Murcko scaffold
Ring system with 2 rings and 19 atoms
58 chemicals on CompoundList share this ring system.
- Rings
- 2
- Scaffold atoms
- 19
- Chemicals
- 58
- With full pages
- 11
Scaffold SMILES
O=C(COC(=O)c1ccccn1)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 58 chemicals
![[2-(3-Acetylanilino)-2-oxoethyl] pyridine-2-carboxylate chemical structure, C16H14N2O4, CAS 386730-06-9](/s/YBELQQVRJWXMNH-UHFFFAOYSA-N.svg)
[2-(3-Acetylanilino)-2-oxoethyl] pyridine-2-carboxylate
CAS 386730-06-9C16H14N2O4
Pyridine-2-carboxylic acid m-tolylcarbamoyl-methyl ester
CAS 386730-16-1C15H14N2O3
![[(2,6-Diethylphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate chemical structure, C18H18Cl2N2O3, CAS 743464-57-5](/s/MJKPAOVXIUOMDC-UHFFFAOYSA-N.svg)
[(2,6-Diethylphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate
CAS 743464-57-5C18H18Cl2N2O3
![[(5-Chloro-2-cyanophenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate chemical structure, C15H8Cl3N3O3, CAS 744229-45-6](/s/GUAHJHYOBDRGBO-UHFFFAOYSA-N.svg)
[(5-Chloro-2-cyanophenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate
CAS 744229-45-6C15H8Cl3N3O3
![[(4-Cyanophenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate chemical structure, C15H9Cl2N3O3, CAS 745025-08-5](/s/LXBSWOPRYDYBIQ-UHFFFAOYSA-N.svg)
[(4-Cyanophenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate
CAS 745025-08-5C15H9Cl2N3O3
![[(4-Acetylphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate chemical structure, C16H12Cl2N2O4, CAS 749219-76-9](/s/SZECHBZENLEXHA-UHFFFAOYSA-N.svg)
[(4-Acetylphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate
CAS 749219-76-9C16H12Cl2N2O4
![[(3-Methoxyphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate chemical structure, C15H12Cl2N2O4, CAS 749221-47-4](/s/PVTWIZWUENBORF-UHFFFAOYSA-N.svg)
[(3-Methoxyphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate
CAS 749221-47-4C15H12Cl2N2O4
![[2-(3,5-Dichloroanilino)-2-oxoethyl] 3,6-dichloropyridine-2-carboxylate chemical structure, C14H8Cl4N2O3, CAS 721418-03-7](/s/KCHMGUIRPCNQME-UHFFFAOYSA-N.svg)
[2-(3,5-Dichloroanilino)-2-oxoethyl] 3,6-dichloropyridine-2-carboxylate
CAS 721418-03-7C14H8Cl4N2O3
![[2-(3-Chloro-4-methylanilino)-2-oxoethyl] 3,4,5,6-tetrachloropyridine-2-carboxylate chemical structure, C15H9Cl5N2O3, CAS 522640-56-8](/s/KMMGYJYIGXMSQY-UHFFFAOYSA-N.svg)
[2-(3-Chloro-4-methylanilino)-2-oxoethyl] 3,4,5,6-tetrachloropyridine-2-carboxylate
CAS 522640-56-8C15H9Cl5N2O3
![[(3-Acetylphenyl)carbamoyl]methyl 3,4,5,6-tetrachloropyridine-2-carboxylate chemical structure, C16H10Cl4N2O4, CAS 522640-79-5](/s/CTSZFCKQFUKGSJ-UHFFFAOYSA-N.svg)
[(3-Acetylphenyl)carbamoyl]methyl 3,4,5,6-tetrachloropyridine-2-carboxylate
CAS 522640-79-5C16H10Cl4N2O4
![{[2-(Difluoromethoxy)phenyl]carbamoyl}methyl 3,6-dichloropyridine-2-carboxylate chemical structure, C15H10Cl2F2N2O4, CAS 737819-33-9](/s/QNCRDDZXTRNZHK-UHFFFAOYSA-N.svg)
{[2-(Difluoromethoxy)phenyl]carbamoyl}methyl 3,6-dichloropyridine-2-carboxylate
CAS 737819-33-9C15H10Cl2F2N2O4
![{[4-(Propan-2-yl)phenyl]carbamoyl}methyl 3,6-dichloropyridine-2-carboxylate chemical structure, C17H16Cl2N2O3, CAS 722470-42-0](/s/CMVLWYXQYHBLTL-UHFFFAOYSA-N.svg)
{[4-(Propan-2-yl)phenyl]carbamoyl}methyl 3,6-dichloropyridine-2-carboxylate
CAS 722470-42-0C17H16Cl2N2O3
![[(2,5-Dimethoxyphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate chemical structure, C16H14Cl2N2O5, CAS 722471-08-1](/s/HJOZHMKJAXCZKE-UHFFFAOYSA-N.svg)
[(2,5-Dimethoxyphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate
CAS 722471-08-1C16H14Cl2N2O5
![[(2-Cyanophenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate chemical structure, C15H9Cl2N3O3, CAS 722471-11-6](/s/ZNADWVSYPOUGTJ-UHFFFAOYSA-N.svg)
[(2-Cyanophenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate
CAS 722471-11-6C15H9Cl2N3O3
![{[4-(Difluoromethoxy)phenyl]carbamoyl}methyl 3,6-dichloropyridine-2-carboxylate chemical structure, C15H10Cl2F2N2O4, CAS 730247-25-3](/s/LGIDYHRXKNAFNB-UHFFFAOYSA-N.svg)
{[4-(Difluoromethoxy)phenyl]carbamoyl}methyl 3,6-dichloropyridine-2-carboxylate
CAS 730247-25-3C15H10Cl2F2N2O4
![[(3-Cyanophenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate chemical structure, C15H9Cl2N3O3, CAS 728926-71-4](/s/YDYFMUQSJWYZLN-UHFFFAOYSA-N.svg)
[(3-Cyanophenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate
CAS 728926-71-4C15H9Cl2N3O3
![[(3-Fluoro-4-methylphenyl)carbamoyl]methyl pyridine-2-carboxylate chemical structure, C15H13FN2O3, CAS 733786-38-4](/s/JUADFGMXNLYHKY-UHFFFAOYSA-N.svg)
[(3-Fluoro-4-methylphenyl)carbamoyl]methyl pyridine-2-carboxylate
CAS 733786-38-4C15H13FN2O3
![[(3-Fluoro-4-methylphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate chemical structure, C15H11Cl2FN2O3, CAS 849128-01-4](/s/AJEORINGRDPZJB-UHFFFAOYSA-N.svg)
[(3-Fluoro-4-methylphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate
CAS 849128-01-4C15H11Cl2FN2O3
![[(3-Chloro-4-cyanophenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate chemical structure, C15H8Cl3N3O3, CAS 848321-15-3](/s/WPAHCYMPNCUKLH-UHFFFAOYSA-N.svg)
[(3-Chloro-4-cyanophenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate
CAS 848321-15-3C15H8Cl3N3O3
![[2-(2,3-Dimethylanilino)-2-oxoethyl] 3,6-dichloropyridine-2-carboxylate chemical structure, C16H14Cl2N2O3, CAS 848228-59-1](/s/JKMVBFGMMNXXMV-UHFFFAOYSA-N.svg)
[2-(2,3-Dimethylanilino)-2-oxoethyl] 3,6-dichloropyridine-2-carboxylate
CAS 848228-59-1C16H14Cl2N2O3
![[(3-Methylphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate chemical structure, C15H12Cl2N2O3, CAS 930685-67-9](/s/CLAXAYYAFJCFHL-UHFFFAOYSA-N.svg)
[(3-Methylphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate
CAS 930685-67-9C15H12Cl2N2O3
![[(2-Methoxy-5-methylphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate chemical structure, C16H14Cl2N2O4, CAS 848321-08-4](/s/LLOSXPADOQTSPB-UHFFFAOYSA-N.svg)
[(2-Methoxy-5-methylphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate
CAS 848321-08-4C16H14Cl2N2O4
![[(3-Bromophenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate chemical structure, C14H9BrCl2N2O3, CAS 848321-01-7](/s/DOYBOENFCHUMCD-UHFFFAOYSA-N.svg)
[(3-Bromophenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate
CAS 848321-01-7C14H9BrCl2N2O3
![[(2-Methylphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate chemical structure, C15H12Cl2N2O3, CAS 930960-36-4](/s/AYYXAOOVUSGCHB-UHFFFAOYSA-N.svg)
[(2-Methylphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate
CAS 930960-36-4C15H12Cl2N2O3
- [(2-Ethoxyphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate848228-65-9C16H14Cl2N2O4
- (Phenylcarbamoyl)methyl 3,6-dichloropyridine-2-carboxylate848321-10-8C14H10Cl2N2O3
- [(3-Chlorophenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate848228-61-5C14H9Cl3N2O3
- [(2-Methoxyphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate848320-98-9C15H12Cl2N2O4
- [(4-Chlorophenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate872193-77-6C14H9Cl3N2O3
- [(3,4-Dimethoxyphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate874753-04-5C16H14Cl2N2O5
- [(2-Cyanoethyl)(4-methylphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate924123-56-8C18H15Cl2N3O3
- [2-(N-Methylanilino)-2-oxoethyl] 3,6-dichloropyridine-2-carboxylate1090886-20-6C15H12Cl2N2O3
- [2-[N-(2-Cyanoethyl)anilino]-2-oxoethyl] 3,6-dichloropyridine-2-carboxylate1003727-99-8C17H13Cl2N3O3
- 2-{[4-Chloro-3-(ethoxycarbonyl)phenyl]amino}-2-oxoethyl pyridine-2-carboxylate842972-20-7C17H15ClN2O5
- [2-(4-Fluoro-2-nitroanilino)-2-oxoethyl] 3,6-dichloropyridine-2-carboxylate874593-68-7C14H8Cl2FN3O5
- [(2,4,5-Trichlorophenyl)carbamoyl]methyl 3,4,5,6-tetrachloropyridine-2-carboxylate877250-96-9C14H5Cl7N2O3
- {[2-Chloro-5-(trifluoromethyl)phenyl]carbamoyl}methyl 3,6-dichloropyridine-2-carboxylate721912-91-0C15H8Cl3F3N2O3
- [(4-Carbamoylphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate743455-69-8C15H11Cl2N3O4
- [2-(2,4-Difluoroanilino)-2-oxoethyl] 3,6-dichloropyridine-2-carboxylate1003966-79-7C14H8Cl2F2N2O3
- [(4-Methoxy-2-nitrophenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate721912-87-4C15H11Cl2N3O6
- {[4-Chloro-3-(dimethylsulfamoyl)phenyl]carbamoyl}methyl 3,6-dichloropyridine-2-carboxylate733029-64-6C16H14Cl3N3O5S
- {[5-(Diethylsulfamoyl)-2-methylphenyl]carbamoyl}methyl 3,6-dichloropyridine-2-carboxylate848595-74-4C19H21Cl2N3O5S
- [(2,5-Dimethylphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate848895-67-0C16H14Cl2N2O3
- ({2-[(Cyanomethyl)sulfanyl]phenyl}carbamoyl)methyl 3,6-dichloropyridine-2-carboxylate852685-54-2C16H11Cl2N3O3S
- [(3-Sulfamoylphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate852828-31-0C14H11Cl2N3O5S
- {[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}methyl 3,6-dichloropyridine-2-carboxylate848659-24-5C15H8Cl3F3N2O3
- [(3-Chloro-2-methylphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate848291-99-6C15H11Cl3N2O3
- [(4-Bromo-3-methylphenyl)carbamoyl]methyl 3,6-dichloropyridine-2-carboxylate848321-07-3C15H11BrCl2N2O3
Related scaffolds
Same ring framework with different atoms or bond orders
S=C(NN=Cc1ccccc1)Nc1ccccc1105 chemicals
S=C(NCCc1ccccc1)Nc1ccccc160 chemicals
c1ccc(CCNCCc2ccccc2)cc158 chemicals
O=C(COc1ccccc1)NCc1ccccc146 chemicals
O=C(NCCOc1ccccc1)c1ccccc146 chemicals
O=C(C=Cc1ccccc1)NCc1ccccc143 chemicals
c1ccc(OCCCOc2ccccc2)cc141 chemicals
O=C(CC(=O)Nc1ccccc1)Nc1ccccc137 chemicals
O=C(CNS(=O)(=O)c1ccccc1)Nc1ccccc136 chemicals
O=C(CSCc1ccccc1)Nc1ccccc133 chemicals
O=C(Cc1ccccc1)NCCc1ccccc132 chemicals
O=C(CNCc1ccccc1)Nc1ccccc131 chemicals