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Murcko scaffold

Ring system with 3 rings and 20 atoms

10 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
20
Chemicals
10
With full pages
4
Scaffold SMILES

O=C(CN1CCCCC1)c1ccn(-c2ccccc2)c1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CN1CCCCC1)c1ccn(-c2ccccc2)c1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 10 of 10 chemicals

1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(piperidin-1-yl)ethan-1-one chemical structure, C19H23FN2O, CAS 670268-20-9
1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(piperidin-1-yl)ethan-1-one
CAS 670268-20-9C19H23FN2O
1-[1-(4-Fluorophenyl)-2,5-dimethyl-3-pyrrolyl]-2-(4-methyl-1-piperidinyl)ethanone chemical structure, C20H25FN2O, CAS 325742-01-6
1-[1-(4-Fluorophenyl)-2,5-dimethyl-3-pyrrolyl]-2-(4-methyl-1-piperidinyl)ethanone
CAS 325742-01-6C20H25FN2O
1-(1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethanone chemical structure, C19H23ClN2O, CAS 670270-31-2
1-(1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethanone
CAS 670270-31-2C19H23ClN2O
1-[1-(4-Methoxyphenyl)-2,5-dimethylpyrrol-3-yl]-2-piperidin-1-ylethanone chemical structure, C20H26N2O2, CAS 379250-49-4
1-[1-(4-Methoxyphenyl)-2,5-dimethylpyrrol-3-yl]-2-piperidin-1-ylethanone
CAS 379250-49-4C20H26N2O2
1-[1-[4-Chloro-3-(trifluoromethyl)phenyl]-2,5-dimethylpyrrol-3-yl]-2-(4-methylpiperidin-1-yl)ethanone chemical structure, C21H24ClF3N2O, CAS 315707-65-4
1-[1-[4-Chloro-3-(trifluoromethyl)phenyl]-2,5-dimethylpyrrol-3-yl]-2-(4-methylpiperidin-1-yl)ethanone
CAS 315707-65-4C21H24ClF3N2O
1-[1-(3,4-Dichlorophenyl)-2,5-dimethylpyrrol-3-yl]-2-piperidin-1-ylethanone chemical structure, C19H22Cl2N2O, CAS 379238-57-0
1-[1-(3,4-Dichlorophenyl)-2,5-dimethylpyrrol-3-yl]-2-piperidin-1-ylethanone
CAS 379238-57-0C19H22Cl2N2O
1-(1-(3-Chloro-4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethanone chemical structure, C19H22ClFN2O, CAS 670270-57-2
1-(1-(3-Chloro-4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1-yl)ethanone
CAS 670270-57-2C19H22ClFN2O
1-[1-(4-Ethoxyphenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(4-methylpiperidin-1-yl)ethan-1-one chemical structure, C22H30N2O2, CAS 315676-35-8
1-[1-(4-Ethoxyphenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(4-methylpiperidin-1-yl)ethan-1-one
CAS 315676-35-8C22H30N2O2
Diethyl 5-(2,5-dimethyl-3-(2-(4-methylpiperidin-1-yl)acetyl)-1H-pyrrol-1-yl)isophthalate chemical structure, C26H34N2O5, CAS 379249-53-3
Diethyl 5-(2,5-dimethyl-3-(2-(4-methylpiperidin-1-yl)acetyl)-1H-pyrrol-1-yl)isophthalate
CAS 379249-53-3C26H34N2O5
4-(3-(2-(4-Hydroxypiperidin-1-yl)acetyl)-2,5-dimethyl-1H-pyrrol-1-yl)benzonitrile chemical structure, C20H23N3O2, CAS 2307472-03-1
4-(3-(2-(4-Hydroxypiperidin-1-yl)acetyl)-2,5-dimethyl-1H-pyrrol-1-yl)benzonitrile
CAS 2307472-03-1C20H23N3O2