CompoundList
Sign in
Murcko scaffold

Ring system with 3 rings and 19 atoms

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
12
With full pages
8
Scaffold SMILES

O=C1CC(c2ccccc2)N=C(c2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C1CC(c2ccccc2)N=C(c2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

Ethyl 6-hydroxy-2,4-diphenyl-4,5-dihydro-5-pyrimidinecarboxylate chemical structure, C19H18N2O3, CAS 226954-82-1
Ethyl 6-hydroxy-2,4-diphenyl-4,5-dihydro-5-pyrimidinecarboxylate
CAS 226954-82-1C19H18N2O3
Ethyl 4-(4-chlorophenyl)-6-hydroxy-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate chemical structure, C19H17ClN2O3, CAS 400078-28-6
Ethyl 4-(4-chlorophenyl)-6-hydroxy-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate
CAS 400078-28-6C19H17ClN2O3
Ethyl 4-(2-chloro-6-fluorophenyl)-6-hydroxy-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate chemical structure, C19H16ClFN2O3, CAS 477867-24-6
Ethyl 4-(2-chloro-6-fluorophenyl)-6-hydroxy-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate
CAS 477867-24-6C19H16ClFN2O3
Ethyl 6-hydroxy-2-phenyl-4-[4-(trifluoromethyl)phenyl]-4,5-dihydro-5-pyrimidinecarboxylate chemical structure, C20H17F3N2O3, CAS 477867-28-0
Ethyl 6-hydroxy-2-phenyl-4-[4-(trifluoromethyl)phenyl]-4,5-dihydro-5-pyrimidinecarboxylate
CAS 477867-28-0C20H17F3N2O3
Ethyl 4-(4-fluorophenyl)-6-hydroxy-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate chemical structure, C19H17FN2O3, CAS 477867-27-9
Ethyl 4-(4-fluorophenyl)-6-hydroxy-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate
CAS 477867-27-9C19H17FN2O3
Ethyl 6-hydroxy-4-(4-methoxyphenyl)-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate chemical structure, C20H20N2O4, CAS 400078-30-0
Ethyl 6-hydroxy-4-(4-methoxyphenyl)-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate
CAS 400078-30-0C20H20N2O4
Ethyl 6-hydroxy-4-(4-methylphenyl)-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate chemical structure, C20H20N2O3, CAS 400078-29-7
Ethyl 6-hydroxy-4-(4-methylphenyl)-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate
CAS 400078-29-7C20H20N2O3
Ethyl 6-hydroxy-4-(4-isopropylphenyl)-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate chemical structure, C22H24N2O3, CAS 477867-17-7
Ethyl 6-hydroxy-4-(4-isopropylphenyl)-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate
CAS 477867-17-7C22H24N2O3
Ethyl 6-hydroxy-4-(4-hydroxy-3-methoxyphenyl)-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate chemical structure, C20H20N2O5, CAS 400078-32-2
Ethyl 6-hydroxy-4-(4-hydroxy-3-methoxyphenyl)-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate
CAS 400078-32-2C20H20N2O5
Ethyl 4-(4-bromophenyl)-6-hydroxy-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate chemical structure, C19H17BrN2O3, CAS 477867-22-4
Ethyl 4-(4-bromophenyl)-6-hydroxy-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate
CAS 477867-22-4C19H17BrN2O3
Ethyl 4-(3-bromophenyl)-6-hydroxy-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate chemical structure, C19H17BrN2O3, CAS 400078-27-5
Ethyl 4-(3-bromophenyl)-6-hydroxy-2-phenyl-4,5-dihydro-5-pyrimidinecarboxylate
CAS 400078-27-5C19H17BrN2O3
6-Phenyl-2-(3,4,5-trimethoxyphenyl)-5,6-dihydropyrimidin-4(3H)-one chemical structure, C19H20N2O4, CAS 61167-39-3
6-Phenyl-2-(3,4,5-trimethoxyphenyl)-5,6-dihydropyrimidin-4(3H)-one
CAS 61167-39-3C19H20N2O4