Murcko scaffold
Ring system with 3 rings and 20 atoms
187 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 20
- Chemicals
- 187
- With full pages
- 20
Scaffold SMILES
O=C(COc1ccccc1)Nc1cc2c(s1)CCCC2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 187 chemicals
![Methyl 2-[(phenoxyacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C18H19NO4S, CAS 324073-88-3](/s/LKEASMKHQLQHBI-UHFFFAOYSA-N.svg)
Methyl 2-[(phenoxyacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 324073-88-3C18H19NO4S
![2-[(Phenoxyacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C17H18N2O3S, CAS 301224-25-9](/s/QMANVEHUKUATCF-UHFFFAOYSA-N.svg)
2-[(Phenoxyacetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 301224-25-9C17H18N2O3S
![2-{[(3-Methylphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C18H20N2O3S, CAS 315675-80-0](/s/KXPFOFQSHZMWCO-UHFFFAOYSA-N.svg)
2-{[(3-Methylphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 315675-80-0C18H20N2O3S
2-(((2-Methylphenoxy)AC)amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 303092-53-7C18H20N2O3S
![2-{[(4-Methylphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C18H20N2O3S, CAS 315675-97-9](/s/PFNBESUTGZGSKJ-UHFFFAOYSA-N.svg)
2-{[(4-Methylphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 315675-97-9C18H20N2O3S
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-(2,3-dimethylphenoxy)acetamide
CAS 329225-11-8C19H20N2O2S
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-(2-methylphenoxy)acetamide
CAS 303092-51-5C18H18N2O2S
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-phenoxyacetamide
CAS 301355-04-4C17H16N2O2S
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-(3-methylphenoxy)acetamide
CAS 349474-21-1C18H18N2O2S
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-(2-methoxyphenoxy)acetamide
CAS 373611-52-0C18H18N2O3S
![Methyl 2-{[(2,4-dichlorophenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C18H17Cl2NO4S, CAS 312704-26-0](/s/ADCPRELOHXPRLZ-UHFFFAOYSA-N.svg)
Methyl 2-{[(2,4-dichlorophenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 312704-26-0C18H17Cl2NO4S
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-(2,4-dichlorophenoxy)acetamide
CAS 300377-13-3C17H14Cl2N2O2S
![2-{[(4-Chlorophenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C17H17ClN2O3S, CAS 301224-27-1](/s/GKXYBIXXKBGULS-UHFFFAOYSA-N.svg)
2-{[(4-Chlorophenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 301224-27-1C17H17ClN2O3S
![Methyl 2-{[(4-chlorophenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C18H18ClNO4S, CAS 324072-77-7](/s/HDXLHHLVALHNOU-UHFFFAOYSA-N.svg)
Methyl 2-{[(4-chlorophenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 324072-77-7C18H18ClNO4S
Ethyl 2-(2-phenoxyacetamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 300828-25-5C19H21NO4S
![2-{[(2-Chlorophenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C17H17ClN2O3S, CAS 301678-81-9](/s/RKSHZMFKFKYCOX-UHFFFAOYSA-N.svg)
2-{[(2-Chlorophenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 301678-81-9C17H17ClN2O3S
![Ethyl 2-{[2-(4-fluorophenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C19H20FNO4S, CAS 299417-45-1](/s/KOSPQXSJSKYHPR-UHFFFAOYSA-N.svg)
Ethyl 2-{[2-(4-fluorophenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 299417-45-1C19H20FNO4S
![2-{[(2-Methoxyphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C18H20N2O4S, CAS 302550-15-8](/s/VPMDQOULYWSNGQ-UHFFFAOYSA-N.svg)
2-{[(2-Methoxyphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 302550-15-8C18H20N2O4S
N-Ethyl-2-(((2-methylphenoxy)acetyl)amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 303092-54-8C20H24N2O3S
ME 2-(((2-ME-Phenoxy)AC)amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 301694-25-7C19H21NO4S
ET 2-(((2-ME-Phenoxy)AC)amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 299950-97-3C20H23NO4S
![Methyl 2-{[(2,6-dimethylphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C20H23NO4S, CAS 307505-52-8](/s/RBNNEZMLKWYUMH-UHFFFAOYSA-N.svg)
Methyl 2-{[(2,6-dimethylphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 307505-52-8C20H23NO4S
![2-{[(4-Chloro-2-methylphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C18H19ClN2O3S, CAS 349477-15-2](/s/GQXBHEIRAPJWNN-UHFFFAOYSA-N.svg)
2-{[(4-Chloro-2-methylphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS 349477-15-2C18H19ClN2O3S
![Methyl 2-{[(2-bromo-4-methylphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate chemical structure, C19H20BrNO4S, CAS 431977-18-3](/s/FFAMERWEHBHALE-UHFFFAOYSA-N.svg)
Methyl 2-{[(2-bromo-4-methylphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate
CAS 431977-18-3C19H20BrNO4S
- 2-{[(2-Bromo-4-ethylphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide590400-45-6C19H21BrN2O3S
- Methyl 2-{[(4-bromo-2-chlorophenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate511250-79-6C18H17BrClNO4S
- 2-{[(2-Bromo-4-chlorophenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide403714-36-3C17H16BrClN2O3S
- Methyl 2-{[(2-isopropylphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate606923-47-1C21H25NO4S
- 2-{[(2-Isopropylphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide650620-44-3C20H24N2O3S
- 2-[[2-(2-Bromophenoxy)acetyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide307537-43-5C17H17BrN2O3S
- N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2-(4-propan-2-ylphenoxy)acetamide329225-08-3C20H22N2O2S
- Methyl 2-{[(2-bromo-4-chlorophenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate447449-29-8C18H17BrClNO4S
- Ethyl 2-{[(2-methoxyphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate352342-78-0C20H23NO5S
- Methyl 2-{[(2,5-dimethylphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate315713-25-8C20H23NO4S
- Ethyl 2-{[(2,5-dichlorophenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate301305-00-0C19H19Cl2NO4S
- Methyl 2-{[(4-methoxyphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate300559-60-8C19H21NO5S
- Methyl 2-{[(3-methylphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate347364-92-5C19H21NO4S
- Ethyl 2-{[(3-bromophenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate302805-59-0C19H20BrNO4S
- N-ET-2-((Phenoxyacetyl)amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide503864-99-1C19H22N2O3S
- N-Ethyl-2-{[(2-methoxyphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide493002-55-4C20H24N2O4S
- 2-[2-(4-Methoxyphenoxy)acetamido]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide301224-31-7C18H20N2O4S
- Ethyl 2-[2-(2,4-dichlorophenoxy)acetamido]-4,5,6,7-tetrahydrobenzo[B]thiophene-3-carboxylate67836-06-0C19H19Cl2NO4S
- Methyl 2-(2-(3-methoxyphenoxy)acetamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate333766-44-2C19H21NO5S
- Ethyl 2-[2-(4-bromophenoxy)acetamido]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate300828-30-2C19H20BrNO4S
- 2-[[2-(4-Bromo-3-methylphenoxy)acetyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide302553-28-2C18H19BrN2O3S
- Methyl 2-[[2-(2-methoxyphenoxy)acetyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate335421-01-7C19H21NO5S
- N-Ethyl-2-{[(4-methylphenoxy)acetyl]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide440088-18-6C20H24N2O3S
- N-Ethyl-2-[2-(4-fluorophenoxy)acetamido]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide440088-17-5C19H21FN2O3S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=C(CSc1nc2ccccc2[nH]1)Nc1ccccc1](/scaffold/WVWIDWYWASPVGN-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nc2ccccc2[nH]1)Nc1ccccc149 chemicals![Scaffold c1ccc(OCCSc2nc3ccccc3[nH]2)cc1](/scaffold/UEYUFQWEHMSHIX-UHFFFAOYSA-N/structure.svg)
c1ccc(OCCSc2nc3ccccc3[nH]2)cc136 chemicals![Scaffold O=C(NCCc1nc2ccccc2[nH]1)c1ccccc1](/scaffold/YRGGTYXDASSWSH-UHFFFAOYSA-N/structure.svg)
O=C(NCCc1nc2ccccc2[nH]1)c1ccccc124 chemicals
O=C(COc1ccccc1)Nc1nc2ccccc2s122 chemicals
O=C(CCN1C(=O)c2ccccc2S1(=O)=O)Nc1ccccc119 chemicals
O=C(CCN1C(=O)c2ccccc2C1=O)Nc1ccccc118 chemicals
O=C(CS(=O)(=O)c1ccccc1)Nc1nc2ccccc2s117 chemicals
O=C(CSc1nc2ccccc2s1)Nc1ccccc114 chemicals![Scaffold O=C(NN=Cc1ccccc1)c1cc2ccccc2[nH]1](/scaffold/SYUQFFCOGGAGKC-UHFFFAOYSA-N/structure.svg)
O=C(NN=Cc1ccccc1)c1cc2ccccc2[nH]113 chemicals
O=C(CN1C(=O)c2ccccc2C1=O)NCc1ccccc111 chemicals
O=C(CN1C(=O)c2ccccc2S1(=O)=O)NCc1ccccc111 chemicals
O=C(CCc1ccccc1)Nc1nc2ccccc2s111 chemicals