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Murcko scaffold

Ring system with 3 rings and 19 atoms

19 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
19
With full pages
14
Scaffold SMILES

O=c1ncn(-c2ccccc2)cc1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=c1ncn(-c2ccccc2)cc1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 19 of 19 chemicals

1-(2-Hydroxyphenyl)-2,6-dimethyl-5-phenylpyrimidin-4-one chemical structure, C18H16N2O2, CAS 122664-41-9
1-(2-Hydroxyphenyl)-2,6-dimethyl-5-phenylpyrimidin-4-one
CAS 122664-41-9C18H16N2O2
3-(2,6-Dimethyl-4-oxo-5-phenylpyrimidin-1-yl)benzoic acid chemical structure, C19H16N2O3, CAS 225222-09-3
3-(2,6-Dimethyl-4-oxo-5-phenylpyrimidin-1-yl)benzoic acid
CAS 225222-09-3C19H16N2O3
N-[4-(2,6-Dimethyl-4-oxo-5-phenylpyrimidin-1-yl)phenyl]acetamide chemical structure, C20H19N3O2, CAS 418778-55-9
N-[4-(2,6-Dimethyl-4-oxo-5-phenylpyrimidin-1-yl)phenyl]acetamide
CAS 418778-55-9C20H19N3O2
1-(2-Methoxyphenyl)-2,6-dimethyl-5-phenylpyrimidin-4-one chemical structure, C19H18N2O2, CAS 225222-41-3
1-(2-Methoxyphenyl)-2,6-dimethyl-5-phenylpyrimidin-4-one
CAS 225222-41-3C19H18N2O2
2-(2,6-Dimethyl-4-oxo-5-phenylpyrimidin-1-yl)benzoic acid chemical structure, C19H16N2O3, CAS 225222-07-1
2-(2,6-Dimethyl-4-oxo-5-phenylpyrimidin-1-yl)benzoic acid
CAS 225222-07-1C19H16N2O3
1-(2,4-Dichlorophenyl)-2,6-dimethyl-5-phenylpyrimidin-4-one chemical structure, C18H14Cl2N2O, CAS 334498-06-5
1-(2,4-Dichlorophenyl)-2,6-dimethyl-5-phenylpyrimidin-4-one
CAS 334498-06-5C18H14Cl2N2O
2,6-Dimethyl-1,5-diphenyl-4(1H)-pyrimidinone chemical structure, C18H16N2O, CAS 159180-93-5
2,6-Dimethyl-1,5-diphenyl-4(1H)-pyrimidinone
CAS 159180-93-5C18H16N2O
4-(2,6-Dimethyl-4-oxo-5-phenylpyrimidin-1(4H)-yl)benzoic acid chemical structure, C19H16N2O3, CAS 225222-11-7
4-(2,6-Dimethyl-4-oxo-5-phenylpyrimidin-1(4H)-yl)benzoic acid
CAS 225222-11-7C19H16N2O3
(E)-3-(3-(2,6-Dimethyl-4-oxo-5-phenylpyrimidin-1(4H)-yl)phenyl)acrylic acid chemical structure, C21H18N2O3, CAS 375361-11-8
(E)-3-(3-(2,6-Dimethyl-4-oxo-5-phenylpyrimidin-1(4H)-yl)phenyl)acrylic acid
CAS 375361-11-8C21H18N2O3
1-(4-Methoxyphenyl)-2,6-dimethyl-5-phenylpyrimidin-4-one chemical structure, C19H18N2O2, CAS 188898-46-6
1-(4-Methoxyphenyl)-2,6-dimethyl-5-phenylpyrimidin-4-one
CAS 188898-46-6C19H18N2O2
1-(4-Hydroxyphenyl)-2,6-dimethyl-5-phenylpyrimidin-4-one chemical structure, C18H16N2O2, CAS 122664-43-1
1-(4-Hydroxyphenyl)-2,6-dimethyl-5-phenylpyrimidin-4-one
CAS 122664-43-1C18H16N2O2
2,6-Dimethyl-1-(4-methylphenyl)-5-phenylpyrimidin-4-one chemical structure, C19H18N2O, CAS 331967-53-4
2,6-Dimethyl-1-(4-methylphenyl)-5-phenylpyrimidin-4-one
CAS 331967-53-4C19H18N2O
[2-(2,6-Dimethyl-4-oxo-5-phenylpyrimidin-1-yl)phenyl] acetate chemical structure, C20H18N2O3, CAS 122664-44-2
[2-(2,6-Dimethyl-4-oxo-5-phenylpyrimidin-1-yl)phenyl] acetate
CAS 122664-44-2C20H18N2O3
4-(2,6-Dimethyl-4-oxo-5-phenylpyrimidin-1-yl)-2-hydroxybenzoic acid chemical structure, C19H16N2O4, CAS 425607-55-2
4-(2,6-Dimethyl-4-oxo-5-phenylpyrimidin-1-yl)-2-hydroxybenzoic acid
CAS 425607-55-2C19H16N2O4
5-(2,6-Dimethyl-4-oxo-5-phenylpyrimidin-1(4H)-yl)-2-hydroxybenzoic acid chemical structure, C19H16N2O4, CAS 438622-84-5
5-(2,6-Dimethyl-4-oxo-5-phenylpyrimidin-1(4H)-yl)-2-hydroxybenzoic acid
CAS 438622-84-5C19H16N2O4
2,6-Dimethyl-1-(2-methyl-5-nitrophenyl)-5-phenylpyrimidin-4-one chemical structure, C19H17N3O3, CAS 372154-69-3
2,6-Dimethyl-1-(2-methyl-5-nitrophenyl)-5-phenylpyrimidin-4-one
CAS 372154-69-3C19H17N3O3
1-(4-Bromophenyl)-2,6-dimethyl-5-phenyl-4(1H)-pyrimidinone chemical structure, C18H15BrN2O, CAS 302812-34-6
1-(4-Bromophenyl)-2,6-dimethyl-5-phenyl-4(1H)-pyrimidinone
CAS 302812-34-6C18H15BrN2O
[4-(2,6-Dimethyl-4-oxo-5-phenylpyrimidin-1(4H)-yl)phenoxy]acetic acid chemical structure, C20H18N2O4, CAS 425417-59-0
[4-(2,6-Dimethyl-4-oxo-5-phenylpyrimidin-1(4H)-yl)phenoxy]acetic acid
CAS 425417-59-0C20H18N2O4
1-(4-Iodo-2-methylphenyl)-2,6-dimethyl-5-phenyl-4(1H)-pyrimidinone chemical structure, C19H17IN2O, CAS 732249-80-8
1-(4-Iodo-2-methylphenyl)-2,6-dimethyl-5-phenyl-4(1H)-pyrimidinone
CAS 732249-80-8C19H17IN2O