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Murcko scaffold

Ring system with 3 rings and 19 atoms

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
12
With full pages
6
Scaffold SMILES

O=C(Nc1nncs1)c1ccc(-c2ccccc2)o1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1nncs1)c1ccc(-c2ccccc2)o1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

5-(3-Chlorophenyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide chemical structure, C15H12ClN3O2S, CAS 6220-87-7
5-(3-Chlorophenyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide
CAS 6220-87-7C15H12ClN3O2S
5-(2-Chlorophenyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide chemical structure, C15H12ClN3O2S, CAS 627042-76-6
5-(2-Chlorophenyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide
CAS 627042-76-6C15H12ClN3O2S
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-5-[3-(trifluoromethyl)phenyl]furan-2-carboxamide chemical structure, C16H12F3N3O2S, CAS 627043-66-7
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-5-[3-(trifluoromethyl)phenyl]furan-2-carboxamide
CAS 627043-66-7C16H12F3N3O2S
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-5-(4-fluorophenyl)furan-2-carboxamide chemical structure, C15H12FN3O2S, CAS 831204-55-8
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-5-(4-fluorophenyl)furan-2-carboxamide
CAS 831204-55-8C15H12FN3O2S
5-(2,5-Dichlorophenyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide chemical structure, C15H11Cl2N3O2S, CAS 425614-06-8
5-(2,5-Dichlorophenyl)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide
CAS 425614-06-8C15H11Cl2N3O2S
N-(5-Methyl-1,3,4-thiadiazol-2-yl)-5-(4-nitrophenyl)furan-2-carboxamide chemical structure, C14H10N4O4S, CAS 627040-99-7
N-(5-Methyl-1,3,4-thiadiazol-2-yl)-5-(4-nitrophenyl)furan-2-carboxamide
CAS 627040-99-7C14H10N4O4S
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-5-[2-(trifluoromethyl)phenyl]furan-2-carboxamide chemical structure, C16H12F3N3O2S, CAS 831214-06-3
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-5-[2-(trifluoromethyl)phenyl]furan-2-carboxamide
CAS 831214-06-3C16H12F3N3O2S
N-(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)-5-(2-fluorophenyl)furan-2-carboxamide chemical structure, C15H12FN3O2S2, CAS 874466-80-5
N-(5-Ethylsulfanyl-1,3,4-thiadiazol-2-yl)-5-(2-fluorophenyl)furan-2-carboxamide
CAS 874466-80-5C15H12FN3O2S2
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-5-(2-fluorophenyl)furan-2-carboxamide chemical structure, C15H12FN3O2S, CAS 876719-00-5
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-5-(2-fluorophenyl)furan-2-carboxamide
CAS 876719-00-5C15H12FN3O2S
5-(3-Nitrophenyl)-N-(5-propyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide chemical structure, C16H14N4O4S, CAS 7061-89-4
5-(3-Nitrophenyl)-N-(5-propyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide
CAS 7061-89-4C16H14N4O4S
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-5-(4-methoxy-2-nitrophenyl)furan-2-carboxamide chemical structure, C16H14N4O5S, CAS 887348-67-6
N-(5-Ethyl-1,3,4-thiadiazol-2-yl)-5-(4-methoxy-2-nitrophenyl)furan-2-carboxamide
CAS 887348-67-6C16H14N4O5S
5-(2-Chlorophenyl)-N-[5-(methoxymethyl)-1,3,4-thiadiazol-2-yl]furan-2-carboxamide chemical structure, C15H12ClN3O3S, CAS 1374531-48-2
5-(2-Chlorophenyl)-N-[5-(methoxymethyl)-1,3,4-thiadiazol-2-yl]furan-2-carboxamide
CAS 1374531-48-2C15H12ClN3O3S