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Murcko scaffold

2-(2,5-Dioxopyrrolidin-1-yl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide scaffold

18 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
18
With full pages
5
Scaffold SMILES

O=C(CN1C(=O)CCC1=O)Nc1nc(-c2ccccc2)cs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2-(2,5-Dioxopyrrolidin-1-yl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide page
Murcko scaffold O=C(CN1C(=O)CCC1=O)Nc1nc(-c2ccccc2)cs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

2-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]acetamide chemical structure, C16H15N3O4S, CAS 361167-69-3
2-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]acetamide
CAS 361167-69-3C16H15N3O4S
N-[4-(2,5-Dichlorophenyl)-1,3-thiazol-2-yl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide chemical structure, C15H11Cl2N3O3S, CAS 380180-45-0
N-[4-(2,5-Dichlorophenyl)-1,3-thiazol-2-yl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide
CAS 380180-45-0C15H11Cl2N3O3S
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide chemical structure, C15H12BrN3O3S, CAS 361167-70-6
N-[4-(4-Bromophenyl)-1,3-thiazol-2-yl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide
CAS 361167-70-6C15H12BrN3O3S
N-[4-(2,5-Dimethylphenyl)-1,3-thiazol-2-yl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide chemical structure, C17H17N3O3S, CAS 441289-44-7
N-[4-(2,5-Dimethylphenyl)-1,3-thiazol-2-yl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide
CAS 441289-44-7C17H17N3O3S
2-(2,5-Dioxopyrrolidin-1-yl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide chemical structure, C15H13N3O3S, CAS 313699-31-9
2-(2,5-Dioxopyrrolidin-1-yl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
CAS 313699-31-9C15H13N3O3S
2-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(2,4,6-trimethylphenyl)-1,3-thiazol-2-yl]acetamide chemical structure, C18H19N3O3S, CAS 361167-73-9
2-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(2,4,6-trimethylphenyl)-1,3-thiazol-2-yl]acetamide
CAS 361167-73-9C18H19N3O3S
2-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(2-methoxyphenyl)-1,3-thiazol-2-yl]acetamide chemical structure, C16H15N3O4S, CAS 392324-65-1
2-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(2-methoxyphenyl)-1,3-thiazol-2-yl]acetamide
CAS 392324-65-1C16H15N3O4S
N-[4-(3,4-Dimethoxyphenyl)-1,3-thiazol-2-yl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide chemical structure, C17H17N3O5S, CAS 392324-62-8
N-[4-(3,4-Dimethoxyphenyl)-1,3-thiazol-2-yl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide
CAS 392324-62-8C17H17N3O5S
2-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide chemical structure, C16H15N3O3S, CAS 361167-67-1
2-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-methylphenyl)-1,3-thiazol-2-yl]acetamide
CAS 361167-67-1C16H15N3O3S
N-[4-(2,4-Dichlorophenyl)-1,3-thiazol-2-yl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide chemical structure, C15H11Cl2N3O3S, CAS 477569-12-3
N-[4-(2,4-Dichlorophenyl)-1,3-thiazol-2-yl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide
CAS 477569-12-3C15H11Cl2N3O3S
N-[4-(2,4-Dimethylphenyl)-1,3-thiazol-2-yl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide chemical structure, C17H17N3O3S, CAS 392324-57-1
N-[4-(2,4-Dimethylphenyl)-1,3-thiazol-2-yl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide
CAS 392324-57-1C17H17N3O3S
2-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]acetamide chemical structure, C15H12FN3O3S, CAS 361167-75-1
2-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]acetamide
CAS 361167-75-1C15H12FN3O3S
N-[4-(3,4-Dimethylphenyl)-1,3-thiazol-2-yl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide chemical structure, C17H17N3O3S, CAS 361167-72-8
N-[4-(3,4-Dimethylphenyl)-1,3-thiazol-2-yl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide
CAS 361167-72-8C17H17N3O3S
N-[4-(2,4-Dimethoxyphenyl)-1,3-thiazol-2-yl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide chemical structure, C17H17N3O5S, CAS 361481-82-5
N-[4-(2,4-Dimethoxyphenyl)-1,3-thiazol-2-yl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide
CAS 361481-82-5C17H17N3O5S
N-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide chemical structure, C15H11Cl2N3O3S, CAS 476308-68-6
N-[4-(3,4-Dichlorophenyl)-1,3-thiazol-2-yl]-2-(2,5-dioxopyrrolidin-1-yl)acetamide
CAS 476308-68-6C15H11Cl2N3O3S
2-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]acetamide chemical structure, C18H19N3O3S, CAS 361167-74-0
2-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-propan-2-ylphenyl)-1,3-thiazol-2-yl]acetamide
CAS 361167-74-0C18H19N3O3S
2-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-ethylphenyl)-1,3-thiazol-2-yl]acetamide chemical structure, C17H17N3O3S, CAS 361167-68-2
2-(2,5-Dioxopyrrolidin-1-yl)-N-[4-(4-ethylphenyl)-1,3-thiazol-2-yl]acetamide
CAS 361167-68-2C17H17N3O3S
2-(2,5-Dioxopyrrolidin-1-yl)-N-(4-(4-propoxyphenyl)thiazol-2-yl)acetamide chemical structure, C18H19N3O4S, CAS 392324-75-3
2-(2,5-Dioxopyrrolidin-1-yl)-N-(4-(4-propoxyphenyl)thiazol-2-yl)acetamide
CAS 392324-75-3C18H19N3O4S