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Murcko scaffold

Ring system with 3 rings and 16 atoms

52 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
52
With full pages
8
Scaffold SMILES

O=C1N=c2ccccc2=C1c1c[nH]c(=S)s1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1N=c2ccccc2=C1c1c[nH]c(=S)s1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 52 chemicals

[(5Z)-4-Oxo-5-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-thioxo-1,3-thiazolidin-3-yl]acetic acid chemical structure, C13H8N2O4S2, CAS 928339-87-1
[(5Z)-4-Oxo-5-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
CAS 928339-87-1C13H8N2O4S2
3-[(5Z)-4-Oxo-5-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid chemical structure, C14H10N2O4S2, CAS 1355339-21-7
3-[(5Z)-4-Oxo-5-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-thioxo-1,3-thiazolidin-3-yl]propanoic acid
CAS 1355339-21-7C14H10N2O4S2
(5Z)-5-(6-Chloro-7-methyl-2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C12H7ClN2O2S2, CAS 362622-47-7
(5Z)-5-(6-Chloro-7-methyl-2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 362622-47-7C12H7ClN2O2S2
(5Z)-5-(5-Methoxy-2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C12H8N2O3S2, CAS 312514-86-6
(5Z)-5-(5-Methoxy-2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 312514-86-6C12H8N2O3S2
3-(3-Allyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-5-bromo-1,3-dihydro-2H-indol-2-one chemical structure, C14H9BrN2O2S2, CAS 309272-91-1
3-(3-Allyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-5-bromo-1,3-dihydro-2H-indol-2-one
CAS 309272-91-1C14H9BrN2O2S2
(5Z)-5-(5-Bromo-2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C11H5BrN2O2S2, CAS 113054-05-0
(5Z)-5-(5-Bromo-2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 113054-05-0C11H5BrN2O2S2
(5E)-5-(2-Hydroxy-3H-indol-3-ylidene)-2-thioxo-1,3-thiazolidin-4-one chemical structure, C11H6N2O2S2, CAS 24704-90-3
(5E)-5-(2-Hydroxy-3H-indol-3-ylidene)-2-thioxo-1,3-thiazolidin-4-one
CAS 24704-90-3C11H6N2O2S2
[(5Z)-5-(5-Methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid chemical structure, C14H10N2O4S2, CAS 113053-99-9
[(5Z)-5-(5-Methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid
CAS 113053-99-9C14H10N2O4S2
(5Z)-5-(5-Methoxy-2-oxo-1H-indol-3-ylidene)-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C15H12N2O3S2, CAS 375832-41-0
(5Z)-5-(5-Methoxy-2-oxo-1H-indol-3-ylidene)-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 375832-41-0C15H12N2O3S2
(5Z)-5-(5-Methyl-2-oxo-1H-indol-3-ylidene)-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C15H12N2O2S2, CAS 375828-61-8
(5Z)-5-(5-Methyl-2-oxo-1H-indol-3-ylidene)-3-prop-2-enyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 375828-61-8C15H12N2O2S2
(5Z)-5-(5-Chloro-2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C11H5ClN2O2S2, CAS 1227046-35-6
(5Z)-5-(5-Chloro-2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 1227046-35-6C11H5ClN2O2S2
(5Z)-5-(5-Ethoxy-2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C13H10N2O3S2, CAS 380563-96-2
(5Z)-5-(5-Ethoxy-2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 380563-96-2C13H10N2O3S2
(Z)-3-Isopropyl-5-(2-oxoindolin-3-ylidene)-2-thioxothiazolidin-4-one chemical structure, C14H12N2O2S2, CAS 324560-87-4
(Z)-3-Isopropyl-5-(2-oxoindolin-3-ylidene)-2-thioxothiazolidin-4-one
CAS 324560-87-4C14H12N2O2S2
(Z)-5-(5-Bromo-2-oxoindolin-3-ylidene)-3-isopropyl-2-thioxothiazolidin-4-one chemical structure, C14H11BrN2O2S2, CAS 324560-88-5
(Z)-5-(5-Bromo-2-oxoindolin-3-ylidene)-3-isopropyl-2-thioxothiazolidin-4-one
CAS 324560-88-5C14H11BrN2O2S2
N-[(5Z)-5-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetamide chemical structure, C13H8BrN3O3S2, CAS 301689-81-6
N-[(5Z)-5-(5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetamide
CAS 301689-81-6C13H8BrN3O3S2
ClpB-IN-1 chemical structure, C14H10N2O2S2, CAS 1453172-23-0
ClpB-IN-1
CAS 1453172-23-0C14H10N2O2S2
(5Z)-5-(5-Bromo-7-methyl-2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C12H7BrN2O2S2, CAS 1380448-60-1
(5Z)-5-(5-Bromo-7-methyl-2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 1380448-60-1C12H7BrN2O2S2
(3Z)-1,3-Dihydro-5-methyl-3-(4-oxo-2-thioxo-5-thiazolidinylidene)-2H-indol-2-one chemical structure, C12H8N2O2S2, CAS 1064366-81-9
(3Z)-1,3-Dihydro-5-methyl-3-(4-oxo-2-thioxo-5-thiazolidinylidene)-2H-indol-2-one
CAS 1064366-81-9C12H8N2O2S2
(5Z)-5-(5,7-Dibromo-2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C11H4Br2N2O2S2, CAS 378199-83-8
(5Z)-5-(5,7-Dibromo-2-oxo-1H-indol-3-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 378199-83-8C11H4Br2N2O2S2
(Z)-5-(5-Bromo-2-oxoindolin-3-ylidene)-3-ethyl-2-thioxothiazolidin-4-one chemical structure, C13H9BrN2O2S2, CAS 354560-89-7
(Z)-5-(5-Bromo-2-oxoindolin-3-ylidene)-3-ethyl-2-thioxothiazolidin-4-one
CAS 354560-89-7C13H9BrN2O2S2
(Z)-4-(4-Oxo-5-(2-oxoindolin-3-ylidene)-2-thioxothiazolidin-3-yl)butanoic acid chemical structure, C15H12N2O4S2, CAS 303798-60-9
(Z)-4-(4-Oxo-5-(2-oxoindolin-3-ylidene)-2-thioxothiazolidin-3-yl)butanoic acid
CAS 303798-60-9C15H12N2O4S2
(5Z)-5-(2-Oxo-1H-indol-3-ylidene)-3-propyl-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C14H12N2O2S2, CAS 381694-19-5
(5Z)-5-(2-Oxo-1H-indol-3-ylidene)-3-propyl-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 381694-19-5C14H12N2O2S2
(3Z)-3-(3-Isobutyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one chemical structure, C15H14N2O2S2, CAS 438458-81-2
(3Z)-3-(3-Isobutyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)-1,3-dihydro-2H-indol-2-one
CAS 438458-81-2C15H14N2O2S2
(Z)-N-(4-Oxo-5-(2-oxoindolin-3-ylidene)-2-thioxothiazolidin-3-yl)octanamide chemical structure, C19H21N3O3S2, CAS 300819-10-7
(Z)-N-(4-Oxo-5-(2-oxoindolin-3-ylidene)-2-thioxothiazolidin-3-yl)octanamide
CAS 300819-10-7C19H21N3O3S2