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Murcko scaffold

2,6-Diphenylpyrimidin-4-ol scaffold

24 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
24
With full pages
6
Scaffold SMILES

O=c1cc(-c2ccccc2)nc(-c2ccccc2)[nH]1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 2,6-Diphenylpyrimidin-4-ol page
Murcko scaffold O=c1cc(-c2ccccc2)nc(-c2ccccc2)[nH]1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 24 of 24 chemicals

5-Methyl-2,6-diphenyl-4-pyrimidinol chemical structure, C17H14N2O, CAS 10488-96-7
5-Methyl-2,6-diphenyl-4-pyrimidinol
CAS 10488-96-7C17H14N2O
4-Hydroxy-2,6-diphenyl-5-pyrimidinecarbonitrile chemical structure, C17H11N3O, CAS 737-54-2
4-Hydroxy-2,6-diphenyl-5-pyrimidinecarbonitrile
CAS 737-54-2C17H11N3O
4-(4-Fluorophenyl)-6-hydroxy-2-phenylpyrimidine-5-carbonitrile chemical structure, C17H10FN3O, CAS 477853-95-5
4-(4-Fluorophenyl)-6-hydroxy-2-phenylpyrimidine-5-carbonitrile
CAS 477853-95-5C17H10FN3O
4-Hydroxy-6-(2-methoxyphenyl)-2-phenyl-5-pyrimidinecarbonitrile chemical structure, C18H13N3O2, CAS 477853-96-6
4-Hydroxy-6-(2-methoxyphenyl)-2-phenyl-5-pyrimidinecarbonitrile
CAS 477853-96-6C18H13N3O2
2,6-Diphenylpyrimidin-4-ol chemical structure, C16H12N2O, CAS 15969-46-7
2,6-Diphenylpyrimidin-4-ol
CAS 15969-46-7C16H12N2O
4-Hydroxy-6-(3-methoxyphenyl)-2-phenyl-5-pyrimidinecarbonitrile chemical structure, C18H13N3O2, CAS 338982-08-4
4-Hydroxy-6-(3-methoxyphenyl)-2-phenyl-5-pyrimidinecarbonitrile
CAS 338982-08-4C18H13N3O2
4-Hydroxy-6-(4-methylphenyl)-2-phenyl-5-pyrimidinecarbonitrile chemical structure, C18H13N3O, CAS 477853-90-0
4-Hydroxy-6-(4-methylphenyl)-2-phenyl-5-pyrimidinecarbonitrile
CAS 477853-90-0C18H13N3O
4-Hydroxy-6-(4-methoxyphenyl)-2-(3-methylphenyl)-5-pyrimidinecarbonitrile chemical structure, C19H15N3O2, CAS 477859-02-2
4-Hydroxy-6-(4-methoxyphenyl)-2-(3-methylphenyl)-5-pyrimidinecarbonitrile
CAS 477859-02-2C19H15N3O2
4-Hydroxy-6-(4-methoxyphenyl)-2-phenyl-5-pyrimidinecarbonitrile chemical structure, C18H13N3O2, CAS 89058-98-0
4-Hydroxy-6-(4-methoxyphenyl)-2-phenyl-5-pyrimidinecarbonitrile
CAS 89058-98-0C18H13N3O2
6-(4-Nitrophenyl)-4-oxo-2-phenyl-1,4-dihydropyrimidine-5-carbonitrile chemical structure, C17H10N4O3, CAS 89058-99-1
6-(4-Nitrophenyl)-4-oxo-2-phenyl-1,4-dihydropyrimidine-5-carbonitrile
CAS 89058-99-1C17H10N4O3
2-(2-Chlorophenyl)-6-(4-hydroxy-3-methylphenyl)pyrimidin-4(3H)-one chemical structure, C17H13ClN2O2, CAS 1076188-16-3
2-(2-Chlorophenyl)-6-(4-hydroxy-3-methylphenyl)pyrimidin-4(3H)-one
CAS 1076188-16-3C17H13ClN2O2
2-(4-Oxocyclohexa-2,5-dien-1-ylidene)-6-phenyl-2,3-dihydropyrimidin-4(1H)-one chemical structure, C16H12N2O2, CAS 651719-94-7
2-(4-Oxocyclohexa-2,5-dien-1-ylidene)-6-phenyl-2,3-dihydropyrimidin-4(1H)-one
CAS 651719-94-7C16H12N2O2
4-[4-(4-Oxo-6-phenyl-1,4-dihydropyrimidin-2-yl)phenoxy]butanoic acid chemical structure, C20H18N2O4, CAS 651720-12-6
4-[4-(4-Oxo-6-phenyl-1,4-dihydropyrimidin-2-yl)phenoxy]butanoic acid
CAS 651720-12-6C20H18N2O4
[4-(4-Oxo-6-phenyl-1,4-dihydropyrimidin-2-yl)phenoxy]acetic acid chemical structure, C18H14N2O4, CAS 651720-03-5
[4-(4-Oxo-6-phenyl-1,4-dihydropyrimidin-2-yl)phenoxy]acetic acid
CAS 651720-03-5C18H14N2O4
Ethyl 4-(2,4-dichlorophenyl)-6-oxo-2-phenyl-1,6-dihydropyrimidine-5-carboxylate chemical structure, C19H14Cl2N2O3, CAS 895151-61-8
Ethyl 4-(2,4-dichlorophenyl)-6-oxo-2-phenyl-1,6-dihydropyrimidine-5-carboxylate
CAS 895151-61-8C19H14Cl2N2O3
2-(4-Aminophenyl)-4-phenyl-1H-pyrimidin-6-one chemical structure, C16H13N3O, CAS 1498585-41-3
2-(4-Aminophenyl)-4-phenyl-1H-pyrimidin-6-one
CAS 1498585-41-3C16H13N3O
5-Bromo-2-(4-bromophenyl)-6-phenyl-4(3H)-pyrimidinone chemical structure, C16H10Br2N2O, CAS 338734-67-1
5-Bromo-2-(4-bromophenyl)-6-phenyl-4(3H)-pyrimidinone
CAS 338734-67-1C16H10Br2N2O
5-Acetyl-2,6-diphenylpyrimidin-4(1H)-one chemical structure, C18H14N2O2, CAS 20954-87-4
5-Acetyl-2,6-diphenylpyrimidin-4(1H)-one
CAS 20954-87-4C18H14N2O2
4(1H)-Pyrimidinone,2-(4-chlorophenyl)-6-(2-methylphenyl)- chemical structure, C17H13ClN2O, CAS 141650-68-2
4(1H)-Pyrimidinone,2-(4-chlorophenyl)-6-(2-methylphenyl)-
CAS 141650-68-2C17H13ClN2O
2-(2-Ethoxyphenyl)-6-phenyl-4(3H)-pyrimidinone chemical structure, C18H16N2O2, CAS 1229020-06-7
2-(2-Ethoxyphenyl)-6-phenyl-4(3H)-pyrimidinone
CAS 1229020-06-7C18H16N2O2
6-(4-Chlorophenyl)-2-phenyl-4(3H)-pyrimidinone chemical structure, C16H11ClN2O, CAS 83501-11-5
6-(4-Chlorophenyl)-2-phenyl-4(3H)-pyrimidinone
CAS 83501-11-5C16H11ClN2O
4-(2,4-Dichlorophenyl)-2-phenyl-1H-pyrimidin-6-one chemical structure, C16H10Cl2N2O, CAS 1616398-60-7
4-(2,4-Dichlorophenyl)-2-phenyl-1H-pyrimidin-6-one
CAS 1616398-60-7C16H10Cl2N2O
4-(4-Methylphenyl)-2-phenyl-1H-pyrimidin-6-one chemical structure, C17H14N2O, CAS 77232-15-6
4-(4-Methylphenyl)-2-phenyl-1H-pyrimidin-6-one
CAS 77232-15-6C17H14N2O
4-(3-Methoxyphenyl)-2-phenyl-1H-pyrimidin-6-one chemical structure, C17H14N2O2, CAS 1284901-46-7
4-(3-Methoxyphenyl)-2-phenyl-1H-pyrimidin-6-one
CAS 1284901-46-7C17H14N2O2