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Murcko scaffold

Pyrimidine, 2,4-diphenyl- scaffold

176 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
18
Chemicals
176
With full pages
34
Scaffold SMILES

c1ccc(-c2ccnc(-c3ccccc3)n2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Pyrimidine, 2,4-diphenyl- page
Murcko scaffold c1ccc(-c2ccnc(-c3ccccc3)n2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 176 chemicals

2,4-Bis(3'((2''-(dimethylamino)ethyl)thio)phenyl)pyrimidine chemical structure, C24H30N4S2, CAS 129225-01-0
2,4-Bis(3'((2''-(dimethylamino)ethyl)thio)phenyl)pyrimidine
CAS 129225-01-0C24H30N4S2
Ethanamine, 2,2'-(2,4-pyrimidinediylbis(3,1-phenylenethio))bis(N,N-dimethyl-, trihydrobromide chemical structure, C24H33Br3N4S2, CAS 144085-64-3
Ethanamine, 2,2'-(2,4-pyrimidinediylbis(3,1-phenylenethio))bis(N,N-dimethyl-, trihydrobromide
CAS 144085-64-3C24H33Br3N4S2
4-Chloro-2,6-diphenylpyrimidine chemical structure, C16H11ClN2, CAS 29509-91-9
4-Chloro-2,6-diphenylpyrimidine
CAS 29509-91-9C16H11ClN2
4-Amino-2,6-diphenylpyrimidine chemical structure, C16H13N3, CAS 41270-99-9
4-Amino-2,6-diphenylpyrimidine
CAS 41270-99-9C16H13N3
4-Phenyl-2-(2-hydroxyphenyl)pyrimidine chemical structure, C16H12N2O, CAS 65644-26-0
4-Phenyl-2-(2-hydroxyphenyl)pyrimidine
CAS 65644-26-0C16H12N2O
2-(4-Fluorophenyl)-4-phenylpyrimidine chemical structure, C16H11FN2, CAS 76128-69-3
2-(4-Fluorophenyl)-4-phenylpyrimidine
CAS 76128-69-3C16H11FN2
2-(3-Fluorophenyl)-4-phenylpyrimidine chemical structure, C16H11FN2, CAS 76128-68-2
2-(3-Fluorophenyl)-4-phenylpyrimidine
CAS 76128-68-2C16H11FN2
4,4'-Pyrimidine-2,4-diyldianiline chemical structure, C16H14N4, CAS 85489-56-1
4,4'-Pyrimidine-2,4-diyldianiline
CAS 85489-56-1C16H14N4
2-(2-Phenyl-6-(1,1,2,2-tetrafluoroethyl)pyrimidin-4-yl)phenol chemical structure, C18H12F4N2O, CAS 328285-37-6
2-(2-Phenyl-6-(1,1,2,2-tetrafluoroethyl)pyrimidin-4-yl)phenol
CAS 328285-37-6C18H12F4N2O
2-[2-Phenyl-6-(trifluoromethyl)pyrimidin-4-yl]phenol chemical structure, C17H11F3N2O, CAS 312513-50-1
2-[2-Phenyl-6-(trifluoromethyl)pyrimidin-4-yl]phenol
CAS 312513-50-1C17H11F3N2O
4-Methoxy-2-(2-phenyl-6-(trifluoromethyl)pyrimidin-4-yl)phenol chemical structure, C18H13F3N2O2, CAS 348131-46-4
4-Methoxy-2-(2-phenyl-6-(trifluoromethyl)pyrimidin-4-yl)phenol
CAS 348131-46-4C18H13F3N2O2
4-Bromo-2,6-diphenylpyrimidine chemical structure, C16H11BrN2, CAS 40734-24-5
4-Bromo-2,6-diphenylpyrimidine
CAS 40734-24-5C16H11BrN2
5-Bromo-4-hydrazino-2,6-diphenylpyrimidine chemical structure, C16H13BrN4, CAS 887571-65-5
5-Bromo-4-hydrazino-2,6-diphenylpyrimidine
CAS 887571-65-5C16H13BrN4
4-Chloro-2,6-diphenylpyrimidine-5-carbonitrile chemical structure, C17H10ClN3, CAS 737-53-1
4-Chloro-2,6-diphenylpyrimidine-5-carbonitrile
CAS 737-53-1C17H10ClN3
5-Bromo-4-chloro-2,6-diphenylpyrimidine chemical structure, C16H10BrClN2, CAS 40780-01-6
5-Bromo-4-chloro-2,6-diphenylpyrimidine
CAS 40780-01-6C16H10BrClN2
4,5-Dibromo-2,6-diphenylpyrimidine chemical structure, C16H10Br2N2, CAS 40734-25-6
4,5-Dibromo-2,6-diphenylpyrimidine
CAS 40734-25-6C16H10Br2N2
4-Methyl-2-(2-phenyl-6-(1,1,2,2-tetrafluoroethyl)pyrimidin-4-yl)phenol chemical structure, C19H14F4N2O, CAS 348131-42-0
4-Methyl-2-(2-phenyl-6-(1,1,2,2-tetrafluoroethyl)pyrimidin-4-yl)phenol
CAS 348131-42-0C19H14F4N2O
4-Nitro-2-(2-phenyl-6-(trifluoromethyl)pyrimidin-4-yl)phenol chemical structure, C17H10F3N3O3, CAS 348131-44-2
4-Nitro-2-(2-phenyl-6-(trifluoromethyl)pyrimidin-4-yl)phenol
CAS 348131-44-2C17H10F3N3O3
N-Methyl-2,4-diphenylpyrimidine-5-carboxamide chemical structure, C18H15N3O, CAS 338771-85-0
N-Methyl-2,4-diphenylpyrimidine-5-carboxamide
CAS 338771-85-0C18H15N3O
N-Ethyl-2,4-diphenyl-5-pyrimidinecarboxamide chemical structure, C19H17N3O, CAS 338771-87-2
N-Ethyl-2,4-diphenyl-5-pyrimidinecarboxamide
CAS 338771-87-2C19H17N3O
N-Isopropyl-2,4-diphenyl-5-pyrimidinecarboxamide chemical structure, C20H19N3O, CAS 338771-97-4
N-Isopropyl-2,4-diphenyl-5-pyrimidinecarboxamide
CAS 338771-97-4C20H19N3O
N,N-Dimethyl-2,4-diphenylpyrimidine-5-carboxamide chemical structure, C19H17N3O, CAS 338771-99-6
N,N-Dimethyl-2,4-diphenylpyrimidine-5-carboxamide
CAS 338771-99-6C19H17N3O
N-(2-Methylbut-3-yn-2-yl)-2,4-diphenylpyrimidine-5-carboxamide chemical structure, C22H19N3O, CAS 338772-03-5
N-(2-Methylbut-3-yn-2-yl)-2,4-diphenylpyrimidine-5-carboxamide
CAS 338772-03-5C22H19N3O
4-Chloro-6-(4-methoxyphenyl)-2-(4-methylphenyl)-5-pyrimidinecarbonitrile chemical structure, C19H14ClN3O, CAS 400081-14-3
4-Chloro-6-(4-methoxyphenyl)-2-(4-methylphenyl)-5-pyrimidinecarbonitrile
CAS 400081-14-3C19H14ClN3O