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Murcko scaffold

4,6-Diphenyl-3,4-dihydro-1H-pyrimidin-2-one scaffold

26 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
26
With full pages
9
Scaffold SMILES

O=C1NC(c2ccccc2)=CC(c2ccccc2)N1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4,6-Diphenyl-3,4-dihydro-1H-pyrimidin-2-one page
Murcko scaffold O=C1NC(c2ccccc2)=CC(c2ccccc2)N1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 26 of 26 chemicals

5-Nitro-4,6-diphenyl-3,4-dihydro-2(1H)-pyrimidinone chemical structure, C16H13N3O3, CAS 37673-85-1
5-Nitro-4,6-diphenyl-3,4-dihydro-2(1H)-pyrimidinone
CAS 37673-85-1C16H13N3O3
4,6-Diphenyl-3,4-dihydro-1H-pyrimidin-2-one chemical structure, C16H14N2O, CAS 4113-79-5
4,6-Diphenyl-3,4-dihydro-1H-pyrimidin-2-one
CAS 4113-79-5C16H14N2O
Ethyl 4-(2-chlorophenyl)-1-methyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C20H19ClN2O3, CAS 300697-64-7
Ethyl 4-(2-chlorophenyl)-1-methyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 300697-64-7C20H19ClN2O3
Ethyl 4-(2-fluorophenyl)-1-methyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C20H19FN2O3, CAS 300697-67-0
Ethyl 4-(2-fluorophenyl)-1-methyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 300697-67-0C20H19FN2O3
Ethyl 4-(3,4-dimethoxyphenyl)-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C21H22N2O5, CAS 328540-06-3
Ethyl 4-(3,4-dimethoxyphenyl)-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 328540-06-3C21H22N2O5
Ethyl 4-(2,3-dimethoxyphenyl)-2-oxo-6-phenyl-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate chemical structure, C21H22N2O5, CAS 303141-41-5
Ethyl 4-(2,3-dimethoxyphenyl)-2-oxo-6-phenyl-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
CAS 303141-41-5C21H22N2O5
Ethyl 4-(4-chlorophenyl)-6-(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate chemical structure, C20H19ClN2O4, CAS 303136-50-7
Ethyl 4-(4-chlorophenyl)-6-(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
CAS 303136-50-7C20H19ClN2O4
Ethyl 6-(4-methoxyphenyl)-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C20H19N3O6, CAS 303136-59-6
Ethyl 6-(4-methoxyphenyl)-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 303136-59-6C20H19N3O6
Ethyl 4-(4-bromophenyl)-6-(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C20H19BrN2O4, CAS 303136-98-3
Ethyl 4-(4-bromophenyl)-6-(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 303136-98-3C20H19BrN2O4
Ethyl 4-(3-bromophenyl)-6-(4-methoxyphenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate chemical structure, C20H19BrN2O4, CAS 313967-75-8
Ethyl 4-(3-bromophenyl)-6-(4-methoxyphenyl)-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
CAS 313967-75-8C20H19BrN2O4
Ethyl 4-(2,5-dimethoxyphenyl)-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C21H22N2O5, CAS 303138-14-9
Ethyl 4-(2,5-dimethoxyphenyl)-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 303138-14-9C21H22N2O5
Ethyl 4,6-bis(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C21H22N2O5, CAS 5721-00-6
Ethyl 4,6-bis(4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 5721-00-6C21H22N2O5
Ethyl 4-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C20H19BrN2O5, CAS 313245-05-5
Ethyl 4-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 313245-05-5C20H19BrN2O5
Ethyl 4-(3,5-dichloro-2-methoxyphenyl)-2-oxo-6-phenyl-3,4-dihydro-1H-pyrimidine-5-carboxylate chemical structure, C20H18Cl2N2O4, CAS 354780-99-7
Ethyl 4-(3,5-dichloro-2-methoxyphenyl)-2-oxo-6-phenyl-3,4-dihydro-1H-pyrimidine-5-carboxylate
CAS 354780-99-7C20H18Cl2N2O4
4-(3-Chlorophenyl)-3,4-dihydro-5-nitro-6-phenyl-2(1H)-pyrimidinone chemical structure, C16H12ClN3O3, CAS 560130-43-0
4-(3-Chlorophenyl)-3,4-dihydro-5-nitro-6-phenyl-2(1H)-pyrimidinone
CAS 560130-43-0C16H12ClN3O3
Ethyl 4-(4-hydroxy-3-methoxyphenyl)-1-methyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C21H22N2O5, CAS 304864-73-1
Ethyl 4-(4-hydroxy-3-methoxyphenyl)-1-methyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 304864-73-1C21H22N2O5
Ethyl 4-[4-(difluoromethoxy)-3-methoxyphenyl]-1-methyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C22H22F2N2O5, CAS 312507-38-3
Ethyl 4-[4-(difluoromethoxy)-3-methoxyphenyl]-1-methyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 312507-38-3C22H22F2N2O5
Ethyl 2-oxo-6-phenyl-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C22H24N2O6, CAS 362497-71-0
Ethyl 2-oxo-6-phenyl-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 362497-71-0C22H24N2O6
Ethyl 4-(2-bromo-5-methoxy-4-propoxyphenyl)-2-oxo-6-phenyl-3,4-dihydro-1H-pyrimidine-5-carboxylate chemical structure, C23H25BrN2O5, CAS 664977-86-0
Ethyl 4-(2-bromo-5-methoxy-4-propoxyphenyl)-2-oxo-6-phenyl-3,4-dihydro-1H-pyrimidine-5-carboxylate
CAS 664977-86-0C23H25BrN2O5
Ethyl 4-(4-(dimethylamino)phenyl)-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C21H23N3O3, CAS 331839-71-5
Ethyl 4-(4-(dimethylamino)phenyl)-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 331839-71-5C21H23N3O3
Ethyl 4-(2-methoxyphenyl)-1-methyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C21H22N2O4, CAS 400067-48-3
Ethyl 4-(2-methoxyphenyl)-1-methyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 400067-48-3C21H22N2O4
Ethyl 4-(2-fluorophenyl)-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C19H17FN2O3, CAS 313959-87-4
Ethyl 4-(2-fluorophenyl)-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 313959-87-4C19H17FN2O3
Ethyl 4-(2-hydroxy-5-nitrophenyl)-1-methyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate chemical structure, C20H19N3O6, CAS 329908-34-1
Ethyl 4-(2-hydroxy-5-nitrophenyl)-1-methyl-2-oxo-6-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS 329908-34-1C20H19N3O6
3-Methyl-6-(4-methylphenyl)-4-phenyl-3,4-dihydropyrimidin-2(1H)-one chemical structure, C18H18N2O, CAS 88129-09-3
3-Methyl-6-(4-methylphenyl)-4-phenyl-3,4-dihydropyrimidin-2(1H)-one
CAS 88129-09-3C18H18N2O