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Murcko scaffold

1(2H)-Isoquinolinone scaffold

1,331 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
1,331
With full pages
116
Scaffold SMILES

O=c1[nH]ccc2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1(2H)-Isoquinolinone page
Murcko scaffold O=c1[nH]ccc2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 1,331 chemicals

1,5-Isoquinolinediol chemical structure, C9H7NO2, CAS 5154-02-9
1,5-Isoquinolinediol
CAS 5154-02-9C9H7NO2
5-Aminoisoquinolin-1(2H)-one chemical structure, C9H8N2O, CAS 93117-08-9
5-Aminoisoquinolin-1(2H)-one
CAS 93117-08-9C9H8N2O
Tilisolol chemical structure, C17H24N2O3, CAS 85136-71-6
Tilisolol
CAS 85136-71-6C17H24N2O3
1(2H)-Isoquinolinone chemical structure, C9H7NO, CAS 491-30-5
1(2H)-Isoquinolinone
CAS 491-30-5C9H7NO
1(2H)-Isoquinolinone, 2-methyl- chemical structure, C10H9NO, CAS 4594-71-2
1(2H)-Isoquinolinone, 2-methyl-
CAS 4594-71-2C10H9NO
4-Hydroxy-3-methyl-2H-isoquinolin-1-one chemical structure, C10H9NO2, CAS 5423-95-0
4-Hydroxy-3-methyl-2H-isoquinolin-1-one
CAS 5423-95-0C10H9NO2
5-Nitro-1,2-dihydroisoquinolin-1-one chemical structure, C9H6N2O3, CAS 82827-08-5
5-Nitro-1,2-dihydroisoquinolin-1-one
CAS 82827-08-5C9H6N2O3
Ethyl 4-hydroxy-1-oxo-1,2-dihydroisoquinoline-3-carboxylate chemical structure, C12H11NO4, CAS 14174-93-7
Ethyl 4-hydroxy-1-oxo-1,2-dihydroisoquinoline-3-carboxylate
CAS 14174-93-7C12H11NO4
4-Hydroxyisoquinolin-1(2H)-one chemical structure, C9H7NO2, CAS 30081-72-2
4-Hydroxyisoquinolin-1(2H)-one
CAS 30081-72-2C9H7NO2
1-Oxo-1,2-dihydroisoquinoline-3-carboxylic acid chemical structure, C10H7NO3, CAS 7509-13-9
1-Oxo-1,2-dihydroisoquinoline-3-carboxylic acid
CAS 7509-13-9C10H7NO3
2-Methyl-5-nitro-2H-isoquinolin-1-one chemical structure, C10H8N2O3, CAS 42792-96-1
2-Methyl-5-nitro-2H-isoquinolin-1-one
CAS 42792-96-1C10H8N2O3
4-Bromo-2-methylisoquinolin-1(2H)-one chemical structure, C10H8BrNO, CAS 33930-63-1
4-Bromo-2-methylisoquinolin-1(2H)-one
CAS 33930-63-1C10H8BrNO
2-Methyl-4-nitroisoquinolin-1(2H)-one chemical structure, C10H8N2O3, CAS 33930-79-9
2-Methyl-4-nitroisoquinolin-1(2H)-one
CAS 33930-79-9C10H8N2O3
4-Bromo-1-hydroxyisoquinoline chemical structure, C9H6BrNO, CAS 3951-95-9
4-Bromo-1-hydroxyisoquinoline
CAS 3951-95-9C9H6BrNO
4-Chloro-2-methylisoquinolin-1(2H)-one chemical structure, C10H8ClNO, CAS 27187-01-5
4-Chloro-2-methylisoquinolin-1(2H)-one
CAS 27187-01-5C10H8ClNO
1-Hydroxyisoquinoline 2-oxide chemical structure, C9H7NO2, CAS 21201-50-3
1-Hydroxyisoquinoline 2-oxide
CAS 21201-50-3C9H7NO2
2-Ethyl-1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid chemical structure, C12H11NO3, CAS 500786-62-9
2-Ethyl-1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid
CAS 500786-62-9C12H11NO3
3-Isoquinolinecarboxamide, 1,2-dihydro-2,4-dimethyl-N-(2-(dimethylamino)ethyl)-1-oxo- chemical structure, C16H21N3O2, CAS 89929-04-4
3-Isoquinolinecarboxamide, 1,2-dihydro-2,4-dimethyl-N-(2-(dimethylamino)ethyl)-1-oxo-
CAS 89929-04-4C16H21N3O2
8-Methylisoquinolin-1(2H)-one chemical structure, C10H9NO, CAS 116409-35-9
8-Methylisoquinolin-1(2H)-one
CAS 116409-35-9C10H9NO
1-Oxo-1,2-dihydroisoquinoline-8-carboxylic acid chemical structure, C10H7NO3, CAS 116409-31-5
1-Oxo-1,2-dihydroisoquinoline-8-carboxylic acid
CAS 116409-31-5C10H7NO3
4-Amino-2-methylisoquinolin-1(2H)-one chemical structure, C10H10N2O, CAS 54931-53-2
4-Amino-2-methylisoquinolin-1(2H)-one
CAS 54931-53-2C10H10N2O
4-Amino-2,3-dimethyl-1(2H)-isoquinolinone chemical structure, C11H12N2O, CAS 54931-70-3
4-Amino-2,3-dimethyl-1(2H)-isoquinolinone
CAS 54931-70-3C11H12N2O
Methyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate chemical structure, C11H9NO3, CAS 69454-42-8
Methyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate
CAS 69454-42-8C11H9NO3
Methyl 1-oxo-2H-isoquinoline-4-carboxylate chemical structure, C11H9NO3, CAS 37497-84-0
Methyl 1-oxo-2H-isoquinoline-4-carboxylate
CAS 37497-84-0C11H9NO3