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Murcko scaffold

Ring system with 3 rings and 22 atoms

54 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
54
With full pages
18
Scaffold SMILES

O=C(CCN1C(=O)c2ccccc2C1=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CCN1C(=O)c2ccccc2C1=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 54 chemicals

3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-N-p-tolyl-propionamide chemical structure, C18H16N2O3, CAS 57500-75-1
3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-N-p-tolyl-propionamide
CAS 57500-75-1C18H16N2O3
N-(4-Dimethylamino-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionamide chemical structure, C19H19N3O3, CAS 301196-51-0
N-(4-Dimethylamino-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionamide
CAS 301196-51-0C19H19N3O3
N-(5-Chloro-2-methylphenyl)-3-(1,3-dioxoisoindol-2-yl)propanamide chemical structure, C18H15ClN2O3, CAS 303972-71-6
N-(5-Chloro-2-methylphenyl)-3-(1,3-dioxoisoindol-2-yl)propanamide
CAS 303972-71-6C18H15ClN2O3
3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(2-fluorophenyl)propanamide chemical structure, C17H13FN2O3, CAS 303972-70-5
3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(2-fluorophenyl)propanamide
CAS 303972-70-5C17H13FN2O3
3-(1,3-Dioxo-2,3-dihydro-1H-isoindol-2-yl)-N-(3-methylphenyl)propanamide chemical structure, C18H16N2O3, CAS 303122-57-8
3-(1,3-Dioxo-2,3-dihydro-1H-isoindol-2-yl)-N-(3-methylphenyl)propanamide
CAS 303122-57-8C18H16N2O3
3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-N-(4-methoxy-phenyl)-propionamide chemical structure, C18H16N2O4, CAS 57500-76-2
3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-N-(4-methoxy-phenyl)-propionamide
CAS 57500-76-2C18H16N2O4
3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-N-(4-isopropyl-phenyl)-propionamide chemical structure, C20H20N2O3, CAS 6047-57-0
3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-N-(4-isopropyl-phenyl)-propionamide
CAS 6047-57-0C20H20N2O3
3-{[3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl]amino}benzoic acid chemical structure, C18H14N2O5, CAS 361198-12-1
3-{[3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl]amino}benzoic acid
CAS 361198-12-1C18H14N2O5
N-(3-Chloro-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionamide chemical structure, C17H13ClN2O3, CAS 303794-55-0
N-(3-Chloro-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionamide
CAS 303794-55-0C17H13ClN2O3
3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(2-ethoxyphenyl)propanamide chemical structure, C19H18N2O4, CAS 361182-61-8
3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(2-ethoxyphenyl)propanamide
CAS 361182-61-8C19H18N2O4
3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(4-ethylphenyl)propanamide chemical structure, C19H18N2O3, CAS 304675-16-9
3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(4-ethylphenyl)propanamide
CAS 304675-16-9C19H18N2O3
3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(2-methoxyphenyl)propanamide chemical structure, C18H16N2O4, CAS 303122-32-9
3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-(2-methoxyphenyl)propanamide
CAS 303122-32-9C18H16N2O4
3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-N-o-tolyl-propionamide chemical structure, C18H16N2O3, CAS 303122-56-7
3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-N-o-tolyl-propionamide
CAS 303122-56-7C18H16N2O3
N-(2-Chloro-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionamide chemical structure, C17H13ClN2O3, CAS 303795-00-8
N-(2-Chloro-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionamide
CAS 303795-00-8C17H13ClN2O3
N-(3-Chloro-4-fluorophenyl)-3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanamide chemical structure, C17H12ClFN2O3, CAS 304889-96-1
N-(3-Chloro-4-fluorophenyl)-3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanamide
CAS 304889-96-1C17H12ClFN2O3
N-(4-Chlorophenyl)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanamide chemical structure, C17H13ClN2O3, CAS 307526-06-3
N-(4-Chlorophenyl)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanamide
CAS 307526-06-3C17H13ClN2O3
3-(1,3-Dioxoisoindol-2-yl)-N-(2-methoxy-5-methylphenyl)propanamide chemical structure, C19H18N2O4, CAS 449155-76-4
3-(1,3-Dioxoisoindol-2-yl)-N-(2-methoxy-5-methylphenyl)propanamide
CAS 449155-76-4C19H18N2O4
N-(4-Chloro-2-methylphenyl)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanamide chemical structure, C18H15ClN2O3, CAS 449156-29-0
N-(4-Chloro-2-methylphenyl)-3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanamide
CAS 449156-29-0C18H15ClN2O3
N-(3,4-Dimethylphenyl)-3-(1,3-dioxoisoindol-2-yl)propanamide chemical structure, C19H18N2O3, CAS 313267-27-5
N-(3,4-Dimethylphenyl)-3-(1,3-dioxoisoindol-2-yl)propanamide
CAS 313267-27-5C19H18N2O3
2-{[3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl]amino}benzoic acid chemical structure, C18H14N2O5, CAS 364627-30-5
2-{[3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl]amino}benzoic acid
CAS 364627-30-5C18H14N2O5
3-(1,3-Dioxoisoindol-2-yl)-N-(4-iodophenyl)propanamide chemical structure, C17H13IN2O3, CAS 313702-39-5
3-(1,3-Dioxoisoindol-2-yl)-N-(4-iodophenyl)propanamide
CAS 313702-39-5C17H13IN2O3
Ethyl 2-(3-(1,3-dioxoisoindolin-2-yl)propanamido)benzoate chemical structure, C20H18N2O5, CAS 305377-30-4
Ethyl 2-(3-(1,3-dioxoisoindolin-2-yl)propanamido)benzoate
CAS 305377-30-4C20H18N2O5
3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[2-(trifluoromethyl)phenyl]propanamide chemical structure, C18H13F3N2O3, CAS 256955-65-4
3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[2-(trifluoromethyl)phenyl]propanamide
CAS 256955-65-4C18H13F3N2O3
N-(4-Acetamidophenyl)-3-(1,3-dioxoisoindol-2-yl)propanamide chemical structure, C19H17N3O4, CAS 302928-77-4
N-(4-Acetamidophenyl)-3-(1,3-dioxoisoindol-2-yl)propanamide
CAS 302928-77-4C19H17N3O4