperidine
CAS 1421477-78-2C20H24FNO4S2
1-((2-Methoxy-5-methylphenyl)sulfonyl)-4-(((4-methoxyphenyl)thio)methyl)piperidine chemical structure, C21H27NO4S2, CAS 1421462-98-7
1-((2-Methoxy-5-methylphenyl)sulfonyl)-4-(((4-methoxyphenyl)thio)methyl)piperidine
CAS 1421462-98-7C21H27NO4S2
1-(4-((4-(((4-Methoxyphenyl)thio)methyl)piperidin-1-yl)sulfonyl)phenyl)ethanone chemical structure, C21H25NO4S2, CAS 1421451-22-0
1-(4-((4-(((4-Methoxyphenyl)thio)methyl)piperidin-1-yl)sulfonyl)phenyl)ethanone
CAS 1421451-22-0C21H25NO4S2
1-((2,6-Difluorophenyl)sulfonyl)-4-(((4-methoxyphenyl)thio)methyl)piperidine chemical structure, C19H21F2NO3S2, CAS 1421471-89-7
1-((2,6-Difluorophenyl)sulfonyl)-4-(((4-methoxyphenyl)thio)methyl)piperidine
CAS 1421471-89-7C19H21F2NO3S2