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Murcko scaffold

Ring system with 3 rings and 19 atoms

32 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
19
Chemicals
32
With full pages
5
Scaffold SMILES

O=C(C=Cc1c[nH]c2ccccc12)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(C=Cc1c[nH]c2ccccc12)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 32 of 32 chemicals

2-Propen-1-one, 3-(1H-indol-3-yl)-1-(3-nitrophenyl)-, (E)- chemical structure, C17H12N2O3, CAS 151390-86-2
2-Propen-1-one, 3-(1H-indol-3-yl)-1-(3-nitrophenyl)-, (E)-
CAS 151390-86-2C17H12N2O3
2-Propen-1-one, 1-(4-methoxyphenyl)-3-(1-methyl-1H-indol-3-yl)- chemical structure, C19H17NO2, CAS 27664-11-5
2-Propen-1-one, 1-(4-methoxyphenyl)-3-(1-methyl-1H-indol-3-yl)-
CAS 27664-11-5C19H17NO2
2-(4-Chlorobenzoyl)-3-(5-methoxy-1H-indol-3-yl)acrylonitrile chemical structure, C19H13ClN2O2
2-(4-Chlorobenzoyl)-3-(5-methoxy-1H-indol-3-yl)acrylonitrile
C19H13ClN2O2
Tyrphostin AG 808 chemical structure, C18H12N2O3, CAS 160953-95-7
Tyrphostin AG 808
CAS 160953-95-7C18H12N2O3
(E)-2-Benzoyl-3-(1H-indol-3-yl)prop-2-enenitrile chemical structure, C18H12N2O, CAS 34023-76-2
(E)-2-Benzoyl-3-(1H-indol-3-yl)prop-2-enenitrile
CAS 34023-76-2C18H12N2O
(E)-3-(1H-Indol-3-yl)-1-(4-nitrophenyl)prop-2-en-1-one chemical structure, C17H12N2O3, CAS 22883-33-6
(E)-3-(1H-Indol-3-yl)-1-(4-nitrophenyl)prop-2-en-1-one
CAS 22883-33-6C17H12N2O3
3-(1H-Indol-3-yl)-1-(4-methylphenyl)-2-propen-1-one chemical structure, C18H15NO, CAS 38470-67-6
3-(1H-Indol-3-yl)-1-(4-methylphenyl)-2-propen-1-one
CAS 38470-67-6C18H15NO
(E)-1-(4-Chlorophenyl)-3-(1-methyl-1H-indol-3-yl)prop-2-en-1-one chemical structure, C18H14ClNO, CAS 73393-86-9
(E)-1-(4-Chlorophenyl)-3-(1-methyl-1H-indol-3-yl)prop-2-en-1-one
CAS 73393-86-9C18H14ClNO
(E)-1-(4-Chlorophenyl)-3-(1H-indol-3-yl)prop-2-en-1-one chemical structure, C17H12ClNO, CAS 38470-72-3
(E)-1-(4-Chlorophenyl)-3-(1H-indol-3-yl)prop-2-en-1-one
CAS 38470-72-3C17H12ClNO
(E)-1-(4-Methoxyphenyl)-3-(1-methylindol-3-yl)prop-2-en-1-one chemical structure, C19H17NO2, CAS 1237055-56-9
(E)-1-(4-Methoxyphenyl)-3-(1-methylindol-3-yl)prop-2-en-1-one
CAS 1237055-56-9C19H17NO2
(E)-3-(1-Methyl-1H-indol-3-yl)-1-(p-tolyl)prop-2-en-1-one chemical structure, C19H17NO, CAS 1644490-68-5
(E)-3-(1-Methyl-1H-indol-3-yl)-1-(p-tolyl)prop-2-en-1-one
CAS 1644490-68-5C19H17NO
(2E)-3-(1H-Indol-3-yl)-1-phenylprop-2-en-1-one chemical structure, C17H13NO, CAS 38470-63-2
(2E)-3-(1H-Indol-3-yl)-1-phenylprop-2-en-1-one
CAS 38470-63-2C17H13NO
(2E)-2-[(E)-Benzoyl]-3-(1-methyl-1H-indol-3-yl)prop-2-enenitrile chemical structure, C19H14N2O, CAS 638145-14-9
(2E)-2-[(E)-Benzoyl]-3-(1-methyl-1H-indol-3-yl)prop-2-enenitrile
CAS 638145-14-9C19H14N2O
(E)-1-(4-Fluorophenyl)-3-(1-methyl-1H-indol-3-yl)prop-2-en-1-one chemical structure, C18H14FNO, CAS 1237055-52-5
(E)-1-(4-Fluorophenyl)-3-(1-methyl-1H-indol-3-yl)prop-2-en-1-one
CAS 1237055-52-5C18H14FNO
(2E)-1-(4-Bromophenyl)-3-(1-methyl-1H-indol-3-yl)prop-2-en-1-one chemical structure, C18H14BrNO, CAS 372975-80-9
(2E)-1-(4-Bromophenyl)-3-(1-methyl-1H-indol-3-yl)prop-2-en-1-one
CAS 372975-80-9C18H14BrNO
(2E)-3-(1-Methyl-1H-indol-3-yl)-1-phenylprop-2-en-1-one chemical structure, C18H15NO, CAS 38470-65-4
(2E)-3-(1-Methyl-1H-indol-3-yl)-1-phenylprop-2-en-1-one
CAS 38470-65-4C18H15NO
(E)-1-(4-Bromophenyl)-3-(5-methoxy-1H-indol-3-yl)prop-2-en-1-one chemical structure, C18H14BrNO2, CAS 946149-90-2
(E)-1-(4-Bromophenyl)-3-(5-methoxy-1H-indol-3-yl)prop-2-en-1-one
CAS 946149-90-2C18H14BrNO2
(E)-3-(5-Methoxy-1H-indol-3-yl)-1-phenylprop-2-en-1-one chemical structure, C18H15NO2, CAS 946149-87-7
(E)-3-(5-Methoxy-1H-indol-3-yl)-1-phenylprop-2-en-1-one
CAS 946149-87-7C18H15NO2
(E)-2-Benzoyl-3-(5-methoxy-1H-indol-3-yl)prop-2-enenitrile chemical structure, C19H14N2O2
(E)-2-Benzoyl-3-(5-methoxy-1H-indol-3-yl)prop-2-enenitrile
C19H14N2O2
(E)-2-(4-Chlorobenzoyl)-3-(5-methoxy-1H-indol-3-yl)prop-2-enenitrile chemical structure, C19H13ClN2O2
(E)-2-(4-Chlorobenzoyl)-3-(5-methoxy-1H-indol-3-yl)prop-2-enenitrile
C19H13ClN2O2
(Z)-2-(4-Chlorobenzoyl)-3-(5-methoxy-1H-indol-3-yl)prop-2-enenitrile chemical structure, C19H13ClN2O2, CAS 861207-67-2
(Z)-2-(4-Chlorobenzoyl)-3-(5-methoxy-1H-indol-3-yl)prop-2-enenitrile
CAS 861207-67-2C19H13ClN2O2
(Z)-2-Benzoyl-3-(5-methoxy-1H-indol-3-yl)prop-2-enenitrile chemical structure, C19H14N2O2, CAS 861207-85-4
(Z)-2-Benzoyl-3-(5-methoxy-1H-indol-3-yl)prop-2-enenitrile
CAS 861207-85-4C19H14N2O2
PknB-IN-1 chemical structure, C25H30N2O2, CAS 1447917-39-6
PknB-IN-1
CAS 1447917-39-6C25H30N2O2
3-(5-Bromo-1H-indol-3-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one chemical structure, C20H18BrNO4, CAS 2102881-54-7
3-(5-Bromo-1H-indol-3-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
CAS 2102881-54-7C20H18BrNO4