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Murcko scaffold

Ring system with 4 rings and 24 atoms

55 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
55
With full pages
1
Scaffold SMILES

O=C1CCC(N2C(=O)c3ccc(N4CCCC4)cc3C2=O)C(=O)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CCC(N2C(=O)c3ccc(N4CCCC4)cc3C2=O)C(=O)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 55 of 55 chemicals

5-[3-(2-Aminoethoxy)pyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C19H22N4O5, CAS 2703770-68-5
5-[3-(2-Aminoethoxy)pyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2703770-68-5C19H22N4O5
rac-5-[(3R,4R)-3-(2-Aminoethyl)-4-methylpyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C20H24N4O4, CAS 2731011-44-0
rac-5-[(3R,4R)-3-(2-Aminoethyl)-4-methylpyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2731011-44-0C20H24N4O4
rac-5-[(3R,4S)-3-Amino-4-(2,2-dimethylpropyl)pyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione chemical structure, C22H28N4O4, CAS 2731013-45-7
rac-5-[(3R,4S)-3-Amino-4-(2,2-dimethylpropyl)pyrrolidin-1-yl]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CAS 2731013-45-7C22H28N4O4
1-[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]pyrrolidine-3-carboxylic acid chemical structure, C18H17N3O6, CAS 2864408-82-0
1-[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]pyrrolidine-3-carboxylic acid
CAS 2864408-82-0C18H17N3O6
5-(3-Aminopyrrolidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride chemical structure, C17H19ClN4O4, CAS 3028141-03-6
5-(3-Aminopyrrolidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride
CAS 3028141-03-6C17H19ClN4O4
2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-((S)-3-(2-hydroxyethyl)pyrrolidin-1-yl)isoindoline-1,3-dione chemical structure, C19H20FN3O5, CAS 2837986-20-4
2-(2,6-Dioxopiperidin-3-yl)-5-fluoro-6-((S)-3-(2-hydroxyethyl)pyrrolidin-1-yl)isoindoline-1,3-dione
CAS 2837986-20-4C19H20FN3O5
[(3R)-1-[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]pyrrolidin-3-yl]methyl methanesulfonate chemical structure, C19H21N3O7S, CAS 3061690-80-7
[(3R)-1-[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]pyrrolidin-3-yl]methyl methanesulfonate
CAS 3061690-80-7C19H21N3O7S