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Murcko scaffold

Ring system with 3 rings and 23 atoms

85 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
85
With full pages
19
Scaffold SMILES

O=C(CCN1C(=O)c2ccccc2S1(=O)=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CCN1C(=O)c2ccccc2S1(=O)=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 85 chemicals

3-(1,1-Dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-(2-fluorophenyl)propanamide chemical structure, C16H13FN2O4S, CAS 723741-12-6
3-(1,1-Dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-(2-fluorophenyl)propanamide
CAS 723741-12-6C16H13FN2O4S
N-(2,3-Dichlorophenyl)-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide chemical structure, C16H12Cl2N2O4S, CAS 709010-65-1
N-(2,3-Dichlorophenyl)-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide
CAS 709010-65-1C16H12Cl2N2O4S
N-(2,5-Dimethylphenyl)-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide chemical structure, C18H18N2O4S, CAS 723741-02-4
N-(2,5-Dimethylphenyl)-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide
CAS 723741-02-4C18H18N2O4S
3-(1,1-Dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-[3-(trifluoromethyl)phenyl]propanamide chemical structure, C17H13F3N2O4S, CAS 663167-99-5
3-(1,1-Dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-[3-(trifluoromethyl)phenyl]propanamide
CAS 663167-99-5C17H13F3N2O4S
N-(4-Bromo-2-methylphenyl)-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide chemical structure, C17H15BrN2O4S, CAS 663167-84-8
N-(4-Bromo-2-methylphenyl)-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide
CAS 663167-84-8C17H15BrN2O4S
3-(1,1-Dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-(2-isopropenylphenyl)propanamide chemical structure, C19H18N2O4S, CAS 666712-65-8
3-(1,1-Dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-(2-isopropenylphenyl)propanamide
CAS 666712-65-8C19H18N2O4S
N-(4-Chlorophenyl)-3-(1,1,3-trioxo-1,2-benzothiazol-2-yl)propanamide chemical structure, C16H13ClN2O4S, CAS 663169-10-6
N-(4-Chlorophenyl)-3-(1,1,3-trioxo-1,2-benzothiazol-2-yl)propanamide
CAS 663169-10-6C16H13ClN2O4S
3-(1,1-Dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)-N-(2-methyl-5-nitrophenyl)propanamide chemical structure, C17H15N3O6S, CAS 663167-70-2
3-(1,1-Dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)-N-(2-methyl-5-nitrophenyl)propanamide
CAS 663167-70-2C17H15N3O6S
N-(4-Chloro-2,5-dimethoxyphenyl)-3-(1,1,3-trioxo-1,2-benzothiazol-2-yl)propanamide chemical structure, C18H17ClN2O6S, CAS 663167-73-5
N-(4-Chloro-2,5-dimethoxyphenyl)-3-(1,1,3-trioxo-1,2-benzothiazol-2-yl)propanamide
CAS 663167-73-5C18H17ClN2O6S
N-(2,4-Difluorophenyl)-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide chemical structure, C16H12F2N2O4S, CAS 663168-53-4
N-(2,4-Difluorophenyl)-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide
CAS 663168-53-4C16H12F2N2O4S
3-(1,1-Dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-[2-(trifluoromethyl)phenyl]propanamide chemical structure, C17H13F3N2O4S, CAS 663167-76-8
3-(1,1-Dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-[2-(trifluoromethyl)phenyl]propanamide
CAS 663167-76-8C17H13F3N2O4S
N-(2-Methoxy-5-nitrophenyl)-3-(1,1,3-trioxo-1,2-benzothiazol-2-yl)propanamide chemical structure, C17H15N3O7S, CAS 663167-83-7
N-(2-Methoxy-5-nitrophenyl)-3-(1,1,3-trioxo-1,2-benzothiazol-2-yl)propanamide
CAS 663167-83-7C17H15N3O7S
N-(4-Bromo-3-methylphenyl)-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide chemical structure, C17H15BrN2O4S, CAS 663168-00-1
N-(4-Bromo-3-methylphenyl)-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide
CAS 663168-00-1C17H15BrN2O4S
N-(3-{[3-(1,1-Dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanoyl]amino}phenyl)-2-methylpropanamide chemical structure, C20H21N3O5S, CAS 663167-80-4
N-(3-{[3-(1,1-Dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanoyl]amino}phenyl)-2-methylpropanamide
CAS 663167-80-4C20H21N3O5S
Ethyl 4-(3-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)propanamido)benzoate chemical structure, C19H18N2O6S, CAS 663167-81-5
Ethyl 4-(3-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)propanamido)benzoate
CAS 663167-81-5C19H18N2O6S
N-(3-Chloro-4-methylphenyl)-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide chemical structure, C17H15ClN2O4S, CAS 663167-68-8
N-(3-Chloro-4-methylphenyl)-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide
CAS 663167-68-8C17H15ClN2O4S
3-(1,1-Dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-(2-methoxyphenyl)propanamide chemical structure, C17H16N2O5S, CAS 663168-41-0
3-(1,1-Dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-(2-methoxyphenyl)propanamide
CAS 663168-41-0C17H16N2O5S
N-(3-Acetylphenyl)-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide chemical structure, C18H16N2O5S, CAS 663167-69-9
N-(3-Acetylphenyl)-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide
CAS 663167-69-9C18H16N2O5S
N-(5-Chloro-2-methoxyphenyl)-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide chemical structure, C17H15ClN2O5S, CAS 663167-86-0
N-(5-Chloro-2-methoxyphenyl)-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide
CAS 663167-86-0C17H15ClN2O5S
N-(3-Chloro-2-methylphenyl)-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide chemical structure, C17H15ClN2O4S, CAS 663167-88-2
N-(3-Chloro-2-methylphenyl)-3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propanamide
CAS 663167-88-2C17H15ClN2O4S
3-(1,1-Dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-(4-isopropylphenyl)propanamide chemical structure, C19H20N2O4S, CAS 663167-89-3
3-(1,1-Dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-(4-isopropylphenyl)propanamide
CAS 663167-89-3C19H20N2O4S
3-(1,1-Dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-(3-methoxyphenyl)propanamide chemical structure, C17H16N2O5S, CAS 663167-91-7
3-(1,1-Dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-(3-methoxyphenyl)propanamide
CAS 663167-91-7C17H16N2O5S
3-(1,1-Dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)-N-(3-nitrophenyl)propanamide chemical structure, C16H13N3O6S, CAS 663167-93-9
3-(1,1-Dioxido-3-oxo-1,2-benzothiazol-2(3H)-yl)-N-(3-nitrophenyl)propanamide
CAS 663167-93-9C16H13N3O6S
3-(1,1-Dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-(4-methoxyphenyl)propanamide chemical structure, C17H16N2O5S, CAS 663168-20-5
3-(1,1-Dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)-N-(4-methoxyphenyl)propanamide
CAS 663168-20-5C17H16N2O5S