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Murcko scaffold

1-(1,3,4-Thiadiazol-2-yl)piperazine scaffold

51 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
51
With full pages
5
Scaffold SMILES

c1nnc(N2CCNCC2)s1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(1,3,4-Thiadiazol-2-yl)piperazine page
Murcko scaffold c1nnc(N2CCNCC2)s1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 51 chemicals

Piperazine, 1-methyl-4-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)- chemical structure, C8H11F3N4S, CAS 57709-34-9
Piperazine, 1-methyl-4-(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)-
CAS 57709-34-9C8H11F3N4S
5-(4-Methylpiperazin-1-yl)-1,3,4-thiadiazol-2-amine chemical structure, C7H13N5S, CAS 71125-50-3
5-(4-Methylpiperazin-1-yl)-1,3,4-thiadiazol-2-amine
CAS 71125-50-3C7H13N5S
1-[5-(Trifluoromethyl)-1,3,4-thiadiazol-2-yl]piperazine chemical structure, C7H9F3N4S, CAS 562858-09-7
1-[5-(Trifluoromethyl)-1,3,4-thiadiazol-2-yl]piperazine
CAS 562858-09-7C7H9F3N4S
Piperazine, 1-(5-ethyl-1,3,4-thiadiazol-2-yl)-4-methyl- chemical structure, C9H16N4S, CAS 57709-33-8
Piperazine, 1-(5-ethyl-1,3,4-thiadiazol-2-yl)-4-methyl-
CAS 57709-33-8C9H16N4S
1-Piperazineacetamide, 4-methyl-N-(5-methyl-1,3,4-thiazol-2-yl)- chemical structure, C10H17N5OS, CAS 141400-68-2
1-Piperazineacetamide, 4-methyl-N-(5-methyl-1,3,4-thiazol-2-yl)-
CAS 141400-68-2C10H17N5OS
1-Piperazineacetamide, N-(5-methyl-1,3,4-thiadiazol-2-yl)- chemical structure, C9H15N5OS, CAS 141400-72-8
1-Piperazineacetamide, N-(5-methyl-1,3,4-thiadiazol-2-yl)-
CAS 141400-72-8C9H15N5OS
1-Piperazineacetamide, N-(5-ethyl-1,3,4-thiadiazol-2-yl)- chemical structure, C10H17N5OS, CAS 141400-73-9
1-Piperazineacetamide, N-(5-ethyl-1,3,4-thiadiazol-2-yl)-
CAS 141400-73-9C10H17N5OS
4-(5-Amino-1,3,4-thiadiazol-2-yl)piperazine-1-carbaldehyde chemical structure, C7H11N5OS, CAS 941867-61-4
4-(5-Amino-1,3,4-thiadiazol-2-yl)piperazine-1-carbaldehyde
CAS 941867-61-4C7H11N5OS
1-(5-Methyl-1,3,4-thiadiazol-2-yl)piperazine chemical structure, C7H12N4S, CAS 98962-20-0
1-(5-Methyl-1,3,4-thiadiazol-2-yl)piperazine
CAS 98962-20-0C7H12N4S
1-(1,3,4-Thiadiazol-2-yl)piperazine chemical structure, C6H10N4S, CAS 72396-58-8
1-(1,3,4-Thiadiazol-2-yl)piperazine
CAS 72396-58-8C6H10N4S
1-(1,3,4-Thiadiazol-2-yl)piperazine dihydrochloride chemical structure, C6H12Cl2N4S, CAS 67869-69-6
1-(1,3,4-Thiadiazol-2-yl)piperazine dihydrochloride
CAS 67869-69-6C6H12Cl2N4S
tert-Butyl 4-(5-amino-1,3,4-thiadiazol-2-yl)piperazine-1-carboxylate chemical structure, C11H19N5O2S, CAS 244201-29-4
tert-Butyl 4-(5-amino-1,3,4-thiadiazol-2-yl)piperazine-1-carboxylate
CAS 244201-29-4C11H19N5O2S
2-((5-(4-Methylpiperazin-1-yl)-1,3,4-thiadiazol-2-yl)thio)acetamide chemical structure, C9H15N5OS2, CAS 1105251-22-6
2-((5-(4-Methylpiperazin-1-yl)-1,3,4-thiadiazol-2-yl)thio)acetamide
CAS 1105251-22-6C9H15N5OS2
2-(Isopentylthio)-5-(4-methylpiperazin-1-yl)-1,3,4-thiadiazole chemical structure, C12H22N4S2, CAS 1105220-96-9
2-(Isopentylthio)-5-(4-methylpiperazin-1-yl)-1,3,4-thiadiazole
CAS 1105220-96-9C12H22N4S2
2-((5-(4-(2-Methoxyacetyl)piperazin-1-yl)-1,3,4-thiadiazol-2-yl)thio)acetamide chemical structure, C11H17N5O3S2, CAS 1105197-55-4
2-((5-(4-(2-Methoxyacetyl)piperazin-1-yl)-1,3,4-thiadiazol-2-yl)thio)acetamide
CAS 1105197-55-4C11H17N5O3S2
2-((5-(4-Pentanoylpiperazin-1-yl)-1,3,4-thiadiazol-2-yl)thio)acetamide chemical structure, C13H21N5O2S2, CAS 1105197-85-0
2-((5-(4-Pentanoylpiperazin-1-yl)-1,3,4-thiadiazol-2-yl)thio)acetamide
CAS 1105197-85-0C13H21N5O2S2
2-((5-(4-Pivaloylpiperazin-1-yl)-1,3,4-thiadiazol-2-yl)thio)acetamide chemical structure, C13H21N5O2S2, CAS 1105224-78-9
2-((5-(4-Pivaloylpiperazin-1-yl)-1,3,4-thiadiazol-2-yl)thio)acetamide
CAS 1105224-78-9C13H21N5O2S2
2-{[5-(4-Acetylpiperazin-1-yl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N-methylacetamide chemical structure, C11H17N5O2S2, CAS 1105199-13-0
2-{[5-(4-Acetylpiperazin-1-yl)-1,3,4-thiadiazol-2-yl]sulfanyl}-N-methylacetamide
CAS 1105199-13-0C11H17N5O2S2
N-Isopropyl-2-((5-(4-(2-methoxyacetyl)piperazin-1-yl)-1,3,4-thiadiazol-2-yl)thio)acetamide chemical structure, C14H23N5O3S2, CAS 1105200-11-0
N-Isopropyl-2-((5-(4-(2-methoxyacetyl)piperazin-1-yl)-1,3,4-thiadiazol-2-yl)thio)acetamide
CAS 1105200-11-0C14H23N5O3S2
N-Isopropyl-2-((5-(4-propionylpiperazin-1-yl)-1,3,4-thiadiazol-2-yl)thio)acetamide chemical structure, C14H23N5O2S2, CAS 1105226-94-5
N-Isopropyl-2-((5-(4-propionylpiperazin-1-yl)-1,3,4-thiadiazol-2-yl)thio)acetamide
CAS 1105226-94-5C14H23N5O2S2
2-((5-(4-(3,3-Dimethylbutanoyl)piperazin-1-yl)-1,3,4-thiadiazol-2-yl)thio)-N-isopropylacetamide chemical structure, C17H29N5O2S2, CAS 1105200-42-7
2-((5-(4-(3,3-Dimethylbutanoyl)piperazin-1-yl)-1,3,4-thiadiazol-2-yl)thio)-N-isopropylacetamide
CAS 1105200-42-7C17H29N5O2S2
Ethyl 2-(4-(5-((2-(isopropylamino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)piperazin-1-yl)-2-oxoacetate chemical structure, C15H23N5O4S2, CAS 1105227-36-8
Ethyl 2-(4-(5-((2-(isopropylamino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)piperazin-1-yl)-2-oxoacetate
CAS 1105227-36-8C15H23N5O4S2
Ethyl 4-(4-(5-((2-(isopropylamino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)piperazin-1-yl)-4-oxobutanoate chemical structure, C17H27N5O4S2, CAS 1105200-88-1
Ethyl 4-(4-(5-((2-(isopropylamino)-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)piperazin-1-yl)-4-oxobutanoate
CAS 1105200-88-1C17H27N5O4S2
Ethyl 4-[5-({[(propan-2-yl)carbamoyl]methyl}sulfanyl)-1,3,4-thiadiazol-2-yl]piperazine-1-carboxylate chemical structure, C14H23N5O3S2, CAS 1105227-44-8
Ethyl 4-[5-({[(propan-2-yl)carbamoyl]methyl}sulfanyl)-1,3,4-thiadiazol-2-yl]piperazine-1-carboxylate
CAS 1105227-44-8C14H23N5O3S2