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Murcko scaffold

5H,6H,7H,8H-Pyrido[3,4-d]pyrimidine scaffold

115 chemicals on CompoundList share this ring system.

Rings: 2
Scaffold atoms: 10
Chemicals: 115
With full pages: 9

Scaffold SMILES

c1ncc2c(n1)CNCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold Open the 5H,6H,7H,8H-Pyrido[3,4-d]pyrimidine page

Murcko scaffold c1ncc2c(n1)CNCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 115 chemicals

2-(Ethylthio)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride chemical structure, C9H14ClN3S, CAS 647863-18-1

2-(Ethylthio)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

CAS 647863-18-1C₉H₁₄ClN₃S

2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine chemical structure, C8H8F3N3, CAS 647863-02-3

2-(Trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

CAS 647863-02-3C₈H₈F₃N₃

4-Chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidine chemical structure, C8H7ClF3N3, CAS 647863-08-9

4-Chloro-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidine

CAS 647863-08-9C₈H₇ClF₃N₃

5H,6H,7H,8H-Pyrido[3,4-d]pyrimidine chemical structure, C7H9N3, CAS 781595-43-5

5H,6H,7H,8H-Pyrido[3,4-d]pyrimidine

CAS 781595-43-5C₇H₉N₃

4-Methoxy-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine chemical structure, C8H11N3O, CAS 192869-82-2

4-Methoxy-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

CAS 192869-82-2C₈H₁₁N₃O

5,6,7,8-Tetrahydropyrido[3,4-d]pyrimidine hydrochloride chemical structure, C7H10ClN3, CAS 192869-79-7

5,6,7,8-Tetrahydropyrido[3,4-d]pyrimidine hydrochloride

CAS 192869-79-7C₇H₁₀ClN₃

tert-Butyl 2,4-dichloro-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate chemical structure, C12H15Cl2N3O2, CAS 916420-27-4

tert-Butyl 2,4-dichloro-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate

CAS 916420-27-4C₁₂H₁₅Cl₂N₃O₂

2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine chemical structure, C7H7Cl2N3, CAS 1000578-08-4

2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

CAS 1000578-08-4C₇H₇Cl₂N₃

4-Chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine chemical structure, C7H8ClN3, CAS 1196157-06-8

4-Chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

CAS 1196157-06-8C₇H₈ClN₃

2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride chemical structure, C7H8Cl3N3, CAS 1187830-76-7

2,4-Dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

CAS 1187830-76-7C₇H₈Cl₃N₃

tert-Butyl 5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate chemical structure, C12H17N3O2, CAS 1174007-81-8

tert-Butyl 5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate

CAS 1174007-81-8C₁₂H₁₇N₃O₂

4-Methoxy-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride chemical structure, C8H12ClN3O, CAS 1187830-77-8

4-Methoxy-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

CAS 1187830-77-8C₈H₁₂ClN₃O

tert-Butyl 4-chloro-5H,6H,7H,8H-pyrido(3,4-d)pyrimidine-7-carboxylate chemical structure, C12H16ClN3O2, CAS 1053656-57-7

tert-Butyl 4-chloro-5H,6H,7H,8H-pyrido(3,4-d)pyrimidine-7-carboxylate

CAS 1053656-57-7C₁₂H₁₆ClN₃O₂

7-Boc-2-(methylthio)-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidine chemical structure, C13H19N3O2S, CAS 1226776-86-8

7-Boc-2-(methylthio)-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidine

CAS 1226776-86-8C₁₃H₁₉N₃O₂S

2-(Methylthio)-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidine hydrochloride chemical structure, C8H12ClN3S, CAS 1226776-81-3

2-(Methylthio)-5,6,7,8-tetrahydropyrido[3,4-D]pyrimidine hydrochloride

CAS 1226776-81-3C₈H₁₂ClN₃S

2-(Methylthio)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine chemical structure, C8H11N3S, CAS 1226851-41-7

2-(Methylthio)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

CAS 1226851-41-7C₈H₁₁N₃S

2-Methyl-5H,6H,7H,8H-pyrido[3,4-d]pyrimidine chemical structure, C8H11N3, CAS 1159882-42-4

2-Methyl-5H,6H,7H,8H-pyrido[3,4-d]pyrimidine

CAS 1159882-42-4C₈H₁₁N₃

2-Ethyl-5H,6H,7H,8H-pyrido[3,4-d]pyrimidine chemical structure, C9H13N3, CAS 1334146-17-6

2-Ethyl-5H,6H,7H,8H-pyrido[3,4-d]pyrimidine

CAS 1334146-17-6C₉H₁₃N₃

2-(Propan-2-yl)-5H,6H,7H,8H-pyrido[3,4-d]pyrimidine chemical structure, C10H15N3, CAS 1354963-17-9

2-(Propan-2-yl)-5H,6H,7H,8H-pyrido[3,4-d]pyrimidine

CAS 1354963-17-9C₁₀H₁₅N₃

2-Methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride chemical structure, C8H12ClN3, CAS 1159812-70-0

2-Methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

CAS 1159812-70-0C₈H₁₂ClN₃

4-Methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride chemical structure, C8H12ClN3, CAS 1187830-72-3

4-Methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine hydrochloride

CAS 1187830-72-3C₈H₁₂ClN₃

4-Methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine chemical structure, C8H11N3, CAS 1187884-12-3

4-Methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

CAS 1187884-12-3C₈H₁₁N₃

Ethyl 2-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)acetate hydrochloride chemical structure, C11H16ClN3O2, CAS 1187830-52-9

Ethyl 2-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)acetate hydrochloride

CAS 1187830-52-9C₁₁H₁₆ClN₃O₂

Ethyl 2-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)acetate chemical structure, C11H15N3O2, CAS 1187884-08-7

Ethyl 2-(5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)acetate

CAS 1187884-08-7C₁₁H₁₅N₃O₂